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F Algaba Arrea

Publications and source records attributed to F Algaba Arrea.

13 recordsLinked to original sources
PubMed2004

[Evidence of the radical prostatectomy Gleason score in the biopsy Gleason score].

INTRODUCTION: The Gleason score (Gs) for prostatic cancer has a good prognosis correlation after radical prostatectomy, for this reason its correlation with the Gs in the biopsy can be useful. PATIENTS AND METHODS: Two hundred fifteen patients with blind evaluation among three pathologists of their Gs in biopsy and in the corresponding radical prostatectomy specimen are presented. RESULTS: The exact coincidence is present in 49.7% of cases, 38.6% of cases are under graded in the biopsy and 11.6% of them over graded in the biopsy. No cases of Gs 2 in the biopsy are found. Any case with Gs 3 and 4 in the biopsy are reproduced in the radical prostatectomy specimen. The exact coincidence for biopsy Gs 5, 6, 7, 8 and 9 are 25%, 45%, 72.7%, 36.6% and 60% respectively (kappa 0.32 +/- 0.047, p<0.0001 in Gs 5 to 8). The Gleason pattern 4 is the less diagnosed in prostate biopsies [40% of cases with this pattern in the excision specimen it is missing in the biopsy). CONCLUSIONS: The Gs in the needle prostatic biopsy has a good correspondence with the Gs in the radical prostatectomy specimen. For an increase of the reproducibility it is recommendable avoid the diagnosis of Gs 2, 3 and 4 in biopsy and a scrupulous search for the patterns 4 and 5.

Biopsy, Needle↗
PubMed2000

[Morphologic course of prostatic hyperplasia].

OBJECTIVE: To find a morphologic model of the development of prostate hyperplasia. METHODS: Study of the transitional zone in 60 patients (30 with infravesical obstruction, 30 with no obstructive symptoms) and quantification of the involved surface, number of pure stromal and glandular-stromal nodes, node area for each of them, and non-nodular area of the transitional zone, correlating each parameter to age based on clinical status. RESULTS: The greater transitional zone area is seen in patients with obstruction: 1376.83 +/- 408.17 mm2 vs 321.39 +/- 151.49 mm2 in asymptomatic patients, mainly due to a higher number of glandular-stromal nodes (17 vs 2.2) and their size, with a correlation to age (p = 0.03). Moderate increases of non-nodular areas are also found. CONCLUSIONS: These findings suggest that onset of prostate hyperplasia may be due to a consistent increase of the transitional area, and that in some patients, probably because of local factors, nodular development occurs as a result of both an increase in nodes number and size.

Aged↗
PubMed1999

[Bladder malacoplakia: 14-year follow-up of a case].

OBJECTIVE: To describe the clinical findings, treatment and results of long-term follow-up of a case of malacoplakia of the bladder. METHODS/RESULTS: After diagnostic endoscopic evaluation, transurethral resection of the lesion was performed and antibiotic therapy was administered. The same treatment was repeated 4 years later. During the following 10 years, the patient had a yearly endoscopic evaluation that showed no recurrence of the lesion. CONCLUSIONS: Transurethral resection combined with antibiotic therapy is effective in the treatment of malacoplakia of the bladder. The importance of long-term follow-up of the patient is emphasized.

Anti-Bacterial Agents↗
PubMed1997

[Relationship of prostatic carcinoma of the peripheral zone with glandular atrophy and prostatic intraepithelial neoplasia].

The study of the prostate's peripheral area in 32 patients, with age ranging between 48 to 75 years (mean, 61.4 +/- 6.7), demonstrates the frequency of certain morphological changes such as glandular atrophy (46.8%), which are neither related to age (p = 0.8) or the carcinoma (p = 0.8). A very different issue is the prostatic intraepithelial neoplasia, which although not statistically related to age in this series (p = 0.3) (probably due to the absence of young adults), appears to develop in earlier stages than cancer, is associated in 88.8% carcinomas (p = 0.03) and has a close topographic correlation to latent microscopic foci of adenocarcinoma of the prostate's peripheral area, anatomic proximity of both lesions occurring in 55.5% cases.

Adenocarcinoma↗
PubMed1993

[Determination of prognostic factors in incidental prostatic carcinoma].

Over a ten year period, 5,954 patients with benign prostatic hyperplasia (BPH) were hospitalized in our Institution. Of these, 1,000 cases were randomly chosen for the present study. Surgery was performed in 930 patients: transurethral resection (TUR) in 665 (72%) and open prostatectomy in 265 (28%). The pathological analyses revealed prostatic adenocarcinoma in 36 patients (4%). Seven patients were excluded: 5 due to a short follow-up (less than one year), one who had died from pulmonary embolism immediately postoperatively and one who had developed metastatic disease a few months after the operation. The age of the 29 evaluable patients ranged from 53 to 91 years (mean 72.7 years) and the overall mean follow-up was 43 months. Eighteen patients staged A1 were treated conservatively and followed from 12 to 127 months (mean 53.5 months). Two patients (11%) showed progression, one locally at 42 months (5.5%) and one developed bone metastasis at 15 months (5.5%) and died at 27 months (Mortality: 5.5%). Of the eleven patients with stage A2 prostatic cancer, 7 were managed conservatively (watchful waiting), 1 underwent radical prostatectomy and 3 received early hormone therapy for undifferentiated lesions. Five patients progressed (45%), including the three patients treated with early hormone therapy, 3 local (27%) and 2 systemic (18%). Two of the 11 patients died from cancer (18%) and 2 from unrelated causes. The Gleason grading system and tumor volume (focal or diffuse) were compared as prognostic factors using the Kaplan-Meyer and log-rank test.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMedDate not supplied

[Morphologic keys for the interpretation of the biology of testicular germ tumors].

OBJECTIVE: To review the morphological aspects (classical and molecular) of the natural history of testicular germ cell tumors that have an impact on treatment. METHODS: Data available in the literature published during the last 10 years and the experience of the Pathology Department of the Puigvert Foundation over the last 20 years were reviewed. RESULTS/CONCLUSIONS: Intratubular germ cell tumor is the precursor lesion of testicular germ cell tumors. Its classification into seminoma and non seminomatous lesions continue to be useful for practical purposes. All available data indicate that an intermediate form of seminoma may exist. AFP production is more relevant in tumors of the vitelline sac, therefore determination of AFP in blood could indicate a tumor with this component. Furthermore, vitelline sac tumors may have morphological expressions (epithelial and mesenchymal) that could be the origin of many of the metastases that look like teratoma. One must be cautious in the biological evaluation of teratomas since nuclear atypias are common in the mature teratoma and cell density in the immature teratoma. Evidence of infiltrative growth is the only sign that indicates malignant teratoma. Retroperitoneal germ cell tumors are testicular metastases unless demonstrated otherwise, whereas mediastinal lesions are usually primary tumors.

Germinoma↗
PubMedDate not supplied

[Leydig cell tumor of the testis].

OBJECTIVE: To review our experience with Leydig cell tumor of the testis and compare our findings with those reported in the literature. METHODS: The clinical records of patients with Leydig cell tumor of the testis that were treated in our hospital were reviewed. This study analyzed patient age, reason for consultation, previous history of testicular pathology, size and location of the tumor, US pattern, histological findings, hormone analysis, semen analysis, treatment and clinical course. RESULTS: 7 patients had Leydig cell tumor of the testis, accounting for 2.1% of the testicular tumors treated in our hospital. The mean age at the time of diagnosis was 40 years. The presenting features were enlarged testis, gynecomastia, sexual dysfunction or incidental finding during testicular US assessment for cryptorchidism. Most of the tumors were hypoechoic and showed hypervascularization. Hormone analysis was abnormal in 4 patients and showed reduced testosterone and increased serum estradiol levels. The initial semen analysis showed azoospermia, severe oligozoospermia or cryptozoospermia in 4 patients. Six patients had previously undergone orchidectomy via the inguinal approach and one patient had undergone tumor resection. At 41 months mean follow-up, the tumor has been demonstrated to be benign. CONCLUSIONS: Leydig cell tumor of the testis usually presents as a testicular mass, accompanied or preceded by hormonal changes in 20% of the cases, with feminization in the adult and masculinization in the child. The lesions are always benign in children and in 90% of the adult patients. The US features are usually hypoechoic. The histological criteria for malignancy do not always correlate with the clinical features. Malignancy is established by the presence of metastasis at the time of diagnosis or during follow-up. There is currently no effective treatment for the metastasis. Following orchidectomy, the clinical hormonal manifestations return/remit in 90% of the cases.

Adult↗
PubMedDate not supplied

[Metastatic testicular carcinoma].

OBJECTIVE: To describe 11 cases of metastatic carcinoma of the testicular parenchyma presenting as a scrotal mass. METHODS: A descriptive and retrospective study of metastatic carcinoma of the testis was performed. Eleven cases of testicular metastasis from prostate cancer (7), renal adenocarcinoma (2), bladder carcinoma (1) and carcinoma of the pancreas (1) are presented. RESULTS: All the patients had multiple disseminated disease from their underlying condition, which is a sign of poor prognosis. CONCLUSIONS: Testicular metastasis from carcinoma is rare and frequently arises from adenocarcinoma of the prostate. Clinically, testicular metastases cannot be distinguished from primary tumors and generally affect males over 60 years old.

Humans↗