Biomedical subjects

Eric Lis

Publications and source records attributed to Eric Lis.

21 records · Page 2Linked to original sources

PubMed2002

A phase II trial of bryostatin-1 in patients with metastatic or recurrent squamous cell carcinoma of the head and neck.

Bryostatin-1 is a macrocyclic lactone that has been shown to modulate Protein Kinase C activity and has demonstrated antitumor activity in vitro and in vivo. Fifteen patients with metastatic or recurrent squamous cell carcinoma of the head and neck were treated with bryostatin-1 at a dose of 25 mcg/m2 by continuous intravenous infusion over 24 hours once weekly for three weeks followed by a break week to complete a four-week cycle. There were no major objective responses in the 14 evaluable patients. One patient with nasopharynx cancer had disease stabilization for 4 months prior to being removed from the study due to medical issues. This clinical benefit corresponded to a radiographic decrease in metabolic activity on positron emission tomograpy (PET) scan as well as molecular evidence of tumor apoptosis in a poly[ADP-ribose] polymerase (PARP) cleavage assay. Bryostatin-1 is not recommended for use as a single agent for the treatment of squamous cell head and neck cancer. Further investigation is warranted to determine the strength of the correlation between bryostatin-1 activity and PARP cleavage as a surrogate molecular marker of apoptosis.

Adult↗

PubMed2002

Radiation myelitis in a 5-year-old girl.

Myelopathy is an uncommon complication of radiotherapy, particularly in the pediatric age group. A 5-year-old girl with acute lymphoblastic leukemia developed a severe but transient radiculopathy after intrathecal administration of methotrexate and cytarabine for an isolated central nervous system relapse. Chemotherapy was then given through an intraventricular catheter. Owing to a second central nervous system recurrence, she was treated with craniospinal radiation. The whole brain down to the level of C2 received a dose of 2400 cGy. Two months after completion of radiation, the child developed a progressive tetraparesis, and magnetic resonance imaging revealed an enhancing lesion involving the medulla and upper cervical cord. A biopsy was consistent with a treatment-related necrotizing leukoencephalopathy. This case suggests that patients who develop neurologic dysfunction when treated with methotrexate can also be particularly susceptible to radiation-related injury.

Child, Preschool↗

PubMed2002

Review and interpretation of MR imaging studies with PACS: creating uniform series descriptors for radiologists and referring physicians.

OBJECTIVE: We sought to identify a limited set of standardized descriptors for various MR image series on a picture archiving and communications system (PACS) and to apply these descriptors to both existing and newly acquired MR images. CONCLUSION: Of the 47,028 MR image series in our PACS, approximately 2500 had been assigned unique descriptors, and nearly 82% of the descriptors had a frequency of appearance of less than 5%. We reduced the number of descriptors to 146 without loss of essential information. Use of standardized descriptors may facilitate identification of various MR image series.

Humans↗