Biomedical subjects

F A Diaz

Publications and source records attributed to F A Diaz.

3 recordsLinked to original sources

PubMed1979

Organization of a cardiovascular surgical unit: conclusions of an opinion survey among the members of the European Cardiac Surgeons Club (ECSC).

This paper summarizes the opinions of 20 representatives of well-known European centers for adult and pediatric thoracic and cardiovascular surgery regarding the optimal structure and organization of such units. These opinions were collected by means of a questionnaire, and the answers were discussed by the members of the group. Statistical analysis showed a high degree of concordance on the following subjects: The population to be covered by a given center, the relationship between cardiac surgery and cardiology, the minimal number of operations to be performed, the surgical, anaesthesiological and nursing staff, the equipment level required, the surgical training and research, and the cooperation with other centers, Partial concordance of opinions was reached in other aspects, while on some topics widely divergent views were stated, depending, in part, upon regional differences. This material is discussed in detail and we hope it will serve as a guide for the future development in this field both within and outside of Europe.

Adult↗

PubMed1977

Effect of sodium bicarbonate on canine left ventricular function.

Left ventricular performance was evaluated in seven canine right heart bypass preparations during and after the intraauricular administration of sodium bicarbonate (100 ml, 1100 Osm, 60 mEq). Under conditions of constant cardiac input and left ventricular volume, sodium bicarbonate produced mild and brief left ventricular depression, as manifested by a decline of left ventricular dp/dt with simultaneous rise of left ventricular end-diastrolic and left atrial pressures. These findings occurred as aortic impedance fell. Identical results accrued in paced and unpaced preparations. The data lends credence to the proposition that a sudden rise in blood pCO2 produces increased transport of CO2 across the cardiac membranes with intracellular acidosis. However, the data is also compatible with hyperosmolality induced contractile depression. Possible clinical implications are discussed.

Animals↗

PubMed1976

Effects of ketamine on canine cardiovascular function.

Left ventricular contractility was assessed before and during the peak effect of ketamine in eight canine right heart bypass preparations. Myocardial contractility was defined in terms of maximum left ventricular dp/dt, the ejection fraction, and left ventricular end-diastolic and left atrial pressures at constant heart rate and cardiac inflow. Ketamine produced significant decreases in contractility and there were some indications of a dose-response pattern. The action of ketamine was dependent partly on changes in arterial pressure, as the drug caused a mild but sustained vasodilatation which was not dose-dependent. These data offer further evidence of a small and transient negative inotropic effect of ketamine.

Animals↗