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Biomedical subjects

F Allegra

Publications and source records attributed to F Allegra.

At least 19 recordsLinked to original sources
PubMed1994

A technique for the biopsy of oral lesions.

BACKGROUND: Biopsy of mucosal lesions can be carried out by means of several methods. OBJECTIVE: To describe a combination technique for the biopsy of mucosal lesions. METHODS: The combined effect of a chalazion forceps with a 4-mm punch allows the physicians to work on a stabilized, bloodless, and therefore simplified field. RESULTS: A preliminary suture with a 4-0 catgut chromic is the key step in assuring a safe post-operative hemostasis. CONCLUSION: This technique allows us to perform accurate and safe oral mucosal biopsies without any major side effects.

Biopsy↗
PubMed1993

Multiple minute digitate hyperkeratoses.

A case of non-familial multiple digitate hyperkeratosis is reported. Digitate hyperkeratosis is a new, non-follicular disorder of keratinization and three different types have been distinguished in the literature: the familial type, with an autosomal dominant trait; the sporadic type; and the post-inflammatory type.

Arm↗
PubMed1991

Prevention of post-herpetic neuralgia. Evaluation of treatment with oral prednisone, oral acyclovir, and radiotherapy.

The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiotherapy was of no value in either the acute or post-herpetic phase.

Acute Disease↗
PubMed1990

[Fluconazole in the treatment of dermatomycoses. Clinical experience].

Twenty patients suffering from dermatomycosis have been treated with fluconazole at the dose of 50 mg/daily for 20 days. These patients (10 M + 10 F) were aged 36 years on average (range 17-65 years). And were suffering from the following: Tinea pedis (3 cases), Tinea cruris (1 case), Tinea corporis (9 cases), Tinea versicolor (3 cases), Candidiasis (5 cases). One patient was suffering from Tinea on two different body sites. 19 patients finished the treatment and reported a complete clinical and mycological healing either at the end of the therapy on at follow-up visits. One patient, who was already suffering from gastritis, had to interrupt the therapy early due to abdominal pain. General safety was excellent.

Adolescent↗
PubMed1983

Macrophage--T-lymphocyte interaction in lichen planus. An electron microscopic and immunocytochemical study.

Papular lichen planus lesions from 12 patients were studied by a double-step immunocytochemical method to detect T-lymphocytes. Semithin sections were studied by light microscopy and ultrathin sections examined by electron microscopy. In the dermal infiltrate, many T-lymphocytes appeared closely juxtaposed to macrophages or Langerhans cells, frequently arranged in a rosette-like pattern. In the epidermis, T-lymphocytes were juxtaposed to macrophages or Langerhans cells and to degenerated keratinocytes. The close relationship between T-lymphocytes, macrophages or Langerhans cells and degenerated keratinocytes supports the hypothesis that lichen planus is immunological in nature: T-lymphocytes, after interacting with macrophages or Langerhans cells, become cytotoxic for keratinocytes.

Humans↗
PubMed1983

T-cell infiltrate in lichen planus. Demonstration of activated lymphocytes using monoclonal antibodies.

Double layer immunocytochemical procedures were performed on fresh frozen serial sections of lichen planus (LP), using three monoclonal antibodies: OKT3 (T-cells) and two anti Ia-like antigens, monoclonal antibodies. Lymphocytes in dermal LP infiltrates were OKT3 positive and Ia-like positive; lymphocytes in the paracortical area of human normal lymph-node were OKT3 positive and Ia-like negative. Unstimulated peripheral blood-OKT3 positive, E-rosette forming cells of normal donors were Ia-like negative, while the same T-cells, when mitogen-stimulated, became Ia-like positive. Therefore, in dermal infiltrates of LP, T-lymphocytes are Ia-like positive cells, representing an antigen-stimulated T-cell population. The in situ presence of activated T-lymphocytes seems to support the hypothesis of an immunological nature of LP.

Antibodies, Monoclonal↗
PubMed1983

[Lyell's syndrome: study of a clinical case].

The Authors report a case of Lyell's syndrome. Previous administration of sulfadossine was identified as the precipitating cause of the syndrome. The clinical history and the treatment of the case are described. Two aspects of the latter were considered to be particularly important: a careful control of the hydroelectrolytic balance and positive action to favour the rapid re-epithelialization of the cutaneous area affected.

Adolescent↗
PubMed1983

Imbalance in phenotypic expression of T cell subpopulations during different evolutional stages of lichen planus lesions.

Immunoenzymatic (in light and in electron microscopy) and immunofluorescence techniques were performed, using monoclonal antibodies, on tissue sections of early lichen planus (LP) lesions versus late LP lesions from 20 patients. Control procedures were carried out in peripheral blood T cells from the same patients and from healthy donors. The OKT4-Leu3A/OKT8-Leu2A ratio in peripheral blood from LP patients and from donors was lower than in dermal infiltrate of early LP lesions, but higher than in dermal infiltrate of late LP lesions. It is conceivable that in early LP lesions OKT4-Leu3A-positive cells may be antigen-specifically 'educated' by immunostimulatory cells. In late LP lesions, OKT8-Leu2A-positive cells could be cytotoxic to keratinocytes; it is likely, however, that this latter population may moreover have immunoregulatory, resolutional functions.

Antibodies, Monoclonal↗
PubMed1983

Identification of macrophages and of a T-lymphocytes subpopulation in normal human lymphnode by histochemical demonstration of alpha-naphthyl-acetate-esterasic activity.

The cell population of normal human lymphnode was studied by a histochemical technique showing alpha-naphthyl-acetate-esterasic activity. Two distinct cell populations were evidenced: a) macrophagic cells, bearing a diffused ANAE cytoplasmic positivity, most of which were in the subcapsular area, whereas a minority of them was found within the lymphatic nodules and the paracortical area; b) lymphocytic cells, bearing on ANAE positive cytoplasmic spot, most of which were in the paracortical area, whereas a minority of them was found within the lymphatic nodules. A discussion of the results we got, as compared with those which are reported by literature, confirms what is already well-known about the cell colonization of the various areas in the lymphnode. Besides it gives a chance to identify lymphocytes bearing an ANAE positive cytoplasmic spot with T lymphocytes belonging to the "helper-inducer" subclass.

Humans↗
PubMed1982

[Atrophic zoniform nevus].

The first, in our knowledge, case of naevus atrophicus zoniforme in italian literature is here reported. A 13 year old girl had a thirteen years history of involved numerous depressed areas of skin of the right anterior region of the chest and of the right upper arm. The lesions were round, grey-bluish, smooth, depressed, completely asymptomatic. No inflammatory changes were noticed in affected patches nor in surrounding normal skin. The histologic changes were compatible with dermal atrophy: epidermis was quite normal; dermis war very thin; the thickness of hypodermis was increased. Some large nervous structures were visible within deep dermis. Histochemical changes mainly involved elastic fibers, whose thickness was considerably increased. The diagnosis of naevus atrophicus zoniforme is discussed, in comparison to other idiopathic atrophies. In conclusion, the main characters of naevus atrophicus zoniforme, according to literature data, are confirmed in our case: 1) congenital appearance 2) zoniforme distribution 3) dermal atrophy 4) thickening of elastic fibers 5) occurrence of large nervous structures in the dermis.

Adolescent↗