PubMed Health⌕ Search

Biomedical subjects

F A Ali

Publications and source records attributed to F A Ali.

8 recordsLinked to original sources
PubMed1999

A clinical and neurophysiological study of scorpion envenomation in Assiut, Upper Egypt.

Scorpion envenomation (SE) represents an agonizing problem in many countries, especially in rural areas. This clinical and neurophysiological study aimed to determine the relative frequency of scorpion envenomation in the Assiut area, in Upper Egypt. Full clinical evaluation was carried out for all children < or =18 y of age included in the study. Electroencephalography (EEG), electromyography (EMG) and motor conduction velocity measurements were carried out for a variable number of children. SE was recorded in 302 cases per year in this area. Of these, 78.5% were < or =18 y of age. SE occurred most commonly during the summer months. Clinical evaluation revealed that SE results in marked autonomic manifestations, principally sinus tachycardia (78.1%), vomiting (70.5%) and hyperthermia (53.2%). It also results in many neuropsychiatric manifestations, such as agitation and restlessness (17.7%) and disturbance of consciousness (8.0%). Electroencephalographic study of 184 cases of SE in paediatric patients aged < or =18 y revealed abnormalities in 77.7%. Study of mean distal latency and motor conduction velocity revealed that patients had a significantly shorter distal latency and a more rapid motor conduction velocity compared with the control group. This was true for both the inflicted limb and the contralateral limb. Most of the complications of SE are due to irritability of the central and peripheral nervous systems.

Adolescent↗
PubMed1998

Imaging patterns of neonatal hypoglycemia.

PURPOSE: Our purpose was to report the patterns of injury observed in five patients who suffered brain damage consequent to neonatal hypoglycemia. METHODS: The imaging studies and clinical records of five patients with brain damage caused by neonatal hypoglycemia were reviewed retrospectively. Patterns of injury were compared with those described in the literature and those seen in neonatal hypoxic-ischemic injury. RESULTS: Diffuse cortical and subcortical white matter damage was seen, with the parietal and occipital lobes affected most severely. Globus pallidus injury was present in one patient who had the most severe cortical injury. CONCLUSION: We found a specific pattern of injury that correlates well with the sparse pathologic and imaging reports on neonatal hypoglycemia. We speculate that the patterns of damage are the result of regional hypoperfusion and excitatory toxicity with cell-type-specific injury.

Brain↗
PubMed1998

A novel synthesis of fused pyrazole systems as antimicrobial agents.

The pyrazolo[3,4-b]pyridine derivatives 3 could be prepared by condensing compounds 1 with the 3-aminopyrazolone derivative 2. The pyrazolo[5,2-b]-1,3-oxazine derivative 11 and polyfunctionally substituted 1,4-dihydropyridines 15, 18 were also synthesized. Some of the obtained compounds were tested for their antimicrobial activity.

Anti-Bacterial Agents↗
PubMed1992

Pathological changes in testes and liver of male albino rats after dermal exposure to DDVP insecticide.

Exposure of male albino rats to DDVP insecticide at sublethal dose of 30 mg/kg/day through dermal painting for a period of 90 days didn't show any intoxication symptoms or mortality. However, cytopathological changes in testicular and liver tissues were evident. There was a positive correlation between the degree of cellular damage and the period of insecticide administration. In general, damages were prominent in rats treated for 30 days or more. Histological examination of testes showed degenerative seminiferous tubules and fewer leydig cells. Hepatic cells were congested, atrophied and showed different stages of necrobiotic changes. This suggests a great care and caution for workers during different phases of DDVP insecticide handling.

Administration, Topical↗
PubMed1984

Morphological alterations of rat lung bronchiolar epithelium produced by various trialkyl phosphorothioates.

A single oral administration of O, O, S-trimethyl phosphorothioate (OOS-Me), an impurity in widely used organophosphorus insecticides, causes delayed toxicity (delayed death) which is accompanied by morphological changes in the bronchiolar epithelium of rat lungs. A series of simple O,O-dimethyl and O,O-diethyl S-alkyl phosphorothioate esters, which induce delayed toxicity, were examined for their effect on rat bronchiolar epithelium. The structural analogues synthesized and tested include O, O-dimethyl S-ethyl phosphorothioate, O,O-dimethyl S-isopropyl phosphorothioate, O,O,S-triethyl phosphorothioate, and O,O-diethyl S-methyl phosphorothioate. The present investigation demonstrated that these analogues of OOS-Me which cause delayed toxicity produce body weight loss, accompanied by morphological alterations of terminal bronchiolar epithelium, i.e. loss of the apical bulge of non-ciliated Clara cells. Another impurity which produces delayed toxicity, O,S,S-trimethyl phosphorodithioate, was also capable of producing similar effects at near the LD50 level.

Administration, Oral↗
PubMedDate not supplied

Toxicological properties of O,O,S-trialkyl phosphorothioates.

The effect of atropine, 2-pyridine aldoxime methiodide (2-PAM), and several O,O,O-trialkylphosphorothioates on poisoning of rats by a series of O,O-dimethyl and O,O-diethyl S-alkyl phosphorothioates was investigated. Atropine and 2-PAM successfully protected rats treated with O,O-diethyl S-n-propyl and S-i-propyl phosphorothioates, while the O,O,O-trialkyl phosphorothioates were effective in protecting rats treated with O,O-dimethyl S-methyl and S-ethyl phosphorothioates. O,O-Dimethyl and O,O-diethyl S-i-propyl phosphorothioates also were examined for in vitro and in vivo inhibition of rat plasma, red blood cell, and brain cholinesterase. Overall, the results indicated that two different mechanisms, cholinergic and noncholinergic, are involved in intoxication by the O,O,S-trialkyl phosphorothioates.

Animals↗
PubMedDate not supplied

Cesarean section in grandmultiparas.

Grandmultiparity which has been considered to be a factor in maternal and neonatal morbidity [3], is still high in Libya as compared with European countries. A retrospective study of one aspect of this problem concerned the Cesarean section in patients who had delivered 6 or more babies. During the period of January Ist to the end of December 1993, the records of all grandmultiparous women who delivered by a Cesarean section (287 cases) were reviewed at Obstetric Department of University Hospital in Benghazi-Libya. The incidence was 7.9%. The most common indications for the Cesarean section were: fetopelvic disproportion or failure to progress (26.5%), previous Cesarean sections (19.5%), malpresentation (16%), placenta praevia and failed induction for each of them (7%). The perinatal mortality was 17/1000. We conclude that grandmultiparas require Cesarean sections more frequently than nongrandmultiparas, especially primary and emergency Cesarean sections. For such patients an effective family planning program is necessary.

Adult↗