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Eric Lespessailles

Publications and source records attributed to Eric Lespessailles.

7 recordsLinked to original sources
PubMed2006

Imaging techniques for evaluating bone microarchitecture.

At present, fracture risk prediction in the individual patient relies chiefly on bone mineral density (BMD) measurements. However, many lines of evidence indicate that the decreased bone strength characteristic of osteoporosis is dependent not only on BMD, but also on other factors, most notably bone microarchitecture. Here, we review available tools for characterizing trabecular microarchitecture (in terms of morphology, topology, and texture) and for obtaining 2D and 3D images (using radiography, computed tomography, and magnetic resonance imaging). Bone microarchitecture imaging is a noninvasive method that may improve fracture risk prediction in the individual patient, shed light on the pathophysiology of osteoporosis, and help to monitor the effects of treatments. Among the various methods available to date, magnetic resonance imaging has the advantage of involving no radiation exposure, although its limited availability restricts its usefulness for studying vast populations. Regardless of the methods selected to assess bone microarchitecture, there is a need for validated standardized parameters capable of improving fracture risk prediction in longitudinal studies.

Bone Density↗
PubMed2006

[Follow-up of osteoporosis treatment].

There is no linear relation between changes in bone mineral density (BMD) and reduction in fracture risk with antiresorptive agents. Interpretation of BMD changes at the individual level requires calculating the smallest significant change at each measurement center. BMD measurement is essential before administration of antiresorptive or anabolic agents for prevention or treatment of postmenopausal osteoporosis. Biochemical markers of bone turnover can be monitored after 6 months of treatment. Their interpretation requires careful assessment of their intraindividual variability.

Aged↗
PubMed2002

Osteoid osteoma multifocally located and recurrent in the carpus.

The authors report a case of osteoid osteoma located simultaneously at the right carpitate and at the proximal part of the right third metacarpian. A 31-year-old man presented in 1997 an osteoid osteoma involving the right capitate. One year after the surgical excision of the tumor, a second osteoid osteoma reappears to the same place requiring a 2nd intervention. A 3rd osteoid osteoma was discovered 16 months later at the proximal part of the right third metacarpian. After every excision, the pathological aspect was compatible with a nidus of osteoid osteoma. Osteoid osteoma of capitate are very rare. Multifocal forms are exceptional. If relapses of the tumor are sometimes explained by the incomplete excision of the nidus, the pathogenesis of the true recurrence remains unclear.

Adult↗