Biomedical subjects

Esther C J Consten

Publications and source records attributed to Esther C J Consten.

5 recordsLinked to original sources

PubMed2006

Minimally invasive 'step-up approach' versus maximal necrosectomy in patients with acute necrotising pancreatitis (PANTER trial): design and rationale of a randomised controlled multicenter trial [ISRCTN13975868].

BACKGROUND: The initial treatment of acute necrotizing pancreatitis is conservative. Intervention is indicated in patients with (suspected) infected necrotizing pancreatitis. In the Netherlands, the standard intervention is necrosectomy by laparotomy followed by continuous postoperative lavage (CPL). In recent years several minimally invasive strategies have been introduced. So far, these strategies have never been compared in a randomised controlled trial. The PANTER study (PAncreatitis, Necrosectomy versus sTEp up appRoach) was conceived to yield the evidence needed for a considered policy decision. METHODS/DESIGN: 88 patients with (suspected) infected necrotizing pancreatitis will be randomly allocated to either group A) minimally invasive 'step-up approach' starting with drainage followed, if necessary, by videoscopic assisted retroperitoneal debridement (VARD) or group B) maximal necrosectomy by laparotomy. Both procedures are followed by CPL. Patients will be recruited from 20 hospitals, including all Dutch university medical centres, over a 3-year period. The primary endpoint is the proportion of patients suffering from postoperative major morbidity and mortality. Secondary endpoints are complications, new onset sepsis, length of hospital and intensive care stay, quality of life and total (direct and indirect) costs. To demonstrate that the 'step-up approach' can reduce the major morbidity and mortality rate from 45 to 16%, with 80% power at 5% alpha, a total sample size of 88 patients was calculated. DISCUSSION: The PANTER-study is a randomised controlled trial that will provide evidence on the merits of a minimally invasive 'step-up approach' in patients with (suspected) infected necrotizing pancreatitis.

Drainage↗

PubMed2005

Perioperative outcome of laparoscopic left lateral liver resection is improved by using staple line reinforcement technique: a case report.

Current laparoscopic stapling technology still cannot prevent bile leakage (<55%) along the resection margin. A new staple line reinforcement technique was used in the present case. This technique incorporates an absorbable polymer membrane into the stapler system, such that it buttresses the transected solid organ. The objectives of this novel procedure are to decrease hemorrhage at the staple line and to prevent bile duct leakage after liver resection. A 47-year-old man followed for status post biliopancreatic diversion with duodenal switch presented with epigastric pain. On imaging, he was found to have a lesion in segment 2-3 of the left lobe of the liver, which measured at least 3 cm in diameter. He was admitted to the hospital to undergo a laparoscopic left lateral liver resection. This procedure involved laparoscopic ultrasonography of the liver and transection of the left liver lobe with endoscopic linear staplers. The staple height of 3.5, 60 mm long, reinforced with an absorbable polymer membrane was used for liver transection to catch the portal branches. This required multiple firings in the liver parenchyma and additional division of some tissue using the Harmonic scalpel. The larger branch in the middle of segment 2-3 and the left hepatic vein were both transected with the novel staple line reinforcement technique. Bleeding or any bile leakage in this area could not be visualized. No drains were left. The patient's postoperative course was uncomplicated, and he was discharged on postoperative day 3. Pathology results showed a cavernous hemangioma of 4.5 cm in diameter. Staple line reinforcement with the absorbable polymer membrane has the potential to decrease staple line hemorrhage and bile leakage.

Abdominal Pain↗

PubMed2004

Intraluminal migration of bovine pericardial strips used to reinforce the gastric staple-line in laparoscopic bariatric surgery.

A 41-year-old morbidly obese woman (BMI 40.8) underwent elective laparoscopic biliopancreatic diversion with duodenal switch. The operation involved: sleeve gastrectomy, division of duodenum, creation of a duodenoenterostomy, and creation of a distal ileoenteric anastomosis. With laparoscopic stapling, bleeding is often a problem along the sleeve gastrectomy staple-line. To reduce this risk, we used bovine pericardial strips to reinforce the staple-line throughout its length. 4 weeks postoperatively, the patient was found to have fragments of pericardium in her vomitus, indicating intraluminal migration of the reinforcing strips. Her subsequent course has been uneventful. This represents the first report of such migration. Indications, benefits, complications and risks of using bovine pericardium to reinforce gastric staple-lines in laparoscopic bariatric surgery are discussed.

Adult↗

PubMed2004

Staple-line reinforcement techniques with different buttressing materials used for laparoscopic gastrointestinal surgery: a new strategy to diminish perioperative complications.

Many techniques have been analysed to reduce the risk of perioperative anastomotic leakage and bleeding. No specific resection technique with either linear or circular stapling devices has been shown to be superior in preventing these complications. Reinforcement of staple lines with various buttressing materials is a new strategy used to diminish or eliminate anastomotic leaks and haemorrhage. In this chapter, varying reinforcement techniques with different materials are compared. The available literature has been reviewed thoroughly for relevant data regarding stapled reinforcement techniques and minimizing anastomotic leaks and haemorrhage. Reported data show non-absorbable, semi-absorbable, and bioabsorbablematerials available for gastrointestinal (GI) resections. Semi-absorbable xenomaterials (Bovine Pericardial Strips and Bovine Collagen Strips; Shellhigh No-Reaction Vascupatch, Milburn, NJ, USA), non-absorbable expanded polytetrafluoroethylene (ePTFE; W.L. Gore, Elkton, MD, USA) and absorbable poly (L-lactic acid-co-epsilon-caprolactomne) film are compared. Non-absorbable and semi-absorbable materials show many differences. Absorbable polymer membranes demonstrate marked benefits. Staple-line reinforcement used for laparoscopic GI surgery is a relatively new strategy, most probably improving perioperative outcome only if proper buttressing material is used. To decrease anastomotic complications, using an absorbable polymer membrane as staple-line reinforcement material is reliable and efficacious.

Biocompatible Materials↗

PubMedDate not supplied

Decreased bleeding after laparoscopic sleeve gastrectomy with or without duodenal switch for morbid obesity using a stapled buttressed absorbable polymer membrane.

BACKGROUND: Laparoscopically performed sleeve gastrectomy may be employed as an adjunct to biliopancreatic diversion with duodenal switch (BPD-DS), to induce early satiety and weight loss in morbidly obese patients. Complications from this gastric procedure include staple-line leakage or hemorrhage. The efficacy of a staple-line buttressing material, an absorbable polymer membrane (Seamguard, Gore), in reducing these complications, was investigated. METHODS: A prospective consecutive series of 20 patients who underwent a laparoscopic sleeve gastrectomy in conjunction with BPD-DS were studied. In 10 patients, the absorbable polymer membrane was integrated into the gastric linear staple-line (group A). In a control group of 10 patients, a conventional linear stapling system was used (group B). The following data were recorded: demographics, intraoperative blood loss, staple-line leakage and hospital stay. RESULTS: Demographic profile was similar in both groups. Operative data, including type, duration and strategy of operation as well as surgeon's experience were well matched. Peroperative blood loss (120 ml vs 210 ml) was significantly higher in group B (P <0.05). Median length of hospital stay was 3.8 days (range 2-8 days) in group A and 4.6 days (range 4-12 days) in group B. There was no mortality. Morbidity was encountered in 3 patients (all group B), including 2 staple-line hemorrhages (10%) and 1 subphrenic abscess (5%). CONCLUSION: These early results may show that Seamguard reduces staple-line hemorrhage and leakage. This may have contributed to shorter hospital stay, decreased costs and lower morbidity after laparoscopic bariatric surgery.

Absorbable Implants↗