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Biomedical subjects

F A Jackson

Publications and source records attributed to F A Jackson.

14 recordsLinked to original sources
PubMed1978

Aerobiological studies based in Derby. I. A simplified automatic volumetric spore trap.

A simplified version of the Hirst automatic volumetric spore trap has been developed in Derby for aerobiological studies. In comparative trials, the number of spores retained by the Morrow Brown trap were similar in the case of larger spores such as Alternaria (102%), rather higher in the case of grass pollen (136%) and considerably higher (166--201%) for very small spores such as Sporobolomyces and Tilletiopsis. Impaction efficiency has been improved by using a narrower slit. The trap designed in Derby is simple to produce and presents advantages in design over the Hirst version.

Air Microbiology↗
PubMed1978

Aerobiological studies based in Derby. II. Simultaneous pollen and spore sampling at eight sites within a 60 km radius.

In order to determine whether a sampling site in the centre of Derby, where air sampling had been carried out for five summers, really provided valid aerobiological data for the surrounding area, eight identical volumetric spore traps were operated simultaneously during the summer of 1969 at various sites up to 56 km from Derby. For most pollen and spore types, total numbers and seasonal pattern at all the sampling sites were found to be similar, although a few extreme and unexpected variations were noted. Figures varied somewhat in different types of site, and local effects are emphasized.

Air Microbiology↗
PubMed1978

Aerobiological studies based in Derby. III. A comparison of simultaneous pollen and spore counts from the east coast, Midlands and west coast of England and Wales.

The air spora of two sites on the east coast of Britain and one on the west coast were compared with each other and with the regular sampling site in Derby by the simultaneous operation of volumetric spore traps. Concentrations of airborne spores and pollen were found to be usually less at the coastal sites than in Derby. The effect of wind direction was shown to be important at coastal sites because daily counts often showed rises and falls corresponding to off- and on-shore winds respectively. Counts at the west coast site were nearly always lower than those on the east. These findings, together with the prevalence of westerly winds over Britain and the different land use in the east and west, suggest that fewer airborne allergens may be encountered on the west coast.

Air Microbiology↗
PubMed1977

Beclomethasone dipropionate aerosol in treatment of perennial and seasonal rhinitis: a review of five years' experience.

1. Five years' experience in the use of beclomethasone dipropionate aerosol (BDA) in the treatment of 315 patients with upper respiratory tract allergy is reviewed. 2. A total of 223 patients with perennial rhinitis was treated. In 23, where the nasal allergy had recurred after oral corticosteroid therapy for asthma was withdrawn, BDA was effective in 69% of cases. A similar success rate (68%) was recorded in 169 patients suffering from perennial allergic rhinitis alone, but a satisfactory response was observed in only 45% of 31 patients with nasal polypi. 3. In 92 patients with seasonal allergic rhinitis freedom from symptoms was achieved in 80%. 4. A total of approximately 534 patient-years of treatment has been recorded without any evidence of side-effects either clinically or on nasal biopsy.

Aerosols↗
PubMed1976

Regulation of the tricarboxylic acid cycle and poly-beta-hydroxybutyrate metabolism in Azotobacter beijerinckii grown under nitrogen or oxygen limitation.

Azotobacter beijerinckii was grown in ammonia-free glucose/mineral salts media in chemostat culture under oxygen or nitrogen limitation. Selected enzymes of the tricarboxylic acid cycle and poly-beta-hydroxybutyrate metabolism were monitored in relation to oxygen supply for both steady and transition states. Two dissolved oxygen concentrations were used for the nitrogen-limited steady state to investigate the possible effects of respiratory protection of nitrogenase on these enzymes. The levels of NADH oxidase, isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase increased markedly on relaxation of oxygen limitation while pyruvate dehydrogenase and citrate synthase were relatively unaffected. beta-Ketothiolase and acetoacetyl-CoA reductase levels decreased as oxygen limitation was relaxed. Respiratory activity, as measured by the QO2 value, increased with oxygen supply rate. Imposition of oxygen limitation on a nitrogen-limited culture caused an immediate increase in the NADH/NAD ratio but this rapidly readjusted to its previous steady-state value. These changes are discussed in relation to respiratory protection of nitrogenase and poly-beta-hydroxybutyrate metabolism in A. beijerinckii.

Acetyl-CoA C-Acetyltransferase↗
PubMedDate not supplied

A comparison of beclomethasone dipropionate aqueous nasal spray and sodium cromoglycate nasal spray in the management of seasonal allergic rhinitis.

The prophylactic use of beclomethasone dipropionate (BDP) aqueous nasal spray was compared with sodium cromoglycate (SCG) nasal spray in the management of seasonal allergic rhinitis. Eighty-six patients with proven grass pollen sensitivity were given either a BDP or SCG nasal spray to use for six weeks during the hay fever season of 1982. Patients were seen prior to the start of treatment, once during and finally after six weeks therapy. Throughout they kept a daily record of symptoms and medication. Assessments of symptom control showed the BDP to be significantly better than SCG (p less than 0.05). Further analyses, in particular of patients with severe hay fever and days with high pollen counts confirmed the superiority of BDP over SCG in controlling symptoms. It was interesting to note that in study the symptom score correlated best with the pollen counts one day earlier. Additional medication requirements were similar in the two groups. Although the patients' assessments were similar for the two treatments, those of the physician indicated the BDP to be more effective than SCG in preventing or alleviating symptoms. The incidence of side effects was low and similar in both treatment groups. The study indicates that the new BDP aqueous nasal spray is effective and well tolerated by patients with seasonal rhinitis.

Administration, Intranasal↗