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Biomedical subjects

F A Rice

Publications and source records attributed to F A Rice.

35 records · Page 2Linked to original sources
PubMed1970

Isolation of leucogenenol from bovine and human liver.

A compound has been isolated from both bovine and human liver that on intravenous or intraperitoneal injection into animals induces in 4-12h an increase in the number of peripheral neutrophils, and in 12-24h an increase in the number of peripheral lymphocytes. At 24h after injection there is also a two- to three-fold increase in the relative number of myeloblasts in the bone marrow. The procedure for isolation and the physical and chemical properties identify the compound as leucogenenol, isolated from the metabolic products of Penicillium gilmanii by Rice (1966).

Animals↗
PubMed1967

Chemical determination of leucogenenol and its production by Penicillium gilmanii.

A method for the quantitative determination of leucogenenol, a leucocytosis-inducing compound produced by Penicillium gilmanii, has been developed. The formation of leucogenenol in P. gilmanii and its diffusion into the culture fluid has been followed over a period of 12 weeks. The highest concentration of leucogenenol was found in the mycelium of rapidly growing cultures. The greatest concentration occurred in the culture fluid, however, after cessation of rapid growth. The concentration of leucogenenol in the mycelium of cultures over 4 weeks old fluctuated widely. This fluctuation was apparently due to the formation and rapid growth of daughter colonies.

Culture Media↗