Unpublished NIDR-Eastman Dental Center prenatal fluoride (PNF) study.
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Biomedical subjects
Publications and source records attributed to F B Glenn.
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Physico-chemical investigations of enamel from deciduous teeth of a small number of children with and without pre-natal fluoride supplementation (PNF) exhibited the following differences between the PNF and non-PNF enamel, with the former showing: (a) more homogeneous and less extensive patterns of acid-etching; (b) denser crystal populations in intra-prismatic regions; (c) larger prism dimensions; (d) greater total mineral density (wt%ash); (e) higher degree of crystallinity; (f) smaller a-axis dimensions; and (g) more fluoride and less carbonate contents. On the basis of these preliminary findings, further studies with larger numbers of samples would seem appropriate.
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There exists such a wide margin of safety for prenatal fluoride in regard to fluorosis that 2 mg/day can be used as a simplified prenatal fluoride dosage in all areas, regardless of whether they are fluoridated. Any prenatal fluoride dosage between 1 and 4 mg/day is better than no prenatal fluoride at all.
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