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Biomedical subjects

F Ashton

Publications and source records attributed to F Ashton.

At least 55 records · Page 3Linked to original sources
PubMed1970

Late results of autogenous vein by pass grafts in femoropopliteal arterial occlusion.

The outcome of 185 consecutive autogenous vein bypass grafts for femoro-popliteal occlusions carried out between January 1962 and June 1968 has been reviewed. One patient died at operation and 21 late deaths have occurred since. The overall five-year patency was 61.5%, but was much lower when the popliteal-tibial runoff arteries were diseased. Distal anastomosis of the graft to the popliteal artery below the level of the knee joint also impaired the results, and if this was performed with a graft of minimal diameter less than 5 mm. sustained patency was obtained in only a quarter of the limbs. Nevertheless, where major amputation was imminent owing to advanced ischaemia three out of four limbs were salvaged.

Adult↗
PubMedDate not supplied

Susceptibility of three genetic lines of chicks to infection with a nephropathogenic T strain of avian infectious bronchitis virus.

Mortality rates were compared in three genetic lines of specific pathogen-free chicks inoculated with one of two doses of a nephropathogenic strain of avian infectious bronchitis (IB) virus. The mortality rates were influenced primarily by the chick strain, but also by age and dose of virus. Chicks of the inbred S line were highly susceptible. After inoculation with a low dose of virus at 2 and 4 weeks of age, mortality was 90 and 45%, respectively. Chicks of the HWL non-inbred line were also susceptible, with mortality rates after inoculation at 2 and 4 weeks of age of 70 and 25%, respectively. Chicks of the inbred W line were resistant and non-significant mortality of 10% occurred only in 2-week-old chicks inoculated with a high dose of virus. Viral distribution in tissues of susceptible S and resistant W chicks did not differ, and virus was present in the trachea, lung and kidney of chicks from both lines throughout the acute phase (between days 3 and 7) of infection. Viral titres in the trachea and kidney in susceptible S chicks were slightly but not significantly higher than in the other chicks during the acute phase of infection. Histopathological assessment indicated an earlier onset of a regenerative phase in the trachea of W chicks than in S chicks. S chicks, in contrast to W chicks, showed no signs of renal regeneration. Additionally, the kidneys of S chicks differed from those of W chicks in showing more severe nephritis, more tubular necrosis and less heterophil infiltration and lymphocytic response throughout the acute phase of infection. The results indicate that chicken lines may differ greatly in their susceptibility to fatal IB nephritis and that resistance is likely to be under the control of immune responses to viral infection.

Age Factors↗
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Creativity↗
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Abdominal aortic aneurysms complicated by spontaneous iliocaval or duodenal fistulae.

Seven hundred and twenty one abdominal aortic aneurysms were treated between 1960 and 1985. Twenty one of these (2.9%) were complicated by the development of a spontaneous primary fistula, 16 (2.2%) into the vena cava or iliac veins and 5 (0.7%) into the duodenum. A correct preoperative diagnosis was made in only four instances, two aorto-caval and two aorto-duodenal fistulae. Hospital mortality was 44% for aorto-caval and 60% for aorto-duodenal fistulae. Despite the lack of a precise preoperative diagnosis in the majority of cases, the prognosis for aorto-caval fistula remained comparable to that for patients undergoing emergency surgery for uncomplicated ruptured aortic aneurysms. The mortality of spontaneous aorto-duodenal fistulae was appreciably higher and the aneurysmal contents of 4 out of these 5 cases had positive bacterial cultures.

Aged↗
PubMedDate not supplied

Peripheral arterial embolism. A 20 year review.

Two hundred and forty eight peripheral arterial emboli occurring in 221 patients during a period of 20 years have been retrospectively reviewed. Best results are seen following early surgery with the balloon catheter but, in the clinical absence of tissue necrosis, late embolectomy is worthwhile. Atrial fibrillation and post-myocardial thrombus are the major sources of emboli, but tumour and septic emboli do occur and histological and bacteriological examination of retrieved material is essential. Patients who have sustained myocardial infarction have an increased risk of embolism in the first two weeks and despite modern therapy its incidence remains unchanged. Distinguishing true embolism from acute arterial thrombosis is a continuing problem and different surgical regimes for the two conditions are discussed. Embolectomy following anticoagulation has a high limb salvage rate and a low mortality; anti-coagulation as an adjuvant to surgery also improves prognosis for these patients who have lower amputation rates than those not anticoagulated.

Adult↗