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Biomedical subjects

F Babusíková

Publications and source records attributed to F Babusíková.

15 recordsLinked to original sources
PubMed1978

Resting values of left ventricular work to coronary blood flow ratio in rats exposed to intermittent high altitude hypoxia and swimming.

Total hemodynamic values and left ventricular blood flow were studied using Sapirstein's method of 86Rb uptake in female rats 24 h after a last exposure to high altitude. A stimulated altitude of 1350 m was used, initial exposure being for 30 min, gradually increased by 30 min daily up to 330 min daily for 5 days a week; the total number of exposures was 32. In another animal group the hypobaric exposure was combined with swimming in water at 37 degrees C. In both experimental groups the cardiac output and stroke volume increased, and in rats undergoing swimming the total peripheral resistance decreased as well. In the rats exposed to intermittent hypoxia only, left ventricular blood flow increased by about the same proportion as the cardiac output. The ratio of left ventricular work to coronary blood flow was significantly increased. In rats exposed to the combined influence of hypoxia and swimming, the increase in left ventricular blood flow did not match either the increase in cardiac output, or the weight gain of the left ventricle. The ventricular work to coronary blood flow ratio was the same as in controls.

Animals↗
PubMed1976

Influence of alpha-adrenergic block and beta-adrenergic stimulation on distribution of cardiac output after cardiopulmonary bypass.

Organ and tissue damage restricts total cardiopulmonary bypass to a few hours in patients. The cause might be the disturbance of tissue flow in which the sympatho-adrenal hyper-activity plays a decisive role. In dogs, killed 30 min after cardiopulmonary bypass was stopped, we studied the tissue distribution of cardiac output with the method of Sapirstein. In one group the alpha-adrenergic blocker, in the other one the beta-adrenergic stimulator was continuously applied during the whole operation-period. Compared to a control group the per cent of cardiac output as well as the regional tissue flow after alpha-adrenergic block increased in the liver, ileum, adrenals, testes, kidney and in the skin and decreased in the spleen and thyroid gland. After beta-adrenergic stimulation the per cent of cardiac output increased in the heart muscle, lungs, liver, ileum, adrenals and m. soleus and decreased in the spleen and thyroid gland. The absolute values of organ tissue flow increased in ileum and decreased in the spleen, thyroid gland and in the kidney.

Adrenergic alpha-Antagonists↗
PubMed1975

Activity of catecholamines inactivating enzymes in heart muscle during anoxic cardioplegia in cardiosurgical patients.

On the model of anoxic cardioplegia in cardiosurgical patients the influence of anoxia on the activity of monoamine oxidase (MAO) and catechol-O-methyltransferase (COMPT) in right auricular tissue was studied. It was found out that the activity of COMT does not change during anoxia, the activity of MAO considerably increases. With regard to catecholamines stimulating effect upon cardiac metabolism as well as to their calorigenic and oxygen wasting effect the raise of MAO activity may be regarded as favourable phenomenon, because the hastened degradation of released catecholamines at least to a certain degree diminishes the disproportion between oxygen supply and actual oxygen need of the heart and by means of that mitigates the anoxic damage of myocardium.

Cardiac Output, Low↗