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Biomedical subjects

Esther Berrio

Publications and source records attributed to Esther Berrio.

5 recordsLinked to original sources
PubMed2004

Degree of polarization as an objective method of estimating scattering.

A new method of determining objectively the amount of scattered light in an optical system has been developed. It is based on measuring the degree of polarization of the light in images formed after a double pass through the system. A dual apparatus composed of a modified double-pass imaging polarimeter and a wave-front sensor was used to measure polarization properties and aberrations of the system under test. We studied the accuracy of the procedure in a system that included a lanthanum-modified lead zirconate titanate (PLZT) ceramic plate able to generate variable amounts of scattered light as a function of the applied voltage. Changes in the voltage applied to the ceramics plate modified significantly the scattering contribution while hardly altering the wave-front aberration. The degree of polarization was well correlated with the level of scattering in the system as determined by direct-intensity measurements at the tails of the double-pass images. This indicates that this polarimetric parameter provides accurate relative estimates of the amount of scattering generated in a system. The technique can be used in a number of applications, for example, to determine objectively the amount of scattered light in the human eye.

Journal Article↗
PubMed2003

Aberro-polariscope for the human eye.

We have developed an aberro-polariscope that simultaneously measures spatially resolved polarization properties and wave-front aberration in a living human eye. The setup consists of an infrared Hartmann-Shack sensor that incorporates a polariscope. A series of four Hartmann-Shack images corresponding to independent polarization states were recorded. The corresponding wave-front aberration was computed from each image. Moreover, from each set of four images spatially resolved (over the pupil plane) parameters of polarization were also determined. This instrument allows useful information on both the optical and the biomechanical properties of the eye to be obtained.

Adult↗
PubMed2002

Contribution of the cornea and internal surfaces to the change of ocular aberrations with age.

We studied the age dependence of the relative contributions of the aberrations of the cornea and the internal ocular surfaces to the total aberrations of the eye. We measured the wave-front aberration of the eye with a Hartmann-Shack sensor and the aberrations of the anterior corneal surface from the elevation data provided by a corneal topography system. The aberrations of the internal surfaces were obtained by direct subtraction of the ocular and corneal wave-front data. Measurements were obtained for normal healthy subjects with ages ranging from 20 to 70 years. The magnitude of the RMS wave-front aberration (excluding defocus and astigmatism) of the eye increases more than threefold within the age range considered. However, the aberrations of the anterior corneal surface increase only slightly with age. In most of the younger subjects, total ocular aberrations are lower than corneal aberrations, while in the older subjects the reverse condition occurs. Astigmatism, coma, and spherical aberration of the cornea are larger than in the complete eye in younger subjects, whereas the contrary is true for the older subjects. The internal ocular surfaces compensate, at least in part, for the aberrations associated with the cornea in most younger subjects, but this compensation is not present in the older subjects. These results suggest that the degradation of the ocular optics with age can be explained largely by the loss of the balance between the aberrations of the corneal and the internal surfaces.

Adult↗
PubMedDate not supplied

Corneal polarimetry after LASIK refractive surgery.

Imaging polarimetry provides spatially resolved information on the polarization properties of a system. In the case of the living human eye, polarization could be related to the corneal biomechanical properties, which vary from the normal state as a result of surgery or pathologies. We have used an aberro-polariscope, which we recently developed, to determine and to compare the spatially resolved maps of polarization parameters across the pupil between normal healthy and post-LASIK eyes. The depolarization distribution is not uniform across the pupil, with post-surgery eyes presenting larger levels of depolarization. While retardation increases along the radius in normal eyes, this pattern becomes irregular after LASIK refractive surgery. The maps of slow axis also differ in normal and post-surgery eyes, with a larger disorder in post-LASIK eyes. Since these changes in polarization indicate subtle structural modifications of the cornea, this approach can be useful in a clinical environment to follow the biomechanical and optical changes of the cornea after refractive surgery or for the early diagnosis of different corneal pathologies.

Adult↗