PubMed Health⌕ Search

Biomedical subjects

Eunha Kim

Publications and source records attributed to Eunha Kim.

5 recordsLinked to original sources
PubMed2006

Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif.

A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity conducted on a privileged substructure was demonstrated through the biological evaluation of a small molecule library representing 22 unique core skeletons via in vitro cytotoxicity assay.

Benzopyrans↗
PubMed2006

Fiber-based single-channel polarization-sensitive spectral interferometry.

We present a novel, to our knowledge, fiber-based single-channel polarization-sensitive spectral interferometry system that provides depth-resolved measurement of polarization transformations of light reflected from a sample. Algebraic expressions for the Stokes parameters at the output of the interferometer are derived for light reflected from a birefringent sample by using the cross-spectral density function. By insertion of a fiber-optic spectral polarimetry instrument into the detection path of a common-path spectral interferometer, the full set of Stokes parameters of light reflected from a sample can be obtained with a single optical frequency scan. The methodology requires neither polarization-control components nor prior knowledge of the polarization state of light incident on the sample. The fiber-based single-channel polarization-sensitive spectral interferometer and analysis are demonstrated by measurement of phase retardation and fast-axis angle of a birefringent mica plate.

Journal Article↗
PubMedDate not supplied

Optical coherence tomography speckle reduction by a partially spatially coherent source.

Speckle in optical coherence tomography (OCT) images originates in the high spatial coherence of incident light that enables interference of light backscattered from spatially heterogenous tissue specimens. We report results of a numerical simulation and an experiment to test speckle reduction using a partially spatially coherent source. A Gaussian-Schell model for a partially spatially coherent source is used in the OCT simulation. For the experiment, such a source was generated by a spatially coherent boardband light source and a multimode fiber. The advantage of using a multimode fiber in combination with a broadband source is the large number of photons per coherence volume. To illustrate speckle reduction with a partially spatially coherent source, we record low-coherence interferograms of a scattering surface using single-mode and multimode source fibers. Interferograms recorded using a single-mode source fiber are indicative of those observed using conventional OCT. Speckle in OCT images recorded using a multimode source fiber is substantially reduced.

Algorithms↗