A comparison of two computer programs for searching the medical literature.
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Education, Medical↗
Biomedical subjects
F A Simon
Publications and source records attributed to F A Simon.
Leiomyomas in pregnancy.
Although the growth of uterine leiomyomas is influenced by estrogens, growth during pregnancy has been documented in only a small fraction of cases. Degeneration or torsion of a pedunculated leiomyoma can cause pain. The cesarean section rate is not increased. Pregnant patients with leiomyomas should be followed with serial ultrasound to document the location, size and growth of the tumors, as well as fetal growth. The majority of pregnancies in women with leiomyomas have good outcomes.
Adult↗
Immunologic and biologic evaluation of insulin degradation following prolonged storage in plastic syringes.
Insulin potency during storage in plastic disposable syringes for short periods of time is a concern of diabetics as well as syringe manufacturers. Previous studies have indicated that leaching of organic materials from rubber gaskets may have cytotoxic effects. The purpose of this study was to evaluate the immunologic and radioreceptor degradation of insulin storage in commercial plastic syringes. Insulin syringes were filled with insulin and stored at 4 degrees C for 2 weeks. Immunologic potency was assessed by radioimmunoassay while biologic potency was evaluated by binding to hepatic insulin receptors. Recoverable insulin was measured on days 1, 3, 7, and 14 and compared with highly purified porcine insulin. Insulin content of samples stored in all three plastic syringes showed no statistically significant (p less than 0.05) loss of immunologic or biologic potency for 2 weeks compared with stock controls. Lente insulin gave more variability in storage in the radioimmunoassay, possibly due to settling, and was less effective in displacing labeled insulin in the radioreceptor assay. We conclude that premeasured insulin may safely be stored in plastic disposable syringes under selected conditions, especially in blind and handicapped diabetic patients, for 2 weeks.
Drug Stability↗
Wilms tumor and pigmented nevi.
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Child, Preschool↗
Reevaluation of neonatal Hemophilus influenzae infections.
Hemophilus influenzae infections are increasing in frequency in the general population. As a result this organism must be considered an etiologic agent of disease in the neonate. Proper culture technics must be routinely employed to isolate this fastidious organism, and appropriate antimicrobial therapy must be instituted in infants suspected of having sepsis or meningitis. Three cases of H influenzae infection occurring in neonates are presented.
Abscess↗
Acute yellow phosphorus poisoning. "Smoking stool syndrome".
Three cases of acute phosphorus poisoning are reported. The source of this poison was a rodenticide, which may be in more common use presently because of the increasing resistance of rodents to warfarin derivatives. The safest method of managing poisoning from this highly toxic substance is prevention. Two of the patients had a history of previous medicine overdose.
Acute Disease↗
Evaluation of computer case simulations for teaching clinical pathology to second-year medical students.
A computer-assisted learning program for teaching clinical pathology to second year medical students has been developed and evaluated. These programs are designed to be used as supplements to formal lectures, laboratory exercises, and small group discussions. Students are given case histories and asked to select differential diagnoses, order and interpret laboratory and diagnostic tests, and make final diagnostic conclusions. In some cases, laboratory monitoring of treatment, e.g., drug therapy, is emphasized. The performance of the student is objectively evaluated during each stage. In addition, the amount spent for each workup is recorded with penalties given for excess or inappropriate test ordering. Separate evaluations are performed to assess the effectiveness of these programs as an alternative teaching format to (1) formal lectures and reading assignments, and (2) faculty-directed small group discussions. It is concluded that the computer-assisted learning method is equivalent to lectures and group discussions and is a format that is well accepted by students.
Computer-Assisted Instruction↗