Biomedical subjects

Evert Thiery

Publications and source records attributed to Evert Thiery.

5 recordsLinked to original sources

PubMed2005

Gender mix: does it modify birthweight--outcome association?

Gender mix, especially the supposed hormone transfer in utero of the male fetus to his female co-twin, is a highly debated controversial subject. It occurs in animals (free-martin syndrome in the cow) but its existence in man has not been convincingly demonstrated. Two aspects of gender mix effects in man, birthweight and cognitive development, were studied in the Belgian East Flanders Prospective Twin Survey, a large population-based registry of multiple maternities, characterised by accurate data on pregnancy, placental structure and zygosity. The birthweight of the female member of the pair is not influenced by the male co-twin but, unexpectedly, the female twin enhances to a slight degree the birthweight of her male co-twin by prolonging the gestation for a few days. Also unexpectedly, in an opposite direction, the cognitive development, as measured by the IQ (WISC-R) of the female twin rises as compared with controls if her birthweight exceeds that of her male co-twin.

Birth Weight↗

PubMed2003

Neurostimulation for refractory epilepsy.

Neurostimulation is an emerging treatment for refractory epilepsy. To date the precise mechanism of action remains to be elucidated. Better insight in the mechanism of action may identify seizure types or syndromes that respond to such a treatment and may guide the search for optimal stimulation parameters and finally improve clinical efficacy. In the past ten years some progress has been made through neurophysiological, neuroanatomical, neurochemical and cerebral blood flow studies in patients and animals undergoing vagus nerve stimulation (VNS). Interesting results have been found in VNS-treated patients that underwent evoked potential measurements, cerebrospinal fluid investigation, neuropsychological testing and PET, SPECT and fMRI testing. Desynchronisation of abnormal synchronous epileptic activity is one of the hypotheses on the mode of action that might primarily be responsible for an anti-seizure effect. There is however increasing evidence from research and clinical observation that VNS might establish a true and long-term anti-epileptic effect. It has been shown that VNS influences neurotransmission in the brain and provokes long-term changes in cerebral blood flow in areas crucial for epileptogenesis such as the thalamus and medial temporal lobe structures. Deep brain stimulation (DBS) for epilepsy has regained interest. Central nervous system structures known to play a key role in the epileptogenic network such as the thalamus and subthalamic nucleus have been targeted. Another approach is to target the ictal onset zone such as the medial temporal lobe. At Ghent University Hospital 10 patients have been treated with long-term amygdalohippocampal DBS. Several hypotheses have been raised for the mechanism of action of DBS for refractory seizures. Seizure reduction may be due to a microlesion caused by electrode insertion or by provoking a reversible functional lesion due to the effect of electrical current on hyperexcitable tissue. Neurophysiological techniques such as evoked potentials monitoring and intraoperative single unit potential recordings may guide correct electrode placement, individual DBS titration and elucidation of the mechanims of action of DBS for epilepsy.

Animals↗

PubMed2002

Rate of change of angular bearing as the relevant property in a horizontal interception task during locomotion.

The authors ran 3 experiments to investigate how catchers deal with the horizontal component of the ball's trajectory in an interception task during locomotion. The experiments were built upon the finding that velocity adaptations are based upon changes in the horizontal angular position or velocity of the ball with respect to the observer (M. Lenoir, M. Janssens, E. Musch, E. Thiery, J. Uyttenhove, 1999) a potential underlying information source for that strategy is described. In Experiment 1, actor (N = 10 participants)and ball approached each other along the legs of a V-shaped track. When the velocity and the initial angular bearing of the ball were varied, the observed behavior fitted with nulling the horizontal angular velocity of the ball: A positive or negative angular velocity was compensated by a velocity change. Evidence was obtained that those adaptations are modulated by a critical change in, rather than by a critical state of, the environment-actor system. In Experiment 2, the distance between the head and an artificial end-effector was varied. Irrespective of that distance, participants (N = 7) accelerated and decelerated in order to keep the angular velocity of the ball with respect to the end-effector close to constant. The ecological relevance of that constant bearing angle strategy was confirmed in Experiment 3: Participants (N = 7) in that experiment freely ran to catch fly balls. The present results support the concept that one can explain with a limited number of control variables an actor's behavior in an interception task during self-motion.

Adult↗

PubMed2002

The East Flanders Prospective Twin Survey (EFPTS).

The East Flanders Prospective Twin Survey (EFPTS) is a registry of multiple births in the province of East-Flanders, Belgium. It has several unique features: it is population-based and prospective, with the possibility of long-term follow-up; the twins (and higher order multiple births) are ascertained at birth; basic perinatal data are recorded; chorion type and zygosity are established; and since 1969 placental biopsies have been taken and frozen at -20 degrees C for later determination of genetic markers. The EFPTS is the only large register that includes placental data and allows differentiation of three subtypes of monozygotic (MZ) twins based on the time of the initial zygotic division: the dichorionic-diamnionic pairs (early, before the fourth day after fertilisation), the monochorionic-diamnionic pairs (intermediate, between the fourth and the seventh day post fertilisation), and the monochorionic-monoamnionic pairs (late, after the eight day post fertilisation). This added a new dimension to didymology (the science of twins; delta iota delta upsilon mu omicron zeta = twins): the timing of twinning. Studies can be initiated on primary biases, those originating "in utero". Such studies may throw new light on the controversy over the validity of the classic twin method, the consequences of early embryological events (before and just after implantation of the embryo), the origin of congenital malformations, the sex proportion of multiples, the gene-environment interactions as far as intrauterine environment is concerned, to name but a few.

Belgium↗

PubMedDate not supplied

Vagus nerve stimulation for refractory epilepsy: a transatlantic experience.

Vagus nerve stimulation (VNS) is an alternative treatment for medically or surgically refractory epilepsy. The long-term efficacy and safety of VNS were evaluated in a large patient series at Ghent University Hospital and Dartmouth-Hitchcock Medical Center. Between March 1995 and February 2003, seizure frequency and type as well as prescribed antiepileptic drugs and side effects were prospectively assessed in 131 patients treated with VNS in either center. Patients with a minimum follow-up duration of 6 months were included in the efficacy and safety analysis. A total of 118 of 131 implanted patients had a minimum postimplantation follow-up period of 6 months (mean, 33 months). The mean age of these patients was 32 years and the mean duration of refractory epilepsy was 22 years. The mean reduction in monthly seizure frequency in all patients was 55% (range, 0-100; SD = 31.6). Seven percent of patients were free of seizures with impaired consciousness, 50% of patients had a seizure frequency reduction of more than 50%, and 21% of patients were nonresponders. Fifteen patients reported stimulation-related side effects such as hoarseness or gagging. In a large patient series from two geographically distinct epilepsy centers located in two different continents, VNS proved to be efficacious and safe during long-term follow-up.

Adolescent↗