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Ewa Kazimierska

Publications and source records attributed to Ewa Kazimierska.

7 recordsLinked to original sources
PubMed2006

[Multi-reasons, severe megaloblastic anaemia--description of two cases].

We report two cases of young patients (44 and 26 years old) with severe macrocytic, megaloblastic anaemia in course of Addison-Biermer's disease. In addition we found also other reasons of vitamin B12 deficiency. The one of them was chronic autoimmune thyroiditis and the second was, surely, Helicobacter pylori infection. The presented cases confirm the importance of spreading the diagnosis with antithyroid antibodies detection and Helicobacter pylori test in all patients with Addison-Biermer's diseaese.

Adult↗
PubMed2006

[Thrombocytopenia and other extrahepatic manifeststions of hepatitis C virus infection--case report].

Authors present a case of forty seven years old woman with thrombocytopenia in the course of hepatitis C virus infection. Thrombocytopenia might be related to immunological mechanisms or be an effect of hypersplenism. Moreover mixed cryoglobulinemia, lymphocytic autoimmune thyroiditis with hypothyroidism and other laboratory abnormalities (impaired rate of lymphocytes CD4 to CD8, increase of B cells and natural killer cells, hypocomplementemia, hypergammaglobulinemia, increase of immune complexes concentration) were revealed. Above-mentioned abnormalities might be an effect of hepatitis C virus infection.

Autoimmune Diseases↗
PubMed2005

[Portal vein thrombosis in patients with thrombophilia--own observations].

Portal vein thrombosis is one of the main prehepatic causes of portal hypertension. The most frequent causes of thrombosis in this localization, apart from hepatic cirrhosis, are the following: acute inflammatory diseases and abdominal cancers, traumas, proliferative diseases of the hematopoietic system. In recent years attention was given to disorders in hemostasis, such as thrombophilia, in the course of which thrombosis development is particularly common. The authors present 10 patients after an incident of portal vein thrombosis, in which primary hepatic pathology was excluded and tests directed at thrombophilia were performed. In seven patients abnormalities in the examined parameters were found, and what is more, in two cases they had a complex character and involved more than one parameter. In five patients hyperhomocysteinemia was found. Among them, in two patients there was also a decreased protein S activity and in one of them there was also APC-resistance. In the next two patients there were abnormalities in one of the examined parameters - APC-resistance. Hyperhomocysteinemia was found in all patients with idiopathic thrombosis, and in one of them there were concurrent changes in protein S activity and APC-resistance. In patients with the history of portal vein thrombosis diagnostics of thrombophilia should be performed.

Adult↗
PubMed2005

[Negative D-dimers and exclusion of venous thromboembolism--own experience].

The assessment of D-dimer concentration has become essential step during diagnostic algorithm of venous thromboembolism (VTE). This test characterizes high sensitivity but limited specificity. Negative D-dimer with high probability excludes VTE. The aim of this study was to assess the percentage of patients treated in Department of Internal Medicine, Endocrinology and Haemostatic Disorders, Medical University of Gdańisk, who in spite of clinical signs of VTE showed normal D-dimer level. Between 2000 and 2004 in our department 57 cases with recent deep vein thrombosis (DVT) were diagnosed, in 2 cases with co-existence of pulmonary embolism (PE). The D-dimer concentration was assessed in patients' plasma with the use of immunoturbidometry. Between 57 cases with VTE, 7 patients (12%) showed normal D-dimer level (<500 microg/ml). This group consisted of 4 men and 3 women, aged from 40 to 82 years (the mean age of 58 years). In all 7 cases DVT was diagnosed, in 2 patients with concomitent PE. The final diagnosis was confirmed by compression ultrasonography and pulmonary scintigraphy. Our analysis underlines the observation that occurrence of VTE and negative d-dimer concentration is possible and may probably be related to methodological limitations. However, the lack of increase of D-dimer could also be caused by fibrinolysis alteration.

Adult↗
PubMed2004

[Macrocytic megaloblastic anaemia in a patient with Helicobacter pylori infection].

We present 62 yrs old patient in whom megaloblastic anaemia due to vitamin B12 depletion was caused by Helicobacter pylori infection. An eradication treatment with the vitamin B12 supplementation within 7 days resulted in withdrawal of the abnormalities in the blood smear. The inflammation of gastric mucosa with intestine metaplasia is still observed. According to the letters these changes may persist up to 2-3 years after treatment ending.

Anemia, Megaloblastic↗
PubMed2003

[Serum homocysteine, vitamin B12 and folic acid concentrations in patients with alcoholic liver cirrhosis].

The aim of the work was to establish serum homocysteine, vitamin B12 and folic acid concentrations in patients with alcoholic liver disease. Mentioned above vitamins are enzymatic cofactors for metabolic changes of homocysteine. It is a common fact that alcoholics often present with avitaminosis. Additionally, damaged liver worsens this pathology what can negatively influence metabolism of homocysteine. 40 patients--(mean age 52.7 years) and 40 healthy individuals (mean age 50.3 years) were examined. Hyperhomocysteinemia (concentration > 12 mmol//l) was stated in 50% of the patients and mean homocysteine concentration was statistically significantly higher if compared to the controls (13.29 +/- 8.16 vs 11.03 +/- 1.6 mmol/l p < 0.05). In the female patients homocysteine concentration was significantly higher than in the healthy controls (14.6 +/- 10.63 vs 10.73 +/- 1.37 mmol/l p < 0.001). A negative correlation between homocysteine concentration and folic acid concentration in the group of the patients with hyperthomocysteinemia was observed (r = -0.88, p < 0.001) and among all the patients (r = -0.312, n.s.). Vitamin B12 levels were significantly higher in the group of patients than in the controls (659.43 +/- 489.27 vs 384.44 +/- 145.93 p < 0.001) what is consistent with the data from the literature. A positive correlation between mean homocysteine concentration, age and platelet count of the examined patients was stated (r = 0.350, p < 0.05, r = 0.508, p < 0.001). On the basis of the obtained results one can conclude that hyperthomocysteinemia is often established in alcoholic liver disease. Partially, low folic acid concentration is responsible for this fact. In theoretical deliberation one should consider estimation of betaine metylotransferasis levels--the enzyme which is responsible for homocysteine metabolism in the liver.

Female↗