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Biomedical subjects

F Andersen

Publications and source records attributed to F Andersen.

14 recordsLinked to original sources
PubMed1992

[The admission and discharge patterns of patients with dementia in psychiatric hospitals].

This paper describes the admission and discharge pattern in a psychiatric hospital for 315 senile and arteriosclerotic demented patients (290.09, 293.09 ICD-8) aged 65 years and over and admitted for the first time. 47% (149) of the patients were admitted from other hospitals and temporary stays in nursing homes. A total of 203 (65%) of the patients experienced one or more changes of residence during the three months prior to admission to the psychiatric hospital. A Kaplan-Meier analysis showed that 25% of the patients were still hospitalized 48 weeks after admission. A total of 62 patients died in the psychiatric hospital, one patient was still hospitalized when the investigation ceased. Of those discharged alive 201, (80%) were discharged to nursing homes 26 (10%) to their own homes and 25 (10%) to hospitals. Of those who had their own home at the time of admission and were discharged alive only 16% were discharged to their own homes, the remainder were discharged to nursing homes and hospitals. On account of the many changes of environment the demented patients experience prior to admission to the psychiatric hospital, they risk developing confusional psychoses which may be disastrous to their physical and mental health.

Aged↗
PubMed1992

[Use of psychopharmaceuticals and commitment in psychiatric admissions of elderly patients with dementia].

Case records of 404 elderly patients (aged 65 years or more) who were admitted for the first time to the Psychiatric Hospital in Aarhus were investigated retrospectively. In 315 patients the diagnoses were senile dementia (290.09) and arteriosclerotic dementia (293.09) according to ICD-8. Information about use of psychotropic drugs before admission and on discharge alive was obtained from the patient case records. In the present study, the use of drugs was not found to be correlated with age, sex and degree of dementia. Significantly fewer committed patients were treated with psychoactive drugs and significantly fewer lived independently in their own homes. Only 42 (13%) patients had a crude psychiatric disorder while 251 (80%) were admitted on account of unacceptable behaviour. 90% of the latter group of patients had been treated with one or more psychoactive drugs on admission. The risks involved in the use of psychoactive drugs are discussed. On account of demographic changes in the Danish population and the recent decrease in psychiatric hospital beds and nursing home beds, it is recommended that the patterns of committed admissions of demented patients to psychiatric hospitals should be followed closely.

Aged↗
PubMed1992

Comparison of two ibuprofen formulations in the treatment of shoulder tendonitis.

In order to compare the efficacy and tolerance of two drug formulations of ibuprofen, conventional tablets 600 mg QID (CI) and sustained-release tablets 1200 mg BID (SRI), a total of 147 patients in 7 centres in Denmark with nontraumatic shoulder pain were included in a double-blind dummy study. Initially all patients received a local injection of corticosteroid and local anaesthetic, and were randomly allocated either drug (CI or SRI) for a period of 3 weeks. Complete relief was recorded from significantly more of the patients in the CI group (21%) than in the SRI group (7%) while a similar number of patients improved viz., 67% of the SRI treated group and 77% of the CI treated group. Based on doctor's assessment improvement in the two groups was equal. 44% of the patients recorded side effects, the number and pattern being the same in the two groups. No serious side effects were recorded. It is concluded that the two treatment regimens can be rated as clinically equivalent.

Adult↗
PubMed1991

[Hydrocephalus complicated by a delirious condition].

A case of normal pressure hydrocephalus (NTH) complicated by delirious psychosis in the initial phase is described. A history of alcohol abuse made the diagnostic assessment difficult. Normal pressure hydrocephalus (NTH) should be considered in cases of delirium with dementia and histories of disturbances of gait or incontinence of urine.

Aged↗
PubMed1991

Ceftriaxone vs. ampicillin + metronidazole as prophylaxis against infections after clean-contaminated abdominal surgery.

In a prospective, controlled, double-blind study, 496 patients undergoing abdominal surgery were given antibiotic prophylaxis with a single dose of either ceftriaxone or ampicillin + metronidazole. No significant intergroup difference was found between the respective overall rates of infectious complications (3.2% and 4.9%). Analysis of the microbiologic findings showed incisional wound infections, mainly caused by gram-negative rods, to be more common in the ampicillin-metronidazole group, whereas deep wound infections were more frequent in the ceftriaxone group. It is concluded that ceftriaxone seems to be more efficient than ampicillin-metronidazole as prophylaxis against incisional wound infection, but should preferably be supplemented with an antianaerobic agent to prevent deep wound infections.

Abdomen↗
PubMed1990

[Sudden infant death and crib death in Scandinavia during the period 1970-1987].

Compared with other countries, infant mortality in the Nordic countries is low. However, the decrease in infant mortality since 1970 has been slower in Denmark and Norway than in Finland and Sweden. The post-neonatal death rate since 1970 has increased in Denmark, Norway and Sweden, but not in Finland. During the same period of time there has been a large increase in cot death in all the four countries, but the incidence has been higher in Denmark and Norway. This may explain much of the difference in today's infant mortality in the different countries. The authors think that the Nordic countries are faced with a serious epidemic situation and propose to appoint a Nordic expert group to follow the trend and find possible pathways for further investigations.

Humans↗
PubMed1989

[Shouting by elderly patients with dementia].

"Shouters" is a term for elderly persons with dementia in whom noisy verbal behaviour is considered to be a problem by the surroundings. Despite the serious nature of the problem, it has not been described in more detail in the literature. An attempt is made to suggest a typological subdivision of "shouters" in this investigation. All elderly persons of 65 years and more who were admitted with the diagnosis of dementia during the period 1.4.1987-31.3.1988 to a gerontopsychiatric department were reviewed. Fourteen of these were described by the nursing staff as "shouters". Half of these presented dementia of multiple infarction type. The problematic behavior could be related to protests/anger, anxiety, loneliness/nostalgia, physical pain or uncertain/possible automatism or self-stimulation. Increased nursing measures or medication had no or only slight effect.

Aged↗
PubMed1989

Enzyme activity electrophoresis: development and applications.

The development of rocket enzyme activity electrophoresis for the detection and quantification of various proteinases, lipases and pectinases is presented. Rocket enzyme activity electrophoresis is more sensitive than the radial diffusion assay and often enables distinction between qualitatively different enzymes present in the same samples, whereas the radial diffusion assay only provides information on the overall enzyme activity. However, calibration and optimization of the enzyme activity electrophoretic assay have to be performed for each new enzyme-substrate system to be analyzed. Some of the common pitfalls in the development of new enzyme activity electrophoretic assays are presented. Enzyme activity electrophoresis can be applied in combination with other electrophoretic assays. Particularly the combination of enzyme activity electrophoresis with various immunoelectrophoretic methods can provide detailed information on the enzymes studies.

Electrochemistry↗
PubMed1989

The effect of different indomethacin formulations in young and elderly patients: a comparative controlled clinical trial.

In a double-blind, crossover trial a controlled-release multiple-units indomethacin formulation (50 mg twice daily) was compared with conventional capsules (25 mg twice daily with 50 mg in the evening) in 12 young and 18 elderly in-patients with rheumatoid arthritis. Earlier findings that younger patients preferred a slow-release formulation and the elderly a standard formulation could not be confirmed. As a whole, the duration of morning stiffness was reduced more (p = 0.02) with the controlled-release formulation than with the conventional formulation. During the treatment period (7 days), 4 patients reported side-effects from the conventional capsules, 3 from the controlled-release formulation, and 6 from both treatments; 53% of the patients preferred the controlled-release formulation, while 20% preferred the conventional capsule (p = 0.046).

Adult↗
PubMed1988

Cost effectiveness of an accurate and rapid assay for serum human chorionic gonadotropin in suspected ectopic pregnancy.

The cost effectiveness and clinical utility of a simple, rapid, and accurate pregnancy test in the evaluation of suspected ectopic gestation were studied. The introduction of this qualitative serum assay for human chorionic gonadotropin into our outpatient department during a 1-month period was associated with a significant decrease in culdocenteses (p less than 0.001), ultrasound examinations (p less than 0.025), and hospital admissions (p less than 0.01), with a net projected institutional reduction in health care costs of +123,000 annually.

Adolescent↗
PubMed1987

Peroperative cefuroxime v. long-term ampicillin and metronidazole in high-risk biliary and gastric surgery. A multicentre trial.

Randomization to cefuroxime in a two-dose peroperative regimen or to combined peroperative and postoperative (4 days) ampicillin and metronidazole was performed in a series of 418 high-risk patients undergoing biliary or gastric surgery. Postoperative wound infection appeared in 9 of the 210 patients who received ampicillin and metronidazole and in 2 of the 208 given cefuroxime (p less than 0.05). Four intraabdominal abscesses occurred in the former group and one in the latter. Three of these abscesses probably were attributable to complications of surgery as such, leaving one intraabdominal abscess in each group. Peroperative cefuroxime is concluded to be more effective than longer administration of ampicillin/metronidazole as protection against wound infection in high-risk patients undergoing biliary or gastric surgery.

Adult↗
PubMedDate not supplied

Ceftriaxone/metronidazole is more effective than ampicillin/netilmicin/metronidazole in the treatment of bacterial peritonitis.

In a prospective, open, controlled clinical study, 190 consecutive patients who were thought to have bacterial peritonitis before operation, were randomised to antibiotic treatment during and after operation with either ceftriaxone 1 g plus metronidazole 1.5 g once daily (n = 94) or ampicillin 2 g plus netilmicin 150 mg twice daily plus metronidazole 1.5 g once daily (n = 96). Incisional and deep surgical wound infections, postoperative pneumonia and urinary tract infection as well as deaths caused by infection were recorded. Ceftriaxone-metronidazole was significantly more effective than ampicillin-netilmicin-metronidazole, 6/94 wound related infections (6%) compared to 18/96 (19%) (p = 0.02). In patients with peritonitis caused by a perforated colon or appendix the rates of clinical failure were 6% and 28%, respectively. We consider ceftriaxone plus metronidazole an efficient and easily administered antibiotic regimen in patients with bacterial peritonitis, and both the wide range of activity against Gram-negative aerobic rods and the long half life of ceftriaxone seem to be beneficial.

Adolescent↗