Thyroid function in the preterm infant.
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Fetal Blood↗
Biomedical subjects
F B Diamond
Publications and source records attributed to F B Diamond.
Growth hormone receptor deficiency (Laron syndrome): clinical and genetic characteristics.
Approximately 60 cases of GHRD (Laron syndrome) were reported before 1990 and half of these were from Israel. We have described 47 additional patients from an inbred population of South Ecuador and have emphasized certain clinical features including: markedly advanced osseous maturation for height age; normal body proportions in childhood but child-like proportions in adults; much greater deviation of stature than head size, giving an appearance of large cranium and small facies; underweight in childhood despite the appearance of obesity and true obesity in adulthood; blue scleras; and limited elbow extension. The Ecuadorean patients differed markedly and most importantly from the other large concentration, in Israel, by being of normal or superior intelligence, suggesting a unique linkage in the Ecuadorean population. The Ecuadorean population also differed in that those patients coming from Loja province had a markedly skewed sex ratio (19 females: 2 males), while those from El Oro province had a normal sex distribution (14 females: 12 males). The phenotypic similarity between the El Oro and Loja patients indicates that this abnormal sex distribution is not a direct result of the GHRD.
Body Constitution↗
Regulation of growth hormone secretion. Relevance to the pediatrician.
The regulation of human growth hormone secretion is complex involving both a hypothalamic stimulating and inhibiting hormone. These neurohormones are further regulated by neurotransmitters. Abnormalities in growth hormone secretion may occur in neurologic, psychiatric and metabolic disorders not related to short stature. In addition, the diagnosis of deficiency states of growth hormone secretion can often be very difficult. Guidelines for the work-up of short children are given.
Female↗
Growth hormone neurosecretory dysfunction.
The basis for understanding clinical disorders in the neuroregulation of GH secretion is derived from the complexity of the CNS-hypothalamic-pituitary axis. Studies in animals and humans demonstrate an anatomic, physiological and pharmacological evidence for neurosecretory control over GH secretion including neurohormones (GRH, somatostatin), neurotransmitters (dopaminergic, adrenergic, cholinergic, serotonergic, histaminergic, GABAergic), and neuropeptides (gut hormones, opioids, CRH, TRH, etc). The observation of a defect in the neuroregulatory control of GH secretion in CNS-irradiated humans and animals led to the hypothesis of a disorder in neurosecretion, GHND, as a cause for short stature. We speculate that in this heterogeneous group of children a disruption in the neurotransmitter-neurohormonal functional pathway could modify secretion ultimately expressed as poor growth velocity and short stature.
Amino Acid Sequence↗
A determinant of stature: regulation of growth hormone secretion.
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Adolescent↗
Ectopic and entopic peptide hormone secreting neoplasms of childhood.
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APUD Cells↗
Hypothyroxinemia in sick and well preterm infants.
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Creatine Kinase↗
Long-term effects of minoxidil in the treatment of malignant hypertension in chronic renal failure.
Thirteen acutely symptomatic malignant hypertensive patients were treated with minoxidil in combination with a beta-adrenergic blocking agent and diuretics or dialysis. The degree of endorgan involvement varied, with the kidney being the most compromised in 11 of 13 patients. In 12 of 13 patients, MABP (mean arterial blood pressure) fell significantly within 72 hours, P less than 0.005. After 20 months of therapy, all have now had a favorable response, with a mean reduction in MABP of 48 mm Hg, and with no adverse cardiac disturbances. In addition, the patients with mild azotemia had an improvement in renal function as determined by a reduction in serum creatinine. PRA (peripheral renin activity) rose with the addition of minoxidil despite therapeutic concentration of serum propranolol and a reduction in MABP and heart rate. It was also noted that those patients who had been on guanethidine prior to minoxidil had a more pronounced lowering of MABP within 72 hours of minoxidil therapy. It is concluded that minoxidil is a safe, fast, and effective agent to achieve rapid and sustained control of MABP in malignant hypertensive states associated with chronic renal insufficiency.
Adolescent↗
Patients' prenatal medical record précis.
A prenatal assessment form for ambulatory prenatal patients was designed to provide information required for effective patient care during unscheduled visits or for visits with health-care providers unfamiliar with a patient's history. The abbreviated record enables health-care providers to manage problems before obtaining complete medical records from centralized sources. In two years of use, these abbreviated records have improved both the efficiency and quality of care for unscheduled and scheduled visits.
Ambulatory Care↗