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F Anaya

Publications and source records attributed to F Anaya.

48 records · Page 3Linked to original sources
PubMed1983

Transfusion-induced anergy: skin test as an index for pretransplant transfusions.

Cell-mediated immunity in vivo was studied by delayed cutaneous hypersensitivity (DCH) to seven antigens in 156 chronic haemodialysis (HD) patients, using a disposable multipuncture device. Anergy was found in 46.8 per cent of patients, and a positive correlation was seen between anergy and female sex, time on HD, glomerulonephritis as primary renal disease, younger age and previous blood transfusions (BT). The effect of BT on DCH was studied prospectively in 29 responsive patients. A significant decrease in DCH response was seen. The transfusion-induced anergy remained for a variable time. The pretransplant BT policy suggested by our data would be to periodically undertake skin tests and to transfuse only responsive patients, thereby avoiding the adverse effects of multiple BT.

Adolescent↗
PubMed1980

[Incidence of renal involvement in Schönlein-Henoch syndrome (author's transl)].

To determine the incidence of renal involvement in Schönlein-Henoch syndrome, authors enrolled in a prospective study all children admitted with this diagnoses from 1971 through 1978. They followed-up 112 patients, which represented the 2 per one thousand of the total hospital pediatric admission in the same period; 22 patients (19.6%) developed renal involvement. After two years of follow-up they observe one patient with progressive renal failure, four with minor urinary abnormalities and 17 asymptomatics. The single patient with renal failure represents the 4.5% of the patients with Schönlein-Henoch nephropathy and the 0.9% of the total affected with this syndrome.

Child↗
PubMedDate not supplied

[Plasma immunoadsorption treatment of malignant multiple sclerosis with severe and prolonged relapses].

INTRODUCTION: The treatment of prolonged, severe relapses in multiple sclerosis (MS) patients who respond poorly to high-dose intravenous corticosteroids is not yet established. Plasma immunoadsortion (IA) removes immunoglobulins (IgG), immune complexes, and complement from plasma. It may bear some advantages compared to plasmapheresis, a nonselective procedure that requires substitution of patient plasma by colloids solutions or plasma, which may carry a potential risk for viral infections. PATIENTS AND METHODS: Three relapsing-remitting MS patients with a malignant course received IA. All they were experiencing a prolonged relapse unresponsive to high-dose intravenous corticosteroids, causing a locked-in state in two of the patients and severe pseudobulbar impairment in the third one. Five to six IA consecutive sessions were administered along a 7-10 days course. RESULTS: IA was followed by a prompt and unequivocal clinical response in all three patients, which paralleled a decrease in IgG, fibrinogen, and C3 complement serum levels. IA administration was followed by immunosuppressor therapy, either with cyclophosphamide and intravenous ACTH (2 cases) or mitoxantrone (1 case). Improvement has been sustained along a mean follow-up of 7.6 years (range: 7-8.5 years), only one of the patients suffering two mild clinical relapses. CONCLUSION: We believe that IA may be useful, either as a coadyuvant or alternative treatment in severe relapses in MS patients that do not respond to high-dose intravenous corticosteroid therapy.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Kidneys from donors less than 5 years of age for transplantation: how to use them?].

We evaluated the results of 27 renal transplants (RT) from donors less than 5 years of age (mean 2.1 +/- 1.1 years). Seven were transplanted en bloc and the rest separately. Fourteen recipients were children and 13 were adults. The overall graft survival at one year was 51%. Kidneys from donors less than 2 years of age that had not been transplanted en bloc had a survival rate of 21%. There was a marked improvement in the one-year graft survival (71%) for kidneys from donors under 2 years of age that had been transplanted en bloc, and a slight improvement (53%) for those from donors over 2 years of age. No urological complications were observed. Five RT were lost due to vascular complications. Good renal graft function was observed in both children (mean plasma creatinine 1.65 mg/dl.) and adults (mean plasma creatinine 1.90 mg/dl.). The one-year graft survival rate was 59% for the adult recipients and 42% for the children. We can conclude from these findings that kidneys from pediatric donors can be transplanted to children as well as adults and should probably be performed en bloc when the donor is less than 2 years of age.

Acidosis↗