Biomedical subjects

F A Scialabba

Publications and source records attributed to F A Scialabba.

6 recordsLinked to original sources

PubMed1990

Synovial cell sarcoma.

Synovial cell sarcoma frequently presents as a painful periarticular mass in the lower extremity of a young male patient. The mass may appear encapsulated and is calcified in approximately 50 percent of cases. Surgery is the mainstay of therapy, with radical resection often necessary to prevent local recurrence. The maximal five-year survival rate is 40 percent. Survival is associated with small lesions, absence of metastases and histologically low-grade lesions in younger patients.

Adolescent↗

PubMed1990

Lymphoma presenting as a periorbital tumor.

Lymphoma is a common tumor of the periorbital region. Facial radiographs may show a soft tissue mass. Radiologic differential diagnosis of orbital masses is difficult. Computed tomographic scanning with intravenous contrast medium is useful in diagnosing and staging neoplasms in this area.

Diagnosis, Differential↗

PubMed1990

Solitary pulmonary metastasis from melanoma.

Malignant melanoma often presents with multiple-organ involvement. Pulmonary metastases are present in more than 50 percent of patients with a diagnosis of melanoma at autopsy. Metastases to the lung may be solitary or multiple. Computed tomographic scanning is the most sensitive radiologic method for detecting these pulmonary lesions.

Aged↗

PubMed1990

Saccular aneurysms of the thoracic aorta.

In the evaluation of thoracic masses adjacent to vascular structures, aneurysms must be considered as a possible etiology. Particular consideration must be given to this possibility before percutaneous biopsy is performed. While contrast-enhanced computed tomography or magnetic resonance imaging is usually sufficient for making the diagnosis, angiography remains the gold standard for characterization and preoperative planning.

Aged↗

PubMed1990

Transient osteoporosis of the hip.

This uncommon entity typically presents in young to middle-aged patients. The clinical features are progressive pain and a limp with no history of trauma. Bone density in the affected femur is progressively affected. The process is self-limited, with gradual improvement of symptoms and bony mineralization within several months.

Adult↗

PubMed1987

Stimulation of substantia nigra pars reticulata enhances dentate granule cell excitability.

We studied the effects of electrical and chemical stimulation of the substantia nigra (SN) on the dentate granule cell (DGC) response to perforant path stimulation. Studies were carried out in both pentobarbital anesthetized and awake freely moving rats. Chemical stimulation was achieved by microinjection of N-methyl-D,L-aspartate (NMDA), an excitatory amino acid. Electrical preconditioning stimulation applied to the area of the SN, but not dorsal to SN, increased the excitability of DGCs. Intracerebral microinjection of NMDA into the contralateral SN pars reticulata (SNR), but not into SN pars compacta or cerebral peduncle, also produced a marked and reversible enhancement of DGC excitability. In both instances, the increased DGC excitability consisted of increased amplitude of the perforant path evoked population spike without change in the slope of the population excitatory postsynaptic potential (pEPSP). We interpret the data to indicate that increasing the output of the SNR increases the excitability of the DGCs, a limbic neuronal population regulating information transfer through hippocampal pathways. Together with our previous finding that decreasing the output of SNR suppressed limbic seizures, these data demonstrate that the SNR exerts a powerful influence on limbic system excitability. Delineating the anatomic pathway mediating this influence could provide valuable insight into the mechanisms underlying basal ganglia-limbic interactions in both physiologic and pathologic conditions.

Action Potentials↗