[Congenital coronary-pulmonary arterial fistula].
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Biomedical subjects
Publications and source records attributed to F Ando.
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Vitreous fluorophotometry was performed on eyes with three kinds of congenital stationary nightblindness: Oguchi's disease (two cases), X-linked congenital stationary nightblindness (two cases), and fundus albipunctatus (one case). The results were compared with the electroretinogram (ERG) and the electro-oculogram (EOG). In spite of the variable degree of abnormality of the ERG and EOG, all eyes showed normal values on vitreous fluorophotometry. These results strongly suggest that the blood-retinal barrier in congenital stationary nightblindness is intact and that the electrophysiological results and the functioning of the blood-retinal barrier do not correlate in these diseases.
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We tested platelet function in seven patients (four men and three women, ranging in age from 26 to 57 years) with bilateral acute retinal necrosis. Hyperaggregation was detected in six of the seven. Antiplatelet therapy (aspirin, 500 mg/day) together with corticosteroids or other drugs produced satisfactory results. Despite administration of antiplatelet drugs, two retinal detachments developed; both were surgically repaired. A lower dosage of antiplatelet agents in one case and late administration of it in another were thought to have caused the retinal detachments. After the acute stage was over or the retina was reattached, there were no further recurrences during a follow-up period of more than one year.
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Factors affecting the surgical results of total anomalous pulmonary venous drainage were evaluated in 17 patients in an attempt to establish an appropriate plan of management. The mortality rate correlated with age, size of interatrial communication, arterial oxygen saturation and left heart volume but not with pulmonary to systemic systolic pressure ratio, vascular resistance ratio and right ventricular volume. In cases where the symptoms appeared early in life, left heart volume was small and clinical features were severe. Four children with a left ventricular end-diastolic volume of less than 65% of normal died of low cardiac output syndrome. In those with an unusually small left heart, enlargement of the left atrium and/or delayed ligation of the anomalous vertical vein were considered more favorable. Left atrial and ventricular volumes were restored to normal after the surgery.
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We studied two kinds of thermoluminescent dosimeters using 60Co gamma rays. In CaF2:Tm, the intensity of the glow curve integral as a function of dose increased linearly; the dose response curve of the main peak (at 165 degrees C) was sublinear and that of the high temperature peak (at 220 degrees C) was supralinear. In CaSO4:DY in LiF, the main peak (at 215 degrees C) and the glow curve integral as a function of dose were linear; the low temperature peak (at 170 degrees C) was sublinear. The relative responses of CaF2:Tm and CaSO4:Dy in LiF were greater than that of LiF (TLD-100) by a factor of about 11 and 4, respectively. In CaF2:Tm, the high temperature peak was very stable, but the main peak faded away with post-irradiation storage time. For CaSO4:Dy in LiF, the main peak was very stable and the low temperature peak was relatively stable. Based on the glow curve integral, we determined that the fading of CaF2:Tm and CaSO4:DY in LiF was 36 and 38%, respectively, for a month.
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Open heart surgery under aortic cross-clamping is often required, but coronary reperfusion injury after release of aortic cross-clamping is unavoidable irrespective of applications of various protective methods to the myocardium. The anterior descending branch of the left coronary artery of mongrel adult dogs was occluded for 2 hours and then reperfused. The protective effects of intra-aortic balloon pumping (IABP) and of a calcium antagonist "diltiazem hydrochloride" (diltiazem) on the decreased reperfusion of ischemic, border and normal areas were examined by measuring the regional myocardial blood flow (RMBF) using a radioactive microsphere method. Diltiazem could increase significantly the RMBF in the border area. IABP induced a significant increase in the RMBF of the same area more than Diltiazem, with the increase in the endocardial layer tending to be superior to that in the epicardial layer. The results suggested that diltiazem is very effective for reducing the coronary reperfusion injury. It is also suggested that IABP is even more effective than diltiazem because it increases the RMBF significantly and, moreover, has a tendency to increase the blood flow in the endocardial layer which is poor in collateral vessels and thus vulnerable to ischemia.
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