Biomedical subjects
Publications and source records attributed to Evelyn Strauss.
A large study by the MAQC consortium has established that different DNA microarray platforms can generate reproducible lists of differentially expressed genes. Now scientists are grappling with the challenges of moving the technology toward the clinic.
Programmed proliferative degeneration of the human fetal ductus arteriosus (DA) in preparation for its definite postnatal closure has a large developmental variability and is controlled by several signaling pathways, most prominently by prostaglandin (PG) metabolism. Numerous studies in various mammalian species have shown interspecies and developmental differences in ductal protein expression of cyclooxygenase (COX) isoforms and PG E receptor subtypes (EP1-4). We examined COX1, COX2, and EP4 receptor protein expression immunohistochemically in 57 human fetal autopsy DA specimens of 11-38 wk of gestation. According to their histologic maturity, specimens were classified into four stages using a newly designed maturity score that showed that histologic maturity of the DA was not closely related to gestational age. COX1 expression was found in all DA regions and rose steadily during development. COX2 staining remained weak throughout gestation. EP4 receptor staining increased moderately during gestation and was limited to the intima and media. In conclusion, histologic maturity classification helps to address developmentally regulated processes in the fetal DA. Concerning prostaglandin metabolism our findings are in line with animal studies, which assigned COX1 the predominant role in the DA throughout gestation. EP4 receptor presumably plays a key role for active patency of the human DA in the third trimester.
This article serves as a eulogy for the Science of Aging Knowledge Environment (SAGE KE). This online resource--Science's Web site on aging--is publishing its last issue today. The piece is a personal recollection of co-creating the site--and includes some thoughts on how the field of aging has changed over the last six years.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The Science of Aging Knowledge Environment (SAGE KE) was launched in October 2001 to provide an online information source and community-building tool. The site offers a wide range of features, including original commentary articles, a database of genes and interventions related to aging, and a calendar of meetings and events. Users may initiate discussions and post comments on the articles; these features are intended to promote interaction between researchers in the field and to ensure the timeliness of information posted. This paper details SAGE KE's contents and offers suggestions about how to customize the site to save time and maximize information acquisition and exchange.
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