Biomedical subjects

Eugene K Wai

Publications and source records attributed to Eugene K Wai.

7 recordsLinked to original sources

PubMed2006

The International Society for the Study of the Lumbar Spine: research trends over time and publication rates.

STUDY DESIGN AND OBJECTIVES: A retrospective review was conducted to assess trends in research selected for podium presentation at ISSLS. SUMMARY OF BACKGROUND DATA: Abstracts of past papers presented to ISSLS provide quantified documentation of trends in research as well as insight into future directions. METHODS: A systematic review of abstracts of research presented was performed. Graphical plots in each category of research and aspects of study quality were used to identify any trends. Univariate and multivariate logistical regression analyses were used to identify factors related to eventual publication. RESULTS: A total of 43% of selected papers focused on the disc, representing the single largest area of research. There is a linear trend over time toward increased selection of basic science papers and decreased clinical papers. Experimental research design is becoming more frequently selected. In 1978, over 80% of papers were purely descriptive. By 2002, 42% of papers were descriptive, whereas 40% incorporated an experimental design. However, over the past decade, there has been a linear increase in the proportion of randomized controlled trials among clinical papers compared with basic science or biomechanical papers. A total of 54% of all abstracts presented recently went on to publication. Independent factors that were associated with significantly (P < 0.05) higher publication rates included use of blinded or independent observers (84.6%), experimental design (68.4%), basic science or biomechanical papers (62.3%), and statistically positive result (61.8%). CONCLUSION: Overall, the type of research selected for presentation at ISSLS has improved over the years in regards to greater use of experimental and randomized study design. The eventual publication rates compare favorably to other research societies. Factors related to publication have been identified and should be considered in future research.

Humans↗

PubMed2006

Magnetic resonance imaging 20 years after anterior lumbar interbody fusion.

STUDY DESIGN: A 20-year magnetic resonance imaging (MRI) and functional outcome follow-up study was performed on patients who had undergone anterior lumbar interbody fusion. OBJECTIVES: The objectives of the present study are to determine whether or not degeneration is related to adjacent level fusion and the clinical significance of this degeneration. SUMMARY OF BACKGROUND DATA: There are concerns that lumbar fusion leads to increase stress at the adjacent levels. However, the clinical significance of this remains unclear. METHODS: Thirty-nine patients who underwent lower lumbar anterior lumbar interbody fusion and who had normal preoperative discograms at the level adjacent level were evaluated with a minimum of a 20-year follow-up. MRI scans were performed and independently evaluated for any evidence of degeneration. Functional status was assessed using the Low Back Outcome Scale. RESULTS: Twenty-nine (74.3%) patients had some evidence of degeneration in their lumbar spine and advanced degeneration was identified in 12 (30.7%) patients. Nine (23.1%) patients had advanced degeneration isolated to the adjacent level and 7 (17.9%) patients had evidence of advanced degeneration with preservation at the level adjacent to the fusion. There was no association between function and radiographic degeneration. Only 3 patients required additional surgery as a result of adjacent level degeneration. CONCLUSION: The prevalence of degenerative changes is similar to other studies involving normal asymptomatic subjects. Furthermore, the majority of degenerative changes seen occurred over multiple levels or at levels not adjacent to the fusion, suggesting that changes seen may be more likely related to constitutional factors as opposed to the increased stresses arising from the original fusion.

Follow-Up Studies↗

PubMed2004

Risk of stroke in women exposed to low-dose oral contraceptives: a critical evaluation of the evidence.

BACKGROUND: Use of the oral contraceptive pill (OCP) has been reported to be associated with stroke. With current OCPs containing less than 50 micro g of ethinyl estradiol, and many earlier studies reporting the association between OCPs and stroke, subjected to biases, we determined whether such an association exists and, if so, the magnitude of the risk. METHODS: Two independent searches were conducted to obtain relevant articles from MEDLINE, EMBASE, and Science Citation (1970 to June 2000). Eligible articles published in English describing OCP use and stroke outcomes were retrieved, and relevant data were abstracted. Pooling of results from these studies was performed using odds ratios (ORs) provided, and heterogeneity was calculated using chi(2) analysis. RESULTS: From 779 potential articles, 36 eligible studies describing 20 distinct populations were retrieved (4 cohort and 16 case-control studies). The pooled OR from the cohort studies demonstrated no increased stroke risk with OCP use (0.95; 95% confidence interval [CI], 0.51-1.78; P =.01); the pooled OR from the case-control studies showed a significant association (2.13; 95% CI, 1.59-2.86; P<.001). The risk of stroke with OCP use, however, was significant only with thrombotic stroke (2.74; 95% CI, 2.24-3.35; P =.009) and not with hemorrhagic stroke or stroke death. There was statistically significant heterogeneity among these studies, and potential biases and confounders were not adequately addressed. CONCLUSIONS: These results cast doubt on a true association between low-dose OCPs and stroke because of the low absolute magnitude of the ORs, the severe methodological limitations, and the ORs of less than 1.0 in the cohort studies. The association is tenuous at best and perhaps nonexistent.

Adult↗

PubMed2003

Quality of life in surgical treatment of metastatic spine disease.

STUDY DESIGN: Overall quality of life after surgical management of metastatic disease of the spine was prospectively assessed using a validated global health status quality-of-life instrument-the Edmonton Symptom Assessment Scale. OBJECTIVES: To prospectively evaluate the efficacy of surgery in patients with metastatic spinal disease with respect to quality of life. SUMMARY OF BACKGROUND DATA: Management of spinal metastases is palliative and is aimed at improving quality of life at an acceptable risk. Although previous studies have evaluated physical outcomes, improvements in pain, and neurologic function after surgery, a multidimensional assessment of quality of life is more relevant in the palliative patient. METHODS: Twenty-five consecutive patients undergoing surgery for spinal metastases were prospectively evaluated. Pre- and postoperative assessments were performed using the Edmonton Symptom Assessment Scale. The surgical procedure consisted of decompression and instrumented stabilization. RESULTS: After surgery, the largest improvement was noted in the domain of pain (P < 0.00001). There were also significant improvements noted in the domains of tiredness (P = 0.004), nausea (P = 0.01), anxiety (P = 0.006), drowsiness (P = 0.044), appetite (P = 0.02), and well-being (P = 0.004). CONCLUSIONS: The current study demonstrates that in the appropriate patient, surgical management brings about a positive effect on the overall quality of life in patients with spinal metastases. The greatest benefit occurred in the reduction of a patient's level of pain.

Adult↗

PubMed2003

Single-level fixation of flexion distraction injuries.

Flexion distraction injuries of the thoracic and lumbar spine can be stabilized with a short construct spanning one motion segment. This surgical technique has not been well accepted because of the paucity of published outcomes of patients treated in this manner. The current study is a cohort of patients who underwent a standardized posterior open reduction and single-level fixation for this injury pattern. Independent observation prospectively followed the cohort for a minimum of 20 months with functional and radiologic outcomes determined. A significant (p < 0.0001) correction of deformity was achieved, from a mean preoperative kyphosis of 10.1 degrees to a mean postoperative lordosis of 0.9 degrees. No loss of correction occurred. The mean Oswestry score was 11.5, with 88% of patients having minimal disability. This prospective study demonstrates the efficacy of posterior open reduction and single-level fixation of flexion distraction injuries.

Adolescent↗

PubMed2002

Arthroscopic débridement of the knee for osteoarthritis in patients fifty years of age or older: utilization and outcomes in the Province of Ontario.

BACKGROUND: There is little available information regarding the effectiveness of arthroscopic knee débridement for the treatment of arthritis. The purpose of this study was to evaluate patterns of utilization of arthroscopic knee débridement and outcomes following that procedure for the treatment of degenerative arthritis in persons fifty years of age or older in the Province of Ontario. METHODS: All patients fifty years of age or older who underwent elective arthroscopic knee débridement for the treatment of degenerative arthritis between 1992 and 1996 were identified from administrative data sets. Surgical complications and subsequent knee replacements were noted. Population rates were compared across the sixteen District Health Council regions within Ontario. Outcomes were modeled as a function of patient age, gender, and comorbidity with use of multivariate regression analysis. RESULTS: We identified 14,391 eligible unilateral arthroscopic knee débridement procedures. There was a threefold difference in the population rate of arthroscopic débridement across geographic regions. Overall, 1330 (9.2%) of all patients required total knee arthroplasty within one year after the débridement. Of the 6212 patients with a minimum three-year follow-up, 1146 (18.4%) had undergone total knee replacement within three years following the débridement. Patients who were at least seventy years of age were 4.7 times more likely to have total knee arthroplasty within one year after the débridement than were those less than sixty years of age (19.0% compared with 4.0%; p < 0.05). Patients sixty years of age or older were more likely to have an early total knee replacement (within one year after the débridement) in District Health Council regions where the population rates of arthroscopic knee débridement were higher (p = 0.04). CONCLUSIONS: The higher rates of early total knee arthroplasty and the significant relationship between rates of early total knee arthroplasty and rates of utilization suggest that arthroscopic débridement for the treatment of osteoarthritis of the knee may be overutilized in elderly patients. Important clinical issues such as patient preference, risk perception, and functional outcome cannot be addressed just with the administrative data used for this study.

Age Factors↗

PubMedDate not supplied

The relationship between function, self-perception, and spinal deformity: Implications for treatment of scoliosis in children with spina bifida.

The purpose of this study was to determine the relationship of spinal deformity with physical function and self-perception in children with spina bifida. Ninety-eight eligible children with scoliosis and spina bifida were identified; 80 of them (82%) consented to participate. Spinal deformity was measured in many ways, including scoliosis, coronal balance, and pelvic obliquity. Measures of physical function included the Sitting Balance Scale, Jebsen Hand Scale, Hoffer Ambulation Scale, the Spine Bifida Spine Questionnaire, and the Activities Scale for Kids (ASK). Self-perception was determined with Harter's Self-Perception Profile. No relationship was found between spinal deformity and overall physical function (ASK). Of all aspects of spinal deformity, only coronal imbalance was significantly related to only one aspect of physical function (ie, sitting imbalance). No aspect of spinal deformity was related to self-perception. In conclusion, surgeons should be clear in their indications for surgery and recognize that in the short term the potential benefit of surgery may be, at best, to improve only sitting balance.

Activities of Daily Living↗