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Biomedical subjects

F Aloi

Publications and source records attributed to F Aloi.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Malignant schwannoma of the glans penis].

A 58-year-old man presented with a solitary, asymptomatic, firm nodular lesion on his glans. A simple excision was carried out. Follow-up for 1 year failed to reveal either recurrence or metastases. Histologically, there was intradermal proliferation of atypical oval and spindle-shaped cells arranged in fascicles simulating the pattern of neural tumours. Mitotic figures were abundant. Stains for melanin, HMB-45 antigen were negative. Immunohistochemically, tumour cells stained for S-100 protein and vimentin. Malignant schwannoma usually occurs in patients with neurofibromatosis and is located in the subcutaneous tissues. Solitary malignant schwannoma of superficial soft tissue is a rare entity, and there are problems of differential diagnosis against other spindle cell tumours, especially malignant spindle cell melanoma. Their appearance on the glans is rare.

Biomarkers, Tumor↗
PubMed1995

Agminated Spitz nevi occurring within a congenital speckled lentiginous nevus.

A 40-year-old woman had a speckled lentiginous nevus on her thigh since birth. During her first pregnancy, additional papules and nodules appeared within the preexisting hyperpigmented area, histologic examination of which showed features of both junctional and compound Spitz's nevi accompanied by simple lentigolike changes. In this particular case, speckled lentiginous nevus may have constituted a particular environment for the production of multiple Spitz nevi.

Adult↗
PubMed1994

Chronic venous stasis: not a predisposing factor for basal cell carcinoma on the leg. A histopathological study.

A histopathological study of 125 cases of basal cell carcinoma (BCC; out of 5,475 over a period of 5 years) occurring on the leg was performed. Nodular and superficial BCC were the most common patterns. No sclerosing type was observed, although prominent fibrosis was present in some cases of BCC associated with severe stasis changes. Stasis changes were found only in 25% of the cases suggesting that they do not represent a predisposing factor for the development of BCC on the leg.

Aged↗
PubMed1993

Apocrine carcinoma of the skin. A clinicopathologic, immunocytochemical, and ultrastructural study.

BACKGROUND: Apocrine carcinomas of the skin are rare and incompletely studied neoplasms. METHODS: An immunohistochemical and ultrastructural study is reported of specimens from six patients with apocrine skin carcinoma in various body sites. Three tumors were in the axilla; one, the eyelid; one, the ear; and one, the scalp. There were three local recurrences and three regional lymph node metastases, but no patient died of cancer (follow-up, 2-10 years). RESULTS: The most reliable histopathologic criteria for identifying apocrine skin carcinoma appear to be decapitation secretion, periodic acid-Schiff-positive diastase-resistant material in the cells or lumen, and immunoreactivity with gross cystic disease fluid protein 15. All specimens expressed common epithelial antigens (cytokeratins, carcinoembryonic antigen, and epithelial membrane antigen) and histiocytic-secretive antigens (Leu-M1, lysozyme, LN5, alpha-1-antitrypsin, and alpha-1-antichymotrypsin). S-100 protein was found in the three nonaxillary tumors. Ultrastructurally, the primary tumors, and especially the secondary lesions, were dedifferentiated compared with normal apocrine glands. CONCLUSIONS: Apocrine differentiation in skin tumors does not indicate an exclusive origin from the apocrine sweat glands; these neoplasms usually have an indolent clinical course.

Adult↗
PubMed1993

Proliferative activity in the malignant cellular blue nevus.

The proliferative activity of four malignant cellular blue nevi (MCBN) was assessed in routinely fixed, paraffin-embedded material using staining for the argyrophilic nucleolar organizer regions (AgNORs), immunohistochemical staining for proliferating cell nuclear antigen (PCNA [PC10]), and DNA flow cytometry. The objective was to determine whether the evaluation of proliferative activity could represent a useful diagnostic parameter. Four cellular blue nevi (CBN), 10 melanocytic nevi (MN), four common blue nevi (BN), and 10 conventional malignant melanomas (MMs) were selected as controls. In the MCBN the mean AgNOR number, evaluated on the basis of 100 tumor cells, was 8.33 +/- 0.83; NORs were small and dispersed throughout the nucleus; the mean PCNA score was 31.93% +/- 4.4; and two of the cases were aneuploid and two diploid. In the CBN the AgNOR count was 3.69 +/- 0.56; NORs were large and mainly grouped in a central cluster; the mean PCNA score was 3.53% +/- 1.28; and three of the cases were diploid and one aneuploid. The AgNOR counts in the MCBN were significantly different from those in the CBN (P = .0002), MN (3.04; P = .00001), and BN (2.93; P = .00006), whereas they were not significantly different from those in the conventional MMs (7.64; P = .58). The PCNA (PC10) scores in the MCBN were significantly different from those in the CBN (P = .00003), MN (2.05%; P = .00001), and BN (5.06%; P = .00002), whereas they were not significantly different from those in the conventional MMs (28.9%; P = .49). In all the cases a linear relationship between AgNOR counts and PCNA scores was observed (r = .94, P = .00001). Our results indicate that AgNOR analysis and PCNA immunostaining can be regarded as useful additional parameters for the diagnosis of MCBN.

Adult↗
PubMed1993

Microvenular hemangioma.

We report five cases of microvenular hemangioma, a recently described benign vascular disorder. Clinically, they were acquired, slowly enlarging angiomatous lesions without distinctive features. Histologically, these tumors were characterized by a proliferation of small-sized, irregularly branched, blood vessels throughout the dermis embedded in a desmoplastic stroma. In many areas, the endothelial cells were surrounded by pericytes. The architectural pattern of microvenular hemangioma make its differentiation possible from other cutaneous benign vascular lesions, namely, capillary hemangioma, lobular capillary hemangioma, angioblastoma, and hemangiomas in polyneuropathy, organomegaly, endocrinology, M protein, skin changes (POEMS) syndrome. A close relationship among these vascular proliferations is suggested.

Adult↗
PubMed1993

Seborrheic keratosis-like lesions in epidermodysplasia verruciformis.

A light microscopic study of 6 verrucous lesions with clinical features of seborrheic keratoses (SK) occurring on sun-exposed skin of 4 patients with epidermodysplasia verruciformis (EV) was performed. We observed the typical histological findings of SK in all cases. In addition, koilocytotic effects suggestive of EV were observed in the upper prickle layer and stratum granulosum. In 2 lesions, we also noted bowenoid changes suggesting possible early malignant transformation. Immunohistochemical study confirmed the presence of HPV in these lesions.

Adult↗
PubMed1993

Mycosis fungoides and eruptive epidermoid cysts: a unique response of follicular and eccrine structures.

A case of a patient who developed simultaneously mycosis fungoides (MF) and multiple, tiny eruptive cutaneous cysts on the face, neck and upper part of the trunk is reported. Histologically and immunohistochemically MF infiltrate was recognized not only in the upper part of the dermis and in the epidermis but also around and within the walls of cystic lesions. Furthermore, the eccrine structures were also involved by MF infiltrate. We emphasize that MF infiltrate can affect the follicular and eccrine structures inducing the formation of keratinous cysts. The clinical appearance of the facial lesions may be confused with Favre-Racouchot disease.

Aged↗
PubMed1993

Cutaneous lymphadenoma. A basal cell carcinoma with unusual inflammatory reaction pattern?

Two additional cases of cutaneous lymphadenoma (CL) are reported. The lesions presented as single nodules of many years' duration on the face. Histologically, the neoplasms consisted of irregularly shaped lobules immersed in a dense fibroblastic stroma involving the whole dermis and extending into the subcutaneous fat. Duct-like structures suggesting an eccrine differentiation were recognized. The lobules were composed of a rim of basaloid cells surrounding large epithelioid cells and lymphocytes. In some areas the basaloid lobules were only partly replaced by the inflammatory cells. Immunohistochemically, the intralobular inflammatory component was composed of a mixed B- and T-cell population and S-100-positive dendritic cells. The observation of these cases suggests that CL is not a distinct entity but may represent a basal cell carcinoma, possibly with pilar or eccrine differentiation, in which an immune host reaction pattern is exceedingly unusual.

B-Lymphocytes↗
PubMed1992

HPV-related follicular cysts.

Five examples of follicular cysts with papillary projections protruding into the lumen are given. In all cases, the lining was epidermoid. The cystic cavity contained compact, eosinophilic keratinous material. Groups of vacuolated keratinocytes with overlying tiers of parakeratotic cells were seen on the top of the crests. In the intervening valleys, there were irregular clumps of keratohyaline granules. These changes are diagnostic cytopathogenic effects of viral papillomas. However, papillomavirus common antigens were not identified by immunohistochemistry.

Adult↗
PubMed1992

Pigmented trichoblastoma.

We report a case of trichogenic tumor with epithelial and mesenchymal components recapitulating the formation of hair germs. The epithelial lobules were highly pigmented and affected the full thickness of the dermis, extending into the subcutaneous fat. In addition, amyloid deposits were found within the epithelial lobules and in the stroma. The overall architecture was reminiscent of hair bulbs. Problems of differential diagnosis with other trichogenic tumors and pigmented tumors are discussed.

Adipose Tissue↗
PubMed1992

Eccrine angiomatous hamartoma: a multiple variant.

A case of multiple eccrine angiomatous hamartoma present in a boy since birth is reported. Clinically, this condition must be differentiated from other neonatal angiomatoses. Sometimes the clinical findings are nonspecific, whereas histologic examination may exclude angiomatoses with visceral involvement. In our case the hamartomatous nature of this tumor is documented also by the presence of pilar structures intimately related to the eccrine-angiomatous complex in one of two lesions histologically examined. Therefore, the histologic classification of eccrine angiomatous hamartoma into subgroups seems to be excessive.

Child, Preschool↗
PubMed1991

Argyrophilic nucleolar organizer region counts in malignant melanoma associated with benign intradermal nevus.

A silver colloidal technique to demonstrate argyrophilic proteins of the nucleolar organizer regions (AgNORs) was performed on sections of 20 cases of malignant melanoma (MM) associated with underlying benign nevus (BN). In these cases, significant different AgNOR counts were found for MM and BN. In addition, this technique permitted the identification of melanocytic cells located between malignant and benign cells showing AgNOR scores intermediate (5.51) between BN (2.6) and MM (7.71) with a more complex and bizarre morphology than that observed in BN. The AgNOR technique can be suitable in the identification of residual nevus cells in MM, especially when their number is minimal and the common histologic criteria are unsatisfactory; it can also increase the understanding of the natural history of MM.

Diagnosis, Differential↗
PubMed1991

Papillary eccrine adenoma. A histopathological and immunohistochemical study.

A case of papillary eccrine adenoma of the thigh of a 63-year-old woman is reported. Histologically, the tumor was composed of cystic dilated and branching tubular structures with papillary projections into the lumen, surrounded by a fibrous stroma. In addition, in some areas it was composed almost exclusively of solid strands of epithelial cells. The tumoral eccrine differentiation was assessed by immunohistochemical studies. Problems of differential diagnosis with low-grade sweat gland carcinoma and with tubular apocrine adenoma are discussed.

Cystadenoma↗
PubMed1990

[Eruptive vellus hair cysts: a facial variant].

A case of a 30 year-old man with numerous, pink to whitish, 1-2 mm, cystic lesions, located exclusively on the face and helices in symmetrical distribution is reported. Microscopic examination of serial sections of two biopsies disclosed dermal cystic cavities with vellus hair shafts into the lumen. The cyst wall was connected to rudimentary pilar structures. This picture is typical of eruptive vellus hair cysts (EVHC). Facial variant of this dermatosis is reported only in two cases in the literature. Histogenesis and differential diagnosis are discussed.

Adult↗
PubMed1990

[Maculo-papular juvenile xanthogranuloma. Considerations on a case].

A case of a 6-month-year old child with a yellow, macular and papular, asymptomatic, eruption involving the extremities, upper part of trunk and especially the head is reported. In the early stage histological and immunohistochemical studies were not contributory. Successively, the diagnosis of juvenile xanthogranuloma was made on the basis of the histological, immunohistochemical and ultrastructural findings. Problems of differential diagnosis are discussed.

Arm↗
PubMed1990

[Tricholemmal hamartoma].

A 23-year-old man with a keratotic-nodular lesion localized on the neck since infancy is reported. Histologically, there was a funnel-shaped follicle with central horny material and multiple digitations of the follicular sheath epithelium with some features resembling dilated pore of Winer. In addition, there were pale dyskeratotic epithelial cells in the infundibular portion of the tumor and in the surrounding epidermis. For this unusual tumor the term of tricholemmal hamartoma is proposed.

Adult↗