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Biomedical subjects

F B Watts

Publications and source records attributed to F B Watts.

At least 19 recordsLinked to original sources

Complicated appendiceal inflammatory disease in children: pylephlebitis and liver abscess.

Five children with complicated appendiceal inflammatory disease are reported. They presented with nonspecific signs and symptoms, but three had liver abscess and two had inflammation of the portal vein. The inflamed portal vein may act as a conduit to the liver for bacteria, or it may become thrombosed and cause portal hypertension and hypersplenism. In one child, symptomatic portal hypertension developed 10 years after the initial disease. In children, an ultrasonic finding of a focal liver mass of low-to-mixed echogenicity or the presence of low-attenuation areas on computed tomographic scans should suggest the possibility of a hepatic abscess, and the radiologist has a major role in suggesting complicated inflammatory disease of the appendix as the cause. Similarly, when portal vein thrombosis or portal hypertension are found, the radiologist should consider complicated inflammatory disease of the appendix as the cause.

Adolescent↗

Update on pediatric chest imaging.

Even in the high-technology medical imaging arena, the decision of how to first image pediatric chest disease is quite simple: by plain chest radiograph, including frontal and lateral views. The diagnosis can often be made or suggested on the basis of these films or with other basic imaging procedures, such as fluoroscopy or esophagram. From this point onward the decision how to proceed with further imaging such as ultrasound, computed tomography, nuclear medicine imaging, or magnetic resonance imaging, will depend on the probability of gaining further helpful information. Beginning with a concise differential diagnosis allows one to proceed in a logical manner through the diagnostic work-up in a time-effective and cost-effective manner. One must keep in mind that in some cases the diagnosis cannot be made radiologically and must be left to the pathologist. In these cases the work-up should end when no further progress is possible toward making the diagnosis. In the pediatric age group, one should always strive to limit the amount of unnecessary radiation exposure.

Child↗

The renal lesions of tuberosclerosis (cysts and angiomyolipoma)--screening with sonography and computerized tomography.

The two most common sonographic abnormalities in the kidneys of 23 tuberous sclerosis (TS) patients ranging in age from newborn to 30 years are angiomyolipomas (12/23) (AML) and renal cysts (10/23). These usually both occur in the same patient with only 9 cases (39%) having sonographically normal kidneys. Of the 14 affected patients, 2 had cysts without AML and 4 others had AML without cysts. The sonographic appearance of an AML varied from a large 6 cm solid mass with little increased echogenicity (1/12) to subtle small (4 mm) extremely echogenic regions in the periphery of the kidney (11/12). The sonographic appearance of the cysts were anechoic lesions varying in size from 2 mm to 2 cm with thin uniform posterior walls and posterior enhancement. Renal lesions are found more frequently with increasing age. Sonography is the preferred screening procedure for the renal lesions of T.S.

Adolescent↗

Follow-up studies of multicystic dysplastic kidneys.

Thirty cases of multicystic dysplastic kidney (MCDK) were diagnosed over 11 years. Nine patients underwent nephrectomy: three for increasing kidney size (classic MCDK) and six because of an inconclusive diagnosis (hydronephrotic MCDK). Of the remaining 21 patients, 19 were followed up for a mean of 33.5 months (range, 2-101 months). Follow-up ultrasound examinations revealed that 16 kidneys did not change in size, one decreased in size after cyst puncture, and two disappeared (one after cyst puncture). This series included one case of non-renin-producing hypertension that was controlled medically, one case of nephroblastomatosis found in the removed dysplastic kidney, and one case of pyelonephritis in the contralateral kidney. When the diagnosis of classic MCDK is made with imaging modalities, the lesion may not have to be removed unless there is growth of the mass during the 1st year of life. Nine percent of these lesions will disappear within the first 3 years of follow-up, and the authors recommend an even longer period of follow-up.

Child↗

Choanal atresia: precise CT evaluation.

Computed tomography facilitates the diagnosis of children with choanal atresia. This modality defines the full anatomic abnormality of bony choanal atresia: medial bowing and thickening of the lateral wall of the nasal cavity, enlargement of the vomer, and fusion of these elements. Bony atresia patients can be clearly separated from those with membranous choanal atresia. In membranous atresia, the lateral wall of the nasal cavity is minimally affected and the vomer is normal. This precise anatomic evaluation aids in determining the surgical approach.

Child, Preschool↗

Significance of mediastinal metastatic disease in Wilms' tumor of favorable histology.

Although the results of the National Wilms' Tumor Study suggest poor outcome for children with metastases to intra-abdominal, intracranial, skeletal, skin, diaphragm, or mediastinal sites, the incidence and course of mediastinal disease has not been described. Fifty-four newly diagnosed Wilms' tumor patients at Children's Hospital of Michigan (1972-1980) were studied for patterns of intrathoracic metastases. All had favorable histology; mean age (MA) at diagnosis was 4.5 years. Initial chemotherapy ranged from single agent to three-drug combination (actinomycin, vincristine, adriamycin). Intrathoracic metastases occurred in 14 (26%) from 0-28 months (median, 3.5 months) from diagnosis (MA, 5.8 years). Upon the discovery of intrathoracic metastases all received radiation (1,200-2,000 rads) to the chest, some with supplementary doses to the mediastinum. Five children with parenchymal and one with parenchymal and hilar metastases appearing 0-28 months after the time of diagnosis survive disease-free 44-127 months after metastases appeared (MA, 6.3 years). Eight children developed parenchymal and mediastinal metastases (MA, 5.4 years). Time from diagnosis to parenchymal metastases was 0-7 months; time from diagnosis to mediastinal metastases was 0-16 months; and in four, both sites appeared simultaneously. Death occurred in all eight patients 7-25 months from diagnosis. Only one child had evidence of recurrence outside the chest. Potential risk factors and influence on survival are discussed.

Adolescent↗

Asymptomatic intracardiac metastasis from osteosarcoma: a case report with literature review.

Osteosarcoma very rarely metastasizes to the heart. Thirteen cases have been reported in the literature so far. Diagnosis in some of these cases was made during investigation for severe cardiac failure and in most of them at autopsy. Our patient, a 13-year-old girl, showed right pulmonary metastases on chest x-ray 1 year after above knee amputation for osteosarcoma of the distal femur. Routine preoperative computerized axial tomography (CT Scan) revealed a calcified lesion in the heart in addition to the pulmonary metastases. She was very active and completely asymptomatic. Two-dimensional echocardiography, angiography, and right and left heart catheterizations were done. This revealed a large mobile metastatic lesion in the right ventricle. The intraventricular tumor was successfully removed, and 12 days later she had a second thoracotomy for removal of pulmonary metastases. Nine months after her intraventricular metastasis was removed she developed a solitary right pulmonary metastasis. This was successfully resected. Now, 10 months later, she is disease free and completely asymptomatic.

Adolescent↗

Ureteral triplication with a ureterocele.

Ureteral triplication is a rare anomaly of the upper urinary tract. The occurrence of complete ureteral triplication with an associated ureterocele has only been reported once before. A case of this extremely rare association is described, and the embryology of this condition is discussed.

Female↗

Computed tomographic diagnosis of an intracardiac metastasis from osteosarcoma.

A report of the demonstration of an asymptomatic intracardiac osteogenic sarcoma metastasis by computed tomography. This metastasis was successfully excised along with associated pulmonary metastases. Intensive chemotherapy and aggressive surgical excision of metastatic osteosarcoma lesions have resulted n 40%-60% long-term survival in these patients.

Adolescent↗

Incomplete rotation of the intestine with a normal cecal position.

Nineteen patients with incomplete rotation of the intestine, seen during a 3-year period, are presented. Six patients (32%) had a normal cecal position but an abnormal duodenojejunal junction. Three of these patients had a midgut volvulus, and one had obstructing duodenal bands. The two remaining patients were premature and had postnatal fixation of the duodenojejunal junction over a 10-month to 2-year period.

Cecum↗

The urinal artifact.

Abrupt narrowing of the male anterior urethra has been increasingly observed during voiding cystourethrography due to extrinsic pressure from a urinal. The true nature of this narrowing must be recognized to avoid misinterpretation.

Humans↗

The enlarged epiglottis.

Three children are presented with radiologic evidence of epiglottic enlargement who did not have acute epiglottitis. The radiological and clinical differentiation of these entities (angioneurotic edema, foreign body, and chronic epiglottitis) are discussed.

Acute Disease↗