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Biomedical subjects

F A Spengel

Publications and source records attributed to F A Spengel.

60 records · Page 4Linked to original sources
PubMed1981

Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo.

The role of low density lipoprotein (LDL) receptors in the pathogenesis of hereditary and acquired forms of hypercholesterolemia has been investigated in vivo by simultaneously determining total and receptor-independent LDL catabolism with 125I-labeled LDL and 131I-labeled LDL coupled with cyclohexanedione. Receptor-mediated catabolism of LDL, determined as the difference between the turnover of 125I and 131I, was found to be virtually absent in two homozygotes with familial hypercholesterolemia and markedly reduced in a hypothyroid patient. Treatment of the latter with L-thyroxine markedly stimulated receptor-mediated catabolism and reduced LDL levels as did cholestyramine administration in a control subject. Reduction of LDL levels by plasma exchange in a control subject and homozygote had no such effect. These results demonstrate the existence of an intrinsic and almost total defect of receptor-mediated LDL catabolism in homozygous familial hypercholesterolemia and demontrate an analogous but reversible abnormality in hypothyroidism.

Biological Transport↗
PubMedDate not supplied

Late thromboembolic complication from a Palmaz stent in the common iliac artery.

A 56-year-old smoker presented with rest pain in his left leg and hyperfibrinogenemia. He was found to have a high-grade stenosing thrombus in a Palmaz stent which had been placed 4 years ago across a stenosing ulcerating plaque in the left common iliac artery. Systemic thrombolysis was successful but the patient refused long-term anticoagulation. He presented 2 months later with recurrent stent thrombosis and an embolus to the tibioperoneal trunk. Systemic lysis was successfully performed for the stent reobstruction but the distal embolic occlusion responded neither to systemic nor to local thrombolysis. This case suggests that patients with vascular stents and hyperfibrinogenemia and/or nicotine abuse should be considered candidates for long-term anticoagulation.

Blood Coagulation Disorders↗
PubMedDate not supplied

[The value of Duplex sonography in the diagnosis of deep leg and pelvic vein thrombosis].

50 cases, in which phlebography was indicated by clinical symptoms of deep venous thrombosis, were examined by duplex-sonography. In comparison with the phlebographic findings, duplex-sonography was 100% sensitive in detecting thrombosis of the popliteal, femoral and iliac veins and 89% respectively 95% and 100% specific. A sonographic performance of the calf veins was only possible in 44%, the sensitivity in these cases was 92%, specificity 50%. Thus, the non-invasive duplex-sonography is a very appropriate method to diagnose thrombosis of the popliteal region and proximal. For proving or excluding thrombosis of the calf veins phlebography remains necessary.

Adolescent↗
PubMedDate not supplied

[A patient with cystic adventitia degeneration and entrapment syndrome of the popliteal artery].

Adventitial cystic disease and entrapment syndromes of the popliteal artery are rare causes of ischemia in the lower leg in younger patients without cardiovascular risk factors. The 38-year-old male patient described in this case report showed both types of these rare abnormalities in the same vessel, both usually requiring surgical revision even in causing only few symptoms.

Adult↗
PubMedDate not supplied

[Diagnosis of symptomatic plaque in the carotid arteries of patients with neurologic ischemia symptoms].

We compared the neurological symptoms and the results of Duplex-scan (ATL Marc 600 and Ultramarc 4 Duplex Scanner, Advanced Technology Laboratories, Inc., Bothell, WA) examinations of the carotid arteries in 123 patients with transitory or persistent neurological deficit without hemodynamically relevant stenosis or other source of embolism. 87.8% of patients showed atherosclerotic changes of the carotids, 37.3% signs of ulceration. In patients with ulcers cerebral ischemic events were more frequent than ocular ischemic events. Homogenous plaque formation without signs of ulceration was more correlated with retinal symptoms. Hemodynamically nonsignificant plaque formation in the carotid arteries may be an important cause of cerebral ischemic events. Heterogenous plaques cause bigger embolies than homogenous plaques.

Adult↗