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Erik Nelson

Publications and source records attributed to Erik Nelson.

7 recordsLinked to original sources

Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels.

Negative environmental consequences of fossil fuels and concerns about petroleum supplies have spurred the search for renewable transportation biofuels. To be a viable alternative, a biofuel should provide a net energy gain, have environmental benefits, be economically competitive, and be producible in large quantities without reducing food supplies. We use these criteria to evaluate, through life-cycle accounting, ethanol from corn grain and biodiesel from soybeans. Ethanol yields 25% more energy than the energy invested in its production, whereas biodiesel yields 93% more. Compared with ethanol, biodiesel releases just 1.0%, 8.3%, and 13% of the agricultural nitrogen, phosphorus, and pesticide pollutants, respectively, per net energy gain. Relative to the fossil fuels they displace, greenhouse gas emissions are reduced 12% by the production and combustion of ethanol and 41% by biodiesel. Biodiesel also releases less air pollutants per net energy gain than ethanol. These advantages of biodiesel over ethanol come from lower agricultural inputs and more efficient conversion of feedstocks to fuel. Neither biofuel can replace much petroleum without impacting food supplies. Even dedicating all U.S. corn and soybean production to biofuels would meet only 12% of gasoline demand and 6% of diesel demand. Until recent increases in petroleum prices, high production costs made biofuels unprofitable without subsidies. Biodiesel provides sufficient environmental advantages to merit subsidy. Transportation biofuels such as synfuel hydrocarbons or cellulosic ethanol, if produced from low-input biomass grown on agriculturally marginal land or from waste biomass, could provide much greater supplies and environmental benefits than food-based biofuels.

Agriculture↗

MR imaging of rectus femoris origin injuries.

OBJECTIVE: To describe the MR imaging findings of acute and chronic rectus femoris origin (RFO) injuries. MATERIALS AND METHODS: A retrospective review of pelvic and hip MR imaging procedures was performed over a 4-year period for detection of cases with injuries to the RFO. Subjects were classified as having either acute or chronic symptoms. MR imaging studies, radiographs, CT scans, radiology reports, medical records, and operative notes were reviewed. Imaging analysis was directed to assess injuries affecting the direct and indirect heads of the RFO. Concurrent osseous, cartilaginous and musculotendinous injuries were tabulated. RESULTS: The incidence of RFO injuries on MR imaging was 0.5% (17/3160). With the exception of one case of anterior inferior iliac spine apophysis avulsion and partial tear of the direct head of RFO, all subjects had indirect head of RFO injuries (acute injury 8/9, chronic injury 8/8). Partial tear of the direct head of RFO was less frequently seen (acute injury 3/9, chronic injury 2/8). Partial tears of the conjoint tendon were least frequent (acute 1/9, chronic 2/8). No full-thickness tears of the RFO were noted. Associated labral tears were seen in only one case, with no other concomitant abnormality of the articular cartilage or surrounding soft tissues. All RFO injuries were treated non-operatively. CONCLUSION: Injuries of the RFO are uncommon on MR examinations of pelvis/hips and may occur in a sequence progressing from indirect head injury to involvement of direct head and conjoint tendon in more severe cases.

Acute Disease↗

A double-blind randomized pilot study comparing quetiapine and divalproex for adolescent mania.

OBJECTIVE: To determine the comparative efficacy of quetiapine and divalproex for the treatment of adolescent mania. METHOD: Fifty adolescents (ages 12-18 years) with bipolar I disorder, manic or mixed episode, were randomized to quetiapine (400-600 mg/day) or divalproex (serum level 80-120 microg/mL) for 28 days for this double-blind study, which was conducted from July 2002 through January 2004. The primary efficacy measure was change in Young Mania Rating Scale (YMRS) score across the study period. RESULTS: Repeated measures analysis of variance using the last-observation carried forward data indicated no statistically significant group difference in YMRS scores across the 28 days of the study (p = 0.3). Mixed regression analyses (comparison of slopes) revealed that improvement in YMRS scores occurred more rapidly in the quetiapine than in the divalproex group for both the last-observation carried forward (p = 0.01) and observed data (p = 0.03). Response and remission rates were significantly greater in the quetiapine than in the divalproex group (p < .03). Rates of adverse events did not differ significantly between groups. CONCLUSIONS: The results suggest that quetiapine is at least as effective as divalproex in the treatment of acute manic symptoms associated with adolescent bipolar disorder; however, a quicker reduction of manic symptoms may occur with quetiapine as compared with divalproex. Quetiapine may be useful as monotherapy for the treatment of adolescents with manic or mixed episodes, although placebo-controlled studies are necessary.

Adolescent↗

Observer performance in assessing anemia on thoracic CT.

OBJECTIVE: The purpose of this study was to evaluate the ability of expert reviewers to differentiate an anemic from a nonanemic state on the basis of visual assessment of the relative attenuation of blood in the left ventricle on noncontrast thoracic CT images and to compare reviewer performance with quantitative measurement of CT density in Hounsfield units. MATERIALS AND METHODS: One hundred two noncontrast thoracic CT examinations were qualitatively reviewed by three independent reviewers. Hounsfield unit measurements of the blood in the left ventricle were recorded by a fourth individual. Anemia was defined as a hemoglobin level of less than 10 g/dL. Receiver operating characteristic (ROC) analyses of expert reviewers were compared with measured Hounsfield units. RESULTS: Hounsfield unit measurements performed significantly better than subjective reviewer analyses for differentiation of an anemic from a nonanemic state (area under ROC curve = 0.85 vs 0.72, 0.70, and 0.69; 95% confidence interval, 0.78-0.92 vs 0.63-0.81, 0.61-0.79, and 0.60-0.78, respectively; p < 0.05). With use of a CT density threshold of 35 H, the sensitivity for anemia was 76% and specificity was 81%, whereas the sensitivity of three reviewers was 40-72% with a specificity of 60-83%. Interobserver agreement was found to be poor by kappa statistic (0.0906-0.2128). The correlation coefficient for the analysis of Hounsfield unit versus hemoglobin level was 0.72. Separating data by patient sex revealed a correlation coefficient of 0.81 for men versus 0.52 for women, although the actual regression lines were not statistically different (p > 0.05). CONCLUSION: Despite expert reviewer analyses, subjective evaluations of blood attenuation characteristics are prone to inaccuracy and show poor interobserver agreement. Quantitative measurements of CT density in Hounsfield units should be performed to accurately differentiate an anemic from a nonanemic state when serum hemoglobin levels are not readily available.

Adult↗

Technical note: postgadolinium two-dimensional time-of-flight MR angiography of the foot.

OBJECTIVE: The purpose of this study was to determine the ability of postgadolinium time-of-flight (TOF) MR angiography to image the foot of patients compared to conventional TOF MR angiography. SUBJECTS AND METHODS: Six feet in five patients were included in this prospective study. Standard two-dimensional axial TOF sequences of the lower extremities, followed by three-dimensional (3D) contrast-enhanced moving-table images of the aorta to the foot during the intravenous bolus administration of gadolinium, were obtained in all patients. Two-dimensional axial respiratory-compensated TOF sequences were then obtained over the foot. Axial images and maximum intensity projections (MIP) reconstructions were evaluated by two blinded radiologists and images rated with respect to overall image quality, large-vessel and small-vessel visualization, degree of venous overlap, and extent of vessel stenosis. RESULTS: The 2D postgadolinium TOF technique resulted in an improvement in all areas of image quality compared with the noncontrast acquisition method, with very good interobserver agreement (kappa 0.67). Postcontrast images provided superior vessel visualization ( p=0.024, Wilcoxon signed rank test), with minimal artifact (84% with none, kappa 1.0), and excellent agreement on grading of dorsalis pedis stenosis (kappa 0.78). Vessel-to-background signal intensity ratio was doubled compared to the standard technique (mean 19.5, SD 6.5 versus 8.8, SD 4.5; p=0.016). CONCLUSION: Postgadolinium TOF MR angiography of the foot demonstrates significantly improved image quality over noncontrast techniques.

Aged↗

Induction of granulocytic differentiation by 2 pathways.

The CCAAT enhancer binding protein alpha (C/EBP alpha) transcription factor plays a critical role in granulocytopoiesis. Mice with a disruption of the C/EBP alpha gene demonstrate an early block in granulocytic differentiation, and disruption of C/EBP alpha function is a common theme in many types of human acute myelogenous leukemia, which is characterized by a block in myeloid development. To characterize further the nature of this block, we derived cell lines from the fetal liver of C/EBP alpha-deficient animals. These lines resembled morphologically the immature myeloid blasts observed in C/EBP alpha(-/-) fetal livers and did not express messenger RNA encoding early myeloid genes such as myeloperoxidase. Similarly, granulocytic markers such as Mac-1 and Gr-1 were not expressed; nor were erythroid and lymphoid surface antigens. Introduction of an inducible C/EBP alpha gene into the line revealed that conditional expression of C/EBP alpha induced the C/EBP family members C/EBP beta and C/EBP epsilon and subsequent granulocyte differentiation. Similar results were obtained when C/EBP alpha(-/-) cells were stimulated with the cytokines interleukin-3 and granulocyte-macrophage colony-stimulating factor, but not with all-trans retinoic acid, supporting a model of at least 2 pathways leading to the differentiation of myeloid progenitors to granulocytes and implicating induction of other C/EBP family members in granulopoiesis.

Animals↗