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Biomedical subjects

F A Miller

Publications and source records attributed to F A Miller.

108 records · Page 6Linked to original sources
PubMed1968

Antiviral activity of carbobenzosy di- and tripeptides on measles virus.

A series of simple carbobenzoxy peptides showed high and consistent antiviral chemotherapeutic activity in cell culture. In general, greatest activity was found against the measles-distemper or herpesvirus groups, or both, but various representatives of the series had quantitatively and qualitatively different antiviral activities. Several of the compounds, showing the highest antimeasles activity, were investigated extensively. In human cell culture plaque assays, these compounds were active against measles virus at levels of from 15 to 500 mug/ml. At single doses of about 250 to 500 mg/kg, orally in three animal species, significant serum levels of drugs were detected in virus cell culture assays. The mode of action appeared to be therapeutic, as an effect was seen in cell systems infected for at least 24 hr before treatment.

Adenoviridae↗
PubMed1967

Inhibition of B virus in cell culture by 5-iodo-2'-deoxyuridine.

The antimetabolite 5-iodo 2'-deoxyuridine (IDU) interferes with B virus replication in monolayers of cynomolgous monkey kidney, KB and HEp 2 cells. To determine the effect of this clinically active nucleoside in laboratory antiviral screening systems, several methods were compared. Most of the methods used were capable of detecting the activity of IDU at low levels.

Antiviral Agents↗
PubMedDate not supplied

Two-dimensional and Doppler echocardiographic assessment of infiltrative cardiomyopathy.

Infiltrative cardiomyopathies can be divided by disease into infiltrative and storage disorders that show an increase in ventricular wall thickness caused by infiltration of pathologic substances between cells, as with amyloid and sarcoid, or deposition within cells, as with iron, glycogen, and lipid. Two-dimensional and Doppler echocardiography are powerful noninvasive tools in the assessment of the anatomic and functional characteristics of these disorders. With cardiac amyloidosis as the prototype, the constellation of findings of a small or normal left ventricular cavity size; markedly increased thickness of the ventricular walls, associated with a highly abnormal texture; and biatrial enlargement make up its characteristic appearance. However, there is a wide spectrum of abnormalities in this disorder, depending on the stage and duration of heart involvement. Doppler assessment of diastolic function is frequently abnormal in cardiac amyloidosis. Cardiac sarcoidosis usually is evident by a dilated segmental cardiomyopathy with regional wall abnormalities. Similarly, hemochromatosis appears as a dilated cardiomyopathy with normal wall thickness. The echocardiographic appearance of glycogen and glycolipid storage diseases is similar to cardiac amyloidosis, and biochemical analysis may be necessary for differentiation. Thus echocardiography is an important tool in the characterization of infiltrative cardiomyopathies.

Amyloidosis↗
PubMedDate not supplied

Aortic dissection: review of value and limitations of two-dimensional echocardiography in a six-year experience.

The utility of transthoracic two-dimensional echocardiography in patients with aortic dissection was assessed by retrospective analysis in 67 patients: 31 patients with DeBakey type I, 21 patients with type II, 10 patients with type III, and five patients with false-positive diagnoses. Aortic dissection was correctly identified by two-dimensional echocardiography in 49 patients; 13 had false-negative diagnoses. Therefore the sensitivity was 79%, and the positive predictive accuracy was 91%. Transthoracic two-dimensional echocardiography is a reasonable screening technique for diagnosis of aortic dissection.

Acute Disease↗
PubMedDate not supplied

Frequency of Doppler measurable pulmonary artery pressures.

The current literature suggests that right-sided heart pressures can be obtained noninvasively in approximately 60% of patients. We hypothesized that with a focused echocardiographic Doppler examination, measurable tricuspid or pulmonary valve regurgitation suitable for measuring pressures could be obtained in a higher percentage of patients. The study group consisted of 200 consecutive patients undergoing echocardiographic and Doppler hemodynamic evaluation. All patients were first examined by an ultrasonographer instructed to attempt to record tricuspid and pulmonary regurgitant velocities. After this examination, a designated cardiologist performed a focused examination with the intent of improving the signal quality and increasing the number of measurable signals for evaluation. Tricuspid regurgitation of measurable quality was recorded in 147 (73.5%) of 200 patients by the ultrasonographer; this result was improved to 172 patients (86%) by the designated cardiologist. Pulmonary regurgitation was obtainable in 147 (95%) of 154 patients and was of measurable quality in 137 (89%). When results of tricuspid and pulmonary regurgitation were combined, a quantifiable signal was obtained in 194 (97%) of 200 consecutive unselected patients. This study demonstrates that a well-trained ultrasonographer or echocardiologist can obtain right-sided pressures in at least 95% of all unselected cardiovascular patients.

Adolescent↗
PubMedDate not supplied

Leadership strategies for professional development.

This paper will identify those leadership strategies necessary for professional development. It will begin with a brief review of the concept of leadership and the components associated with effective leadership. This will be followed by a short discussion of the role of leadership behaviors in professional development. Finally, the major content of this paper will address professional development and the strategies needed to develop the professional self.

Career Mobility↗