Functional thyroid follicular adenocarcinoma in a captive mountain lion (Felis concolor).
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Adenocarcinoma↗
Biomedical subjects
F A Kallfelz
Publications and source records attributed to F A Kallfelz.
Severe masseter myonecrosis in a horse.
A 6-year-old Quarter Horse was examined because of acute, severely swollen masseter muscles (palpation of which elicited pain response), exophthalmos, severe chemosis, and protrusion of the third eyelids. Blood selenium and vitamin E concentrations, and results of feed analysis and muscle biopsy supported a diagnosis of nutritional myopathy. The horse was treated and was clinically normal 2 weeks after discharge from the hospital.
Animals↗
Osteochondrosis in fetuses of ewes overfed calcium.
Ewes were fed ad libitum (up to maximum of 2.5 kg/day) a complete feed containing either 1.52% calcium (High Ca) or 0.59% calcium (Normal Ca) on a dry matter basis from day 50 of pregnancy, and the fetuses were removed at 133-135 days. Thyroid C cells, identified by indirect immunofluorescence, were more numerous (P less than 0.001) and plasma levels of 24,25-dihydroxycholecalciferol [24,25(OH)2D] were higher (P less than 0.09) in fetuses of High Ca ewes. These fetuses also had retarded cartilage differentiation in the proximal humeral epiphysis and metaphysis as well as transverse trabeculation in the epiphysis. These entities are two of the hallmarks of osteochondrosis. It was shown that feeding high dietary calcium to pregnant ewes caused osteochondrosis in their fetuses. Hypercalcitoninism and/or an adverse effect of supraphysiological levels of 24,25-dihydroxycholecalciferol may have been contributory to the skeletal abnormalities.
24,25-Dihydroxyvitamin D 3↗
Dietary taurine deficiency and dilated cardiomyopathy in the fox.
Taurine deficiency has been implicated as a potential cause of dilated cardiomyopathy. However, the relationship between taurine and myocardial function is presently unclear. The purpose of this study was to determine whether dilated cardiomyopathy in the fox is associated with dietary taurine deficiency. A total of 68 foxes from farms with a history of death caused by dilated cardiomyopathy and 14 foxes from a farm with no history of dilated cardiomyopathy were studied. Dilated cardiomyopathy was diagnosed by echocardiography in 48% of the foxes from one farm with a positive history and in none of the foxes from the control farm. Foxes less than 9 months of age were more commonly affected than older foxes (p = 0.03). Plasma taurine concentrations were significantly less (p less than 0.01) in foxes that had dilated cardiomyopathy (26.8 +/- 16.4 nmol/ml) than in the control foxes (99.3 +/- 60.2 nmol/ml). A significantly higher (p less than 0.01) incidence of dilated cardiomyopathy was present in foxes with a history of a sibling or offspring that died of dilated cardiomyopathy than in foxes without a family history of cardiac death. In one fox with dilated cardiomyopathy that was tested, the myocardial taurine concentration was lower (1.7 mumol/gm wet weight) than that of control foxes (7.3 +/- 1.6 mumol/gm wet weight). Hepatic cysteinesulfinic acid decarboxylase activity was significantly less (p less than 0.001) in foxes with dilated cardiomyopathy (0.97 +/- 0.2 nmol/mm.mg protein) than in control foxes (2.11 +/- 0.07 nmol CO2/mm.mg protein).(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
Effects of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol in dogs with impaired renal function.
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24,25-Dihydroxyvitamin D 3↗
Functional analysis of ectopic parathyroid activity in cats.
The ability of ectopic parathyroid tissue to support calcium homeostasis was evaluated by measuring serum concentrations of calcium, phosphorus, albumin, magnesium, and parathyroid hormone before and for 12 weeks after bilateral thyroparathyroidectomy in 14 cats. During the immediate postoperative period, significant decrease was observed in serum calcium, magnesium, and parathyroid hormone (PTH) concentrations. Serum PTH concentration remained subnormal and did not significantly increase during the 12-week observation period. Despite persistent hypoparathyroidism, serum calcium and magnesium concentrations gradually increased. Ectopic parathyroid tissue is not capable of maintaining normal serum calcium concentration immediately after thyroparathyroidectomy. Serum calcium concentration gradually normalizes after thyroparathyroidectomy, apparently by means of a PTH-independent mechanism.
Animals↗
An experimental model of chronic renal disease in dogs by infusion of microspheres into the renal arterial circulation.
The feasibility of renal arterial infusion of nonbiodegradable microspheres as a model of chronic renal disease in dogs was evaluated. Resin-coated, styrene-divinyl benzene copolymer microspheres were infused into the kidneys of healthy adult Beagles by direct injections of both renal arteries in a single surgical procedure. Injections of 25-microns diameter microspheres had minimal effect on either the clinical status or serum values of the dogs. Histologic examination revealed the majority of the microspheres lodged within the capillary beds of the glomeruli, and little change to the kidneys. However, injections of 50-microns diameter microspheres caused significant increases in serum concentrations of urea nitrogen and creatinine. Histologically, the larger microspheres obstructed afferent arterioles and small arteries, which caused diffuse glomerular necrosis and nephron damage. With doses ranging from 1 to 3 million microspheres/dog, a correlation between the quantity of microspheres injected and severity of renal damage was observed. The optimal dose for producing a model of moderate renal disease was determined to be 1.8 million microspheres/dog (0.9 million microspheres/kidney). During long-term studies, microsphere-injected dogs fed a moderately restricted protein ration remained relatively azotemic, compared with control dogs on the identical ration. During the 5-month postsurgical period, the serum urea nitrogen concentration averaged 18.41 +/- 1.59 mg/dl (mean +/- SE) for the microsphere-injected dogs vs 9.31 +/- 0.38 for the control dogs (P less than 0.001). Similarly, the mean serum creatinine value was significantly higher (P = 0.020) for the microsphere-injected dogs, compared with the controls (1.23 +/- 0.12 mg/dl vs 0.94 +/- 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
Factors associated with the development of equine degenerative myeloencephalopathy.
A case-control study was done to identify factors associated with the development of equine degenerative myeloencephalopathy (EDM). Questionnaires were mailed to the owners of 146 horses admitted to the New York State College of Veterinary Medicine between November 1978 and June 1987 and diagnosed as having EDM by histologic examination. Questionnaires also were sent to owners of 402 clinically normal horses admitted to the college during the same period. Data were compared between the EDM-affected and control groups (56 and 179 questionnaires returned, respectively). Risk factors identified included the use of insecticide applied to foals, exposure of foals to wood preservatives, and foals frequently spending time on dirt lots while outside. Foals spending time outside on green pastures was a protective factor. Foals from dams that had had an EDM-affected foal were at higher risk of developing EDM than were foals from other dams.
Age Factors↗
Evaluation and use of pet foods: general considerations in using pet foods for adult maintenance.
Questions regarding pet animal nutrition are probably among the most frequent queries encountered by companion animal veterinarians. Given the plethora of pet food products available and the amount of advertising used to promote them, it is not surprising that pet owners have concerns as to what they should feed their pets. This "practical" review of pet foods and feeding is designed to assist veterinarians in making nutritional recommendations to their clients, with respect to feeding normal adult pets at maintenance.
Animal Feed↗
Overnutrition: an epidemic problem in pet animal practice?
This review demonstrates that manufactured pet foods contain more than adequate levels of all the essential nutrients needed by normal dogs and cats. Under normal circumstances, therefore, it is completely unnecessary to supplement the rations of these animals with protein, energy, fatty acids, vitamins, or minerals. We have tried to show that, in addition to being unnecessary, supplementation of the rations of normal animals may be quite dangerous, leading to serious--indeed, sometimes fatal--clinical consequences. Pet food manufacturers have responded to newer information regarding increased requirements for specific nutrients such as taurine and potassium. Thus, supplements of these nutrients, as well, are unnecessary in the absence of specific clinical indications. As practitioners, we should be wary of beneficial effects claimed for nutritional supplements. Anecdotal comments, in particular, should be discounted completely. Objective data, including statistical evaluation demonstrating efficacy, should be demanded before accepting claims for such products. Finally, the use of nutritional supplements should be restricted to those cases in which specific clinical problems dictate their use.
Animal Feed↗
Serum vitamin E and blood glutathione peroxidase values of horses with degenerative myeloencephalopathy.
Serum vitamin E and blood glutathione peroxidase values were determined in 40 horses with a histologically confirmed diagnosis of degenerative myeloencephalopathy and in 49 age-matched control horses with normal neurologic function. Significant differences were not detected in serum vitamin E or blood glutathione peroxidase values between horses affected with degenerative myeloencephalopathy and control horses. These findings fail to support a reported role of vitamin E deficiency as a cause of equine degenerative myeloencephalopathy.
Animals↗
Cerebellar infarction caused by arterial thrombosis in a dog.
A cerebellar infarction was found to be caused by a vascular thrombosis in a dog. The cause of the thrombosis was not determined. The dog had signs of a central vestibular disturbance. Scintigraphic imaging of the brain revealed evidence of increased uptake of the radionucleotide within the cranial vault. Analysis of CSF revealed albuminocytologic dissociation. Histologically, there was severe, locally extensive, well-demarcated hemorrhagic necrosis within the left cerebellar hemisphere. A mural thrombus was evident within a large meningeal artery. Although thrombosis of cerebrospinal vessels is rare in the dog, it should be considered in the differential diagnosis as a cause of acute CNS dysfunction.
Animals↗
Influence of magnesium, water, and sodium chloride on urolithiasis in veal calves.
Forty veal calves were fed milk replacers containing differing concentrations of Mg in a 16-w study. The concentrations were .1% (basal), .3%, .6% Mg, and .6% Mg plus 2% NaCl. The four groups were further subdivided into two groups fed reconstituted milk replacer at 14 or 17.9% DM. Weight gain was greater at the two lower concentrations of Mg. Calves fed .6% Mg or .6% Mg plus NaCl excreted significantly more Mg than calves fed .1 or .3% magnesium. The low water group (17.9% DM) excreted a more concentrated urine relative to Mg, Ca, and P than did the high water group (14% DM). No urethral obstructions were observed. Seventy percent of calves at .6% Mg and 30% of calves at .6% Mg plus NaCl had stones in their kidneys consisting primarily of calcium apatite and secondarily of struvite. Added NaCl reduced kidney and bladder calculi formation. When high amounts of water were fed, added NaCl prevented calculi formation completely. All calves fed the NRC level of .1% Mg performed normally.
Animals↗
Reproductive patterns in cyclic and pregnant thyroidectomized mares.
Three Quarter-horse mares were thyroidectomized at about 1.5 years of age. Three similar intact mares served as controls. The study continued through two breeding seasons. The thyroidectomized mares were lethargic, rear limbs were oedematous and hair coats were coarse. They displayed a tranquil oestrous behaviour when exposed to a stallion and were only mildly antagonistic when not in oestrus. Length of oestrous cycles varied but most often they were 19-24 days long. Duration of oestrus (mean +/- s.e.m.) for the control and thyroidectomized mares was 12.9 +/- 2.9 and 11.7 +/- 2.2 days respectively (P greater than 0.05). The peak of LH during oestrus was as high as 60 ng/ml blood serum with no difference between the two groups. Peak progestagen on Day 7 after ovulation for controls was 9.0 +/- 1.6 ng/ml and was not different (P greater than 0.05) from the peak of 6.3 +/- 1.7 ng/ml for thyroidectomized mares on Day 8. Pregnancy was achieved in both groups of mares, including the use of semen from a thyroidectomized stallion. Thyroxine was detectable in one pregnant thyroidectomized mare during the last two-thirds of pregnancy only.
Animals↗
Dietary magnesium and urolithiasis in growing calves.
The effect of high levels of dietary magnesium (1.4%) alone or in combination with elevated calcium (1.8%) or phosphorus (1.6%) on growth and health of male calves was evaluated during a nine week feeding trial after weaning. Twenty calves were randomly divided into 4 feeding groups consisting of controls, high magnesium, high magnesium and calcium or high magnesium and phosphorus. Elevated dietary minerals caused decreased feed intake and growth rate. Blood urea nitrogen and serum creatinine levels were greatly elevated in calves fed high magnesium or magnesium and phosphorus and serum urea nitrogen was moderately elevated in calves fed high magnesium and calcium. These elevations suggested the occurrence of renal damage as a result of microcrystalline obstruction of renal tubules. Serum magnesium levels were three times normal in calves fed high magnesium or magnesium and phosphorus, but only twice normal in calves fed high magnesium and calcium. High dietary magnesium resulted in a significant depression in blood calcium level. This effect was somewhat overcome by additional dietary calcium Three calves fed the high magnesium diet and two calves fed the high magnesium and phosphorus diet developed urinary tract obstruction. The chemical composition of uroliths recovered from these calves was calcium apatite. Elevated dietary magnesium has been shown to be a cause of urolithiasis in growing male calves. Additional dietary calcium, but not phosphorus, appears to protect calves against urolithiasis induced by elevated dietary magnesium.
Animals↗
External monitoring of 203Hg-labelled Dirofilaria immitis microfilariae in mice and dogs.
Microfilariae of Dirofilaria immitis were labelled with 203Hg2+ in vitro and injected into irradiated mice and Beagle dogs. With irradiated mice it was possible to demonstrate microfilariae present in the blood and to detect 203Hg by external counting as long as 28 days after dosing. The 203Hg2+ label had a half-time of 4-5 days; the amount of stable mercury in the labelling medium strongly influenced the survival of microfilariae in vivo. In dogs, external counting showed the lungs to be a major location of the microfilariae soon after reinjection into the host. Evidence was obtained that labelled microfilariae can circulate; however, the detection of dispersed microfilariae is difficult because of the relative insensitivity of the detecting system. For radiomercury the accumulation of the inorganic form in the liver and kidneys limits the long-term usefulness of 203Hg2+ as a label if the organism being studied also accumulates in these organs.
Animals↗
Scintigraphic diagnosis of primary hepatocellular carcinoma in the woodchuck (Marmota monax).
Hepatic imaging with 99mTc-sulfur colloid was used to diagnose primary hepatocellular carcinoma (PHC) in woodchucks infected with woodchuck hepatitis virus (WHV). Based on imaging results, 6 of 12 WHV-infected woodchucks had space-occupying hepatic lesions, and all 6 had PHC. Of the remaining woodchucks, 2 did not have PHC, 2 had discrete tumors (less than 1 cm diameter), 1 had miliary small tumors, and 1 had tumors located near the great vessels. Hepatic imaging was a valuable technique for diagnosis of PHC in WHV-infected woodchucks.
Animals↗
Familial nonspherocytic hemolytic anemia in poodles.
Nonspherocytic hemolytic anemia, characterized by marked reticulocytosis, hepatosplenomegaly, hemosiderosis of reticuloendothelial organs and bone marrow myelofibrosis, and osteosclerosis, was diagnosed in 5 related Poodles. The unremitting anemia was clinically evident by 1 year of age, and was fatal as early as 3 years of age. Despite intense diagnostic endeavors including RBC fragility studies, RBC enzyme assays, and hemoglobin electrophoresis, the cause of this nonspherocytic hemolytic anemia remains to be determined.
Anemia, Hemolytic, Congenital↗