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Biomedical subjects

F Annoni

Publications and source records attributed to F Annoni.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Pancreas transplantation. II].

So far no really successful therapy has been found for diabetes mellitus, though it is a common disease and its complications, involving microangiopathy, are extremely serious. The serious limitation of all forms of insulin therapy (various types of insulin and insulin pump) is the impossibility of achieving a fast, successful response to either the variations in blood sugar levels after eating or increased glucogenogenesis caused by glycosteroids and adrenalin. The prolonged hyperglycaemic peaks which result, may well be one of the possible causes of microangiopathy. Only a system which responds to blood sugar variations by stimulating adequate insulin secretion immediately will provide correct prophylaxis for the complications of diabetes mellitus. At the moment only P-pancreatic cells have this capacity and in theory pancreas transplantation seems to be the best treatment for diabetes. However out of 105 complete pancreas transplants only 5 survived for over a year, with the aid of immunosuppressants. Equally none of the 66 allotransplants of pancreatic islands in immunosuppressed patients was successful in the long term. It is also important to bear in mind that long term immunosuppression may prove more dangerous than microangiopathy itself. For these reasons a new cell transplant system using molecular sieve membranes to create an immunological barrier is being investigated. Although it is too early to forecast long-term results, continuous progress is being made and recent discoveries about the physiology of beta pancreatic cells encourage the belief that this approach may be successful in the future.

Cell Division↗
PubMed1981

[Doppler ultrasonic method of blood velocity measurement in Raynaud's phenomenon].

Ten patients, 3 males and 7 females, aging less then 50 years (M: 37), suffering from at least one year for a Raynaud's phenomenon surely not due to a costo-clavicular syndrome, were studied. A Doppler ultrasound evaluation was first done recording the pressure and the speed at the omeral, radial, ulnar, and digital arteries. The patients were then submitted to an angiography in general anaesthesia through puncture of the omeral artery and to screening tests to detect possible associated immunopathological diseases. In the patients affected by Raynaud's phenomenon the vascular lesions are generally distal to the omeral artery; the only surgical indication is a thoracic gangliectomy. Our experience shows that the Doppler velocimetry gives all the data necessary to check the efficacy of a pharmacological treatment and to state a correct surgical indication.

Adult↗
PubMed1980

[Notes on cryosurgery in proctology].

The A. in a review of the outpatient proctologic practice suggest the application of the crioprobe to the piles first and second degree, and to polyps small ones. A pathogenetic hypothesis of this narrowing application is supported on the basis of the unpractible mucosa, affected by 3rd degree piles. Furthermore the N2O employment seems to be unusefull in the treatment of the polyps and a further improvement of the probes is required.

Anus Neoplasms↗
PubMed1979

Venotonic activity of escin on the human saphenous vein.

The venotonic effects of escin on the human saphenous vein have been evaluated in vitro on histologically normal venous segments obtained during surgical saphenectomy procedures. It is necessary to use the human preparations because of the great variability in the responses of the veins of different species. By using a standard stimulus and fitting the experimental data to the logistic function, we were able to compare the activity of escin with those of the commonly used venotonic agents. Stimulation with escin always induced an increase in venous tone which was constant for a given dose and stable for some time, and maintained for as long as an hour after removal of the substance from the bath. The maximum contraction obtained with escin was similar to those obtained with serotonin and dihydroergotamine, significantly greater than that obtained with acetylcholine or vasopressin. However, the affinity of escin was found to be lower than those of the other substances studied. An increase in venous tone, and therefore a decrease in the volume of the venous district, would be considered a very favorable result to be obtained with a drug which, like escin, is indicated for treatment of venous diseases leading to irreversible dilation.

Escin↗