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Biomedical subjects

F A Chervenak

Publications and source records attributed to F A Chervenak.

At least 19 recordsLinked to original sources
PubMed1992

Ethically justified guidelines for family planning interventions to prevent pregnancy in female patients with chronic mental illness.

OBJECTIVE: This article proposes ethically justified clinical guidelines for family planning interventions to prevent pregnancy in female patients. STUDY DESIGN: We reviewed literature on family planning and consequences of pregnancy in patients with chronic mental illness and related that literature to ethical principles. RESULTS: Patients with chronic mental illness are ethically unique because they have chronically and variably impaired autonomy. Existing guidelines and proposals for family planning interventions for mentally retarded patients are shown not to apply to such patients. CONCLUSION: Three sets of guidelines for three groups of patients, representing the continuum of chronically and variably impaired autonomy, are proposed: (1) a set of guidelines for patients who can achieve thresholds of autonomy, (2) a set of guidelines for patients irreversibly near thresholds of autonomy, and (3) a set of guidelines for patients irreversibly below thresholds of autonomy. These guidelines should contribute significantly to the quality of obstetric and gynecologic care for female patients with chronic mental illness.

Comprehension↗
PubMed1992

Fetal choroid plexus cysts: beware the smaller cyst.

Current literature suggests that amniocentesis be performed on fetuses with simple choroid plexus cysts only when such cysts are 1.0 cm or greater in diameter and bilateral. At retrospective analysis of 3,769 patients, choroid plexus cysts were noted in 87 (2.3%), representing a rate three times greater than that of previous reports. Eight-three patients underwent amniocentesis. Six (7.2%) had abnormal karyotypes. Four patients had the commonly associated chromosomal abnormality trisomy 18. Two had karyotypes not usually associated with this problem: mosaic Turner syndrome and trisomy 21. Of the six patients with abnormal karyotypes, one had a 4-mm-diameter unilateral choroid plexus cyst and three had bilateral cysts of 3-5 mm. Only one patient with a 16-mm cyst had any associated structural abnormality discovered at rigorous ultrasound examination. Karyotyping may be necessary in fetuses with small choroid plexus cysts. Deciding which patients should be encouraged to undergo amniocentesis is made more complex by these data.

Amniocentesis↗
PubMed1992

Prenatal diagnosis of structural anomalies.

The ultrasound diagnoses of fetal anomalies affecting obstetric management were initially made in the early 1970s. Since this breakthrough, ultrasound diagnosis and prenatal management of structural fetal abnormalities have become essential and evolving components of prenatal diagnosis and therapy. In this overview, we review recent contributions in the peer review literature on four controversial topics: choroid plexus cysts, cystic hygroma, ventral wall defects, and hydronephrosis.

Choroid Plexus↗
PubMed1991

The fetus as patient: implications for directive versus nondirective counseling for fetal benefit.

The authors provide an ethical account of the fetus as patient and identify the implications of that account for directive versus nondirective counseling for fetal benefit. They argue that such an account cannot be grounded in the independent moral status of the fetus. Instead, the concept of the fetus as patient is best understood in terms of the principle of beneficence. On the basis of this principle, the fetus is a patient depending on whether links can be established between the fetus and the child it can become. The viable fetus is a patient. Directive counseling for fetal benefit of the viable fetus is appropriate, provided that it takes account of the presence and severity of fetal anomalies, extreme prematurity, and obligations to the pregnant woman. The previable fetus, including the in vitro embryo and the near-viable fetus, is a patient solely as a function of the pregnant woman's autonomous decision to confer such status. If she confers such status, the fetus is a patient and directive counseling is appropriate, provided that it takes account of the factors noted above. If she denies such status, the fetus is not a patient and nondirective counseling is appropriate.

Beneficence↗
PubMed1991

Report of the Council on Scientific Affairs of the American Medical Association: ultrasound evaluation of the fetus.

Ultrasound evaluation of the fetus has become a vital part of prenatal care not only to detect abnormalities of fetal growth, but to diagnose congenital anomalies, hydatidiform mole and ectopic pregnancy, to assess fetal well-being, and finally to provide ultrasound guidance for invasive procedures. This article will discuss the role of fetal ultrasonography as we head into the 1990s, the changing concepts of indications for ultrasound scanning, the increasing sophistication of the technique, and the types of anomalies detected by this imaging method.

American Medical Association↗
PubMed1990

Selective reduction of multifetal pregnancies.

Selective reduction was carried out in 46 multifetal pregnancies by means of potassium chloride injection into the pericardial region of the fetus. There were three indications for the procedure: to improve perinatal outcome and to increase the likelihood that a term infant would be born in a multifetal pregnancy (34 women); to allow the birth of a healthy infant without the birth of a congenitally abnormal coexisting fetus (8 women); and to preserve a singleton pregnancy when the woman would otherwise have the whole pregnancy terminated (4 women). Of the 80 fetuses left after reduction 75 (94%) have survived. In 3 cases ultrasound scanning showed cardiac activity in the injected fetus 20-30 min after the initial injection despite 2 min of asystole immediately after the injection; repeated injection, carried out the same day, led to fetal death in all 3 cases. Selective reduction of multifetal pregnancies for the three indications described is an ethically justifiable option for the management of multifetal pregnancy, to which there are no public policy obstacles.

Congenital Abnormalities↗
PubMed1990

Clinical guides to preventing ethical conflicts between pregnant women and their physicians.

We provide a justification for preventive ethics in obstetric practice. Four clinical guides to resolving ethical conflicts between pregnant women and their physicians can be identified: (1) informed consent as an ongoing dialogue between the pregnant woman and her physician, (2) negotiation as a clinical strategy, (3) respectful persuasion as a clinical strategy, and (4) the proper use of ethics committees.

Beneficence↗
PubMed1990

Does obstetric ethics have any role in the obstetrician's response to the abortion controversy?

We defend the view that the obstetrician's response to the abortion controversy cannot be based on accounts of the independent moral status of the fetus, because all such accounts are irresolvably disputable. That response, however, can be based on an account of the dependent moral status of the fetus. For such an account the central question is, "When is the fetus a patient?" Viable fetuses are patients. Nonviable third-trimester fetuses are not patients. Previable fetuses are patients solely as a function of the woman's autonomous decision to confer such status. The abortion of a viable fetus is, with few exceptions, never ethically justified, because it is a patient. The abortion of nonviable third-trimester fetuses (i.e., premature termination of pregnancy) is justified when the pregnant women consents to it. Abortion of the previable fetus is justifiable when the pregnant women consents to it. We distinguish between professional and private conscience. We identify the limits of the former and the legitimate role of the latter, especially in the area of religious beliefs. Finally, we address the implications of our view for residency training programs. The most important of these implications is that requiring all residents to perform abortions is ethically unjustifiable.

Abortion, Induced↗
PubMed1990

The relationship of maternal erythrocyte oxygen transport parameters to intrauterine growth retardation.

The relation of fetal growth and maternal oxygen transport as assessed by red blood cell 2,3-diphosphoglycerate, hemoglobin oxygen affinity, hemoglobin, pH, and PCO2 was evaluated in 21 pregnant women. The study was performed in the third trimester and each subject evaluated had sonographic evidence of fetal growth retardation without other obvious abnormalities. Decreased maternal 2,3-diphosphoglycerate/hemoglobin molar ratio and hemoglobin oxygen affinity were related linearly to the birth weight normalized for the expected sea level values of gestational age expressed as a birth weight (gestational age-normalized) Z score. The correlation coefficients and p values were r = 0.71, p less than 0.001 and r = 0.67, p less than 0.001, respectively. The ponderal index-normalized Z score correlated with the 2,3-diphosphoglycerate/hemoglobin molar ratio (r = 0.46, p less than 0.04), but the relation was not as strong as the birth weight-normalized Z score. The crown-heel length/head circumference ratio did not correlate with the 2,3-diphosphoglycerate/hemoglobin molar ratio (r = 0.29, NS). The birth weight (gestational age)-normalized Z score did not correlate with hemoglobin, PCO2, or pH. In the regulation of hemoglobin oxygen affinity, calculations indicated that the 2,3-diphosphoglycerate/hemoglobin molar ratio played a highly significant role (p less than 0.001), pH was minimally significant (p less than 0.025), but PCO2 had little or no significant effects in this study. It appears that fetal growth is related to the maternal red blood cell oxygen transport parameters 2,3-diphosphoglycerate/hemoglobin molar ratio and hemoglobin oxygen affinity. Moreover, the 2,3-diphosphoglycerate/hemoglobin molar ratio is the principal regulator of hemoglobin oxygen affinity.

2,3-Diphosphoglycerate↗
PubMed1990

Ultrasound diagnosis of fetal anomalies.

Obstetric ultrasound permits the antenatal diagnosis of structural fetal anomalies. Every pregnant woman should have the option of a second trimester ultrasound examination in centers where examinations are available.

Brain↗
PubMed1990

An ethically justified, clinically comprehensive management strategy for third-trimester pregnancies complicated by fetal anomalies.

We present an ethically justified, clinically comprehensive management strategy for third-trimester pregnancies complicated by fetal anomalies, based on 72 cases diagnosed at a gestational age of more than 24 weeks. These cases are organized into three categories: A) nonaggressive management and termination of pregnancy offered, three of 72 (4%); B) aggressive and nonaggressive management offered, 18 of 72 (25%); and C) aggressive management recommended, 51 of 72 (71%). We then ethically justify a clinically comprehensive management strategy. First, we describe the disclosure requirements of the informed-consent process. Second, we provide an ethical justification for the physician's recommendations among management alternatives. The justification for such recommendations is based on a continuum of beneficence-based obligations to the fetus that is developed in terms of a classification scheme of fetal anomalies, based on the degree of probability of antenatal diagnosis and degree of probability of outcome. When there are no beneficence-based obligations to the fetus, the physician should recommend only termination of pregnancy or nonaggressive management. When there are minimal beneficence-based obligations to the fetus, only aggressive or nonaggressive management should be recommended. Finally, when there are more than minimal beneficence-based obligations to the fetus, only aggressive management should be recommended.

Abortion, Eugenic↗