Biomedical subjects

F A MATHEWSON

Publications and source records attributed to F A MATHEWSON.

11 recordsLinked to original sources

PubMed1965

THE UNIVERSITY OF MANITOBA FOLLOW-UP STUDY: A PROSPECTIVE INVESTIGATION OF CARDIOVASCULAR DISEASE. II. BUILD, BLOOD PRESSURE AND ELECTROCARDIOGRAPHIC FACTORS POSSIBLY ASSOCIATED WITH THE DEVELOPMENT OF CORONARY HEART DISEASE.

The relationship of selected physical and electrocardiographic factors to the occurrence of coronary heart disease was examined in a cohort of 3983 healthy North American males followed up for 15 years. Variations in build or mean heart rate were not found to be related to the occurrence of coronary heart disease. The risk of coronary heart disease rose progressively as blood pressure increased. With readings of 160/95 mm. Hg or higher the risk was 1.77 times that of the population as a whole. Non-specific S-T and/or T wave changes in the electrocardiogram were associated with three times the risk of developing coronary heart disease. Individuals with the combination of a blood pressure of 160/95 mm. Hg and nonspecific T wave changes exhibited an augmented susceptibility to coronary heart disease, the risk being four times that of the whole population.

Blood Pressure↗

PubMed1965

THE UNIVERISTY OF MANITOBA FOLLOW-UP STUDY: A PROSPECTIVE INVESTIGATION OF CARDIOVASCULAR DISEASE. I. GENERAL DESCRIPTION--MORTALITY AND INCIDENCE OF CORONARY HEART DISEASE.

A prospective study of cardiovascular disease was initiated in 1946 whereby 3983 healthy North American males, 91% under age 40, were subjected to periodic electrocardiograms and medical examinations between 1948 and 1963. The health of all but five of the 3773 survivors was known in 1963. There were 210 deaths: aircraft accidents accounted for 45%, cardiovascular disease 20%, cancer 11% and other causes 23%. The aggregate mortality closely resembled that of the Canadian Life Table 1955-57 (Male). Extra deaths were observed under age 40 owing to a high frequency of flying accidents. At older ages the mortality was lower than expected because congenital and chronic diseases were excluded at entry. One hundred and forty-three developed coronary heart disease. The case fatality rate was 31%. The incidence rate for coronary heart disease rose progressively from 0.277 per thousand per year for ages 25-34 to 26.5 at ages 60-69.

Accidents↗

PubMed1964