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Biomedical subjects

F A Popp

Publications and source records attributed to F A Popp.

At least 19 recordsLinked to original sources
PubMed2003

Biophoton emission of human body.

For the first time systematic measurements of the "ultraweak" photon emission of the human body (biophotons) have been performed by means of a photon detector device set up in darkness. About 200 persons have been investigated. In a particular case one person has been examined daily over several months. It turned out that this biophoton emission reflects, (i) the left-right symmetry of the human body; (ii) biological rhythms such as 14 days, 1 month, 3 months and 9 months; (iii) disease in terms of broken symmetry between left and right side; and (iv) light channels in the body, which regulate energy and information transfer between different parts. The results show that besides a deeper understanding of health, disease and body field, this method provides a new powerful tool of non-invasive medical diagnosis in terms of basic regulatory functions of the body.

Humans↗
PubMed2001

Ultraweak photon emission in assessing bone growth factor efficiency using fibroblastic differentiation.

Photons participate in many atomic and molecular interactions and changes. Recent biophysical research has shown the induction of ultraweak photons in biological tissue. It is now established that plants, animal and human cells emit a very weak radiation which can be readily detected with an appropriate photomultiplier system. Although the emission is extremely low in mammalian cells, it can be efficiently induced by ultraviolet light. In our studies, we used the differentiation system of human skin fibroblasts from a patient with Xeroderma Pigmentosum of complementation group A in order to test the growth stimulation efficiency of various bone growth factors at concentrations as low as 5 ng/ml of cell culture medium. In additional experiments, the cells were irradiated with a moderate fluence of ultraviolet A. The different batches of growth factors showed various proliferation of skin fibroblasts in culture which could be correlated with the ultraweak photon emission. The growth factors reduced the acceleration of the fibroblast differentiation induced by mitomycin C by a factor of 10-30%. In view that fibroblasts play an essential role in skin aging and wound healing, the fibroblast differentiation system is a very useful tool in order to elucidate the efficacy of growth factors.

Adolescent↗
PubMed1994

Log-normal distribution of physiological parameters and the coherence of biological systems.

The well-known fact that biological parameters, randomly selected, are distributed according to log-normal frequency curves instead of normal ones, has been traced back to a 'multiplicative Gestaltungs-principle of nature'. A further analysis shows that the basis of this principle can be assigned to the optimization of connections in a network of circuit elements, or, even more profoundly, to the formation of coherent states in living systems. The diagnosis of patients based on physiological frequency distributions provides a new powerful tool of understanding sickness in terms of deviations from a basic regulation principle.

Animals↗
PubMed1993

Light-induced photon emission by mammalian cells.

In this work, the light-induced photon emission (IPE) by suspensions of mammalian cells was examined. IPE is extremely low and for detection in a single photon counting device with a cooled EMI 9558QB photomultiplier tube was used. The mammalian cells in this study were from different tissues and different mammalian species including cat, Chinese hamster, cow, dog, human, monkey, mouse and rat. The IPE was detected in all mammalian cells tested, but was different for the various cell types, ranging from 4 to 100 photons per 10(4) cells. Although our data agree with previous studies in that the IPE of non-fibroblastic normal cells is distinct from that of malignant cells our results reveal that cells of fibroblastic origin show the highest IPE values.

3T3 Cells↗
PubMed1992

Nonlinear response of biophoton emission to external perturbations.

By considering an exciplex system consisting of collective molecules in interaction with both the 'pumping' fields and the biophoton fields, the two-level exciplex model and the three-level exciplex model are presented. They are useful for the investigation of the quasi-stationary behaviour of biophoton emission, and biophoton emission as a dynamic process in the presence of external perturbations. Our theoretical results predict a series of nonlinear effects, such as chaos, fractal behaviour, and non-equilibrium phase transition. These effects characterize the coherence nature of living systems. In our approaches, there are two important quantities f and x, which can be used to mark the working points of the two-level and three-level exciplex systems. All the influences of external perturbations on the exciplex systems, e.g. change of temperature, the addition of agents, exposure to light, etc., can be interpreted as shifts of the working points of the systems, leading to a diversity of nonlinear response of biophoton emission. In addition, the agreements of the theoretical results and the corresponding experimental observations on biophoton emission from biological systems in the presence of external perturbations are demonstrated.

Mathematics↗
PubMed1988

Physical aspects of biophotons.

By comparing the theoretically expected results of photon emission from a chaotic (thermal) field and those of an ordered (fully coherent) field with the actual experimental data, one finds ample indications for the hypothesis that 'biophotons' originate from a coherent field occurring within living tissues. A direct proof may be seen in the hyperbolic relaxation dynamics of spectral delayed luminescence under ergodic conditions. A possible mechanism has to be founded on Einstein's balance equation and, under stationary conditions, on energy conservation including a photochemical potential. It is shown that the considered equations deliver, besides the thermal equilibrium, a conditionally stable region far away from equilibrium, which can help to describe both 'biophoton emission' and biological regulation.

Animals↗
PubMed1988

Light-stimulated ultraweak photon reemission of human amnion cells and Wish cells.

Photon reemission in the ultraweak intensity range that is observed after irradiation of cell suspensions with light, reveals characteristic differences between normal human amnion cells and transformed Wish cells from the same parental tissue. The reemission kinetics, approximated best by a hyperbolical process, were studied as a function of cell density, showing that: malignant Wish cells have a photon storage capacity that is not improved by increasing the cell density; and that normal amnion cells exhibit a photon storage capacity that strongly increases with increasing cell density. The interpretation of this effect and the nature of the emitter are discussed.

Amnion↗
PubMed1984

Biophoton emission. New evidence for coherence and DNA as source.

The phenomenon of ultraweak photon emission from living systems was further investigated in order to elucidate the physical properties of this radiation and its possible source. We obtained evidence that the light has a high degree of coherence because of (1) its photon count statistics, (2) its spectral distribution, (3) its decay behavior after exposure to light illumination, and (4) its transparency through optically thick materials. Moreover, DNA is apparently at least an important source, since conformational changes induced with ethidium bromide in vivo are clearly reflected by changes of the photon emission of cells. The physical properties of the radiation are described, taking DNA as an exciplex laser system, where a stable state can be reached far from thermal equilibrium at threshold.

DNA↗
PubMed1983

A physical (electromagnetic) model of differentiation. 2. Applications and examples.

The electromagnetic model of cell differentiation originated by Nagl and Popp (1983) was applied to two biological events, chromatin condensation and photoperiodicity (oscillations). Some experiments are suggested, which may help to refute or verify, respectively, the role of ultraweak photon emission in differentiation and the control of gene activity.

Cell Differentiation↗
PubMed1983

A physical (electromagnetic) model of differentiation. 1. Basic considerations.

There are a number of biological phenomena and events that cannot yet be adequately described, such as cell growth and differentiation, which may be controlled by physical factors. Fröhlich (1980) has discussed the principles of dissipative structures as applied to electromagnetic interactions in relation to basic couplings in biological systems. Recently, increasing evidence of photon storage and ultraweak photon emission from living systems, particularly from DNA, has suggested the concept of an electromagnetic model of differentiation, based on the known quantum optical properties of nucleic acids. This model has the advantage over all ideas so far published, that it is (1) simple; (2) universally applicable to events in living matter, because it is consistent with both the quantum mechanical and the thermodynamic properties on the one hand, and the known biological and biochemical data and phenomena at the other hand; (3) it not only describes the phenomena and events in terms of pure mathematical parameters, but it can also explain them; and (4) it escapes the difficulty of finding basic control mechanisms, which themselves do not need a regulator, ad infinitum.

Animals↗
PubMed1977

Model studies in tumor incidence.

Two models of tumor incidence predicting the latency period as a function of the applied dose of a carcinogenic compound yield the same relationship as it has been empirically stated by Bryan and Shimkin (1,2). One model is based on a single-cell damage, the other one on a disturbtion of proliferation control within the cell population. The observed latency periods compared to the predicted values show that the tommunication model is a better basis for understanding chemical carcinogenesis than the single cell incidence.

Benz(a)Anthracenes↗
PubMed1977

A very significant correlation between carcinogenic activity of polycyclic hydrocarbons and certain properties of their transition states in the range of the lowest triplet states of the DNA.

A very significant correlation between carcinogenic power of polycyclic aromatic hydrocarbons and their probability of photoinduced double resonance transitions in the UV-range of about 3 to 3.5 eV is shown. The resonance can be interpreted in terms of the lowest triplet state energy of thymine at 3.25 eV and the energy difference between the triplet states of A--T and G--C base pairs. The correlation has been predicted from a hypothesis which describes cell communication by photon interaction within a cell population.

Carcinogens↗
PubMed1975

[The dose-volume factor in radiotherapy. Significance of the focal or tumor volume for the evaluation of radiotherapeutic effect].

The absorbed energy dose, in dependence on the irradiated tissue volume or tumor volume (dose-volume-relations) has great significance for the valuation of radiation injuries and of the prognosis of the disease. The present paper includes an analysis, formal demonstrations and interpretation of these relations. Clinical observations and radiobiological experiments in literature were the basis of the present investigation. The assessment is kept simple, the models derived from it interprete well the clinical findings. Through these models, radiobiological findings and clinical experimental principles are connected. This results in a clear conception of the future development of irradiation planning, and the application technique of radiation. The range of validity of the cited models includes the treated volumes usual in radiotherapy. An extrapolation to the cellulary area or to the whole body may only be made with great reservations.

Humans↗
PubMed1975

[Optimation of irradiation planning in deep therapy. Outline of the chance of survival of tumor patients].

Simple model conceptions are used for the demonstration of the chance of survival of tumor patients. The systematic judgement of therapy is possible after the adaptation to known survival curves for patients in different stages. The ascertainment of the tumor duplication period for primary tumor and--on principle--also for metastases, permits of conclusions on the recuperative capacity and radioresistance of the exposed normal tissue and of the tumor. It was seen that the values found can lie in the range of the data known from radiobiology. Vice versa, it is possible in principle by means of derived relation to optimate dose distribution, fractionation and total dose of the radiotherapy. Moreover, the systematic analysis of the known survival curves of tumor patients within the frame of model conception allows of the expectation that also influences of therapy on the tumor duplication time, and possibly the dissemination capacity of the tumor, can be analysed. These values reflect the tumor-host-relations and seem to be of decisive significance for future successful concepts of therapy.

Growth↗