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Biomedical subjects

F A Baker

Publications and source records attributed to F A Baker.

6 recordsLinked to original sources
PubMed1986

The optic tectum regulates the transport of specific proteins in regenerating optic fibers of goldfish.

The pattern of rapidly-transported proteins in regenerating optic fibers of the adult goldfish is regulated by interactions between these fibers and their main target, the optic tectum. When the optic fibers are allowed to interact with the tectum, the transport of proteins with molecular weights in the range of 110-145 kilodaltons (kDa) increases, whereas the transport of proteins in the 24-27 kDa range declines from the previously high level which has been induced by axotomy. If the optic fibers are prevented from interacting with the tectum, the transport of the 24-27 kDa proteins remains elevated for months. Amounts of other rapidly-transported retinal proteins (e.g. the acidic 43-49 kDa proteins that increase in regenerating optic fibers after axotomy) are relatively unaffected by tectal ablation.

Animals↗
PubMed1974

Serological studies with purified neuraminidase antigens of influenza B viruses.

Neuraminidase (N) can be extracted from virus particles of influenza B strains by treatment with trypsin, in a form which is free from the viral HA and has specific immunological activity. The N antigen of B/LEE/40 behaves differently from that of 1965-6 strains in gel diffusion and enzyme inhibition tests with animal antisera raised by infection or by artificial immunization with the homologous or heterologous strains. The frequency and titres of NI antibody detected in human sera by B/LEE antigen are different from those found with antigen from B/Eng/13/65. The latter antibody appears to contribute to the effect of serum HI antibody in protecting volunteers exposed to a deliberate intranasal challenge infection of the B/Eng/13/65 strain.

Animals↗
PubMed1973

The efficacy of live and inactivated vaccines of Hong Kong influenza virus in an industrial community. A report to the Medical Research Council Committee on influenza and other respiratory virus vaccines.

Intranasal vaccines of inactivated or living attentuated A2/Hong Kong influenza viruses were compared for clinical acceptability, serological effects and protective efficiency against natural epidemic influenza in a large industrial and clerical population.Neither vaccine resulted in any significant untoward side-effects. The serum haemagglutination-inhibiting (HI) antibody response within 1 month of vaccination was similar with both vaccines; approximately 50% of those with little or no pre-vaccination antibody developed 4-fold or greater rises in titre. The effect of the antigenic potency of the vaccines and the prior immunological experience of the population is discussed. Volunteers given live vaccine showed a 2.2-fold lower incidence of clinical influenza than those given killed vaccine in a natural epidemic 16 months after vaccination.

Antibody Formation↗
PubMed1970

A comparison of monovalent Hong Kong influenza virus vaccine with vaccines containing only pre-1968 Asian strains in adult volunteers. A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines.

A total of 1601 adult industrial workers were vaccinated with either monovalent inactivated vaccine of the Hong Kong strain of influenza A virus, or with polyvalent vaccine containing only pre-1968 Asian viruses. Serological investigations on a random sample of volunteers showed that 53/56 (95%) given Hong Kong vaccine developed a significant rise in specific haemagglutination-inhibiting antibody; final titres were 1/48 or greater in 39 (70%) and the GMT (geometric mean titre) was 96.5. After polyvalent Asian vaccine, 40/67 (60%) also produced antibody against Hong Kong virus, but only 21 (31%) had final titres of 1/48 or above, and the GMT rose only to 14.1. An intranasal spray of the Hong Kong vaccine in addition to injected Asian vaccine gave no additional increase in antibody.Each type of vaccine stimulated a recall of pre-existing antibody against Asian viruses. The possible significance of heterologous responses to the two vaccines is discussed.The incidence of clinical influenza in the trial population was sporadic, and the infection rates were too low to allow any accurate estimate of the protective efficiency of the two vaccines.

Adolescent↗