[Proliferation kinetics of the rectal mucosa in ulcerative colitis patients (author's transl)].
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Adult↗
Biomedical subjects
F Baldi
Publications and source records attributed to F Baldi.
Chronobiological study of pituitary adenomas and of the empty sella syndrome.
A chronobiological study was carried out in pituitary GH- and PRL-secreting adenomas and in the empty sella syndrome. The circadian rhythms of plasma GH and plasma PRL were abolished respectively in GH- and PRL-secreting pituitary tumors, and they were again detectable after selective transsphenoidal adenomectomy. In the empty sella syndrome only the chrono-organization of GH secretion was disturbed, whereas plasma PRL exhibited the usual circadian pattern. A normal circadian rhythmicity of plasma cortisol was demonstrable in the 3 groups of patients. The diagnostic significance of the chronobiological findings obtained is discussed.
17-Hydroxycorticosteroids↗
Fatal tubular nephropathy following an overdose of theophylline in an infant.
A case of fatal acute intoxication in a 4-month and 20-day-old male infant from an overdose of theophylline (Paidomal) drops retard is described. Apart from the usual symptoms caused by theophylline overdose, severe obstructive tubular nephropathy was also observed.
Drug Overdose↗
Role of PCNA in differentiating between malignant mesothelioma and mesothelial hyperplasia: prognostic considerations.
We investigated the PCNA immunoreactivity in 35 specimens of malignant mesothelioma and 20 specimens of mesothelial hyperplasia in order to evaluate the usefulness of this parameter in differentiating between these two mesothelial proliferations, and to determine whether PCNA has any prognostic significance in mesotheliomas. Eleven of the 35 investigated malignant mesotheliomas displayed up to 25% of positive cells for PCNA expression. The remaining 24 specimens showed high percentages of positive cells ranging from 26% to 95%. All specimens of reactive hyperplasia had less than 25% of PCNA positive cells. The difference between malignant mesothelioma and mesothelial hyperplasia for PCNA immunoreactivity was statistically significant (p < 0.01). A positive relationship was also found between PCNA expression level and the overall survival of those affected by malignant mesothelioma (p = 0.0032). Our results suggest on important role for PCNA in differentiating diagnosis of mesothelial proliferations. It remains unclear whether PCNA expression truly correlates with the proliferation rate of the malignant mesotheliomas and with the overall survival of patients affected by this neoplasm.
Adult↗
p53 immunostaining in differential diagnosis of pleural mesothelial proliferations.
We evaluated tissues for the overexpression of p53 protein in 35 malignant mesotheliomas and 20 reactive pleural hyperplasias, obtained from open biopsies or pleurectomies. Of the 35 neoplasms investigated, 30 (85.7%) displayed positive nuclear staining for p53. No staining was seen in any specimens of hyperplasia. We found no significant statistical difference in p53 expression when we compared p53 overexpression in the different histological subtypes of mesotheliomas. Moreover, p53 overexpression did not correlate in a statistical manner with survival. We conclude that p53 overexpression is a frequent feature of pleural mesothelioma and is useful for routine differentiating between malignant and non-neoplastic mesothelial alterations. The reason for p53 overexpression in mesothelioma, however, remains to be determined.
Adult↗
Prognostic role of proliferating cell nuclear antigen in lung cancer: an immunohistochemical analysis.
Proliferating cell nuclear antigen (PCNA) is a 36 kDa protein acting as a subunit of DNA polymerase delta, and is therefore associated with DNA replication. Its involvement in DNA excision repair after DNA sub-lethal damage has been reported. We assessed the immunohistochemical expression of PCNA in 94 lung cancer specimens in order to evaluate its potential relationship with clinical history and the outcome of the evaluated patients. We found PCNA protein expressed in all the evaluated neoplastic specimens, but with different expression levels. In addition, our results showed a subgroup of patients (high expressors) having a statistically significant worse outcome compared to the other two groups of patients, independently of' any other clinico-pathological feature. In conclusion, our data highlight the central role of PCNA and estimation of the proliferation rate in the prediction of the prognosis of lung cancer patients.
Adenocarcinoma↗
RB growth control evasion in lung cancer.
We evaluated the expression of pRb by immunohistochemistry in 98 lung cancer specimens already characterized for their p16 and cyclin D1 status. We found the absence of pRb expression to be dependent upon the histological type, being more frequent in SCLCs than in NSCLCs (p < .00005). On the other hand, we failed to find any correlation between the expression of pRb and p16. In addition, we found a positive correlation between the expression of pRb and cyclin D1 (p = .0001). Therefore, we hypothesize that pRb growth control may be overcome by two different mechanisms in lung carcinogenesis: loss of pRb expression or overexpression of cyclin D1.
Adenocarcinoma↗
Crohn's disease in infancy: a case report.
Crohn's disease in infants is infrequent. We describe here the case of a baby girl born at the 33rd week of pregnancy, that underwent surgery at the age of 55 days for intestinal occlusion. This was found to be due to stenosis of the right colonic flexure associated with cecum, appendix and terminal ileum. Microscopic examination showed features consistent with Crohn's disease. Eleven years after surgery, followed by cortisone therapy, the patient shows normal growth and is asymptomatic.
Crohn Disease↗
Lymphomatoid granulomatosis of the lung: a clinico-pathological study.
Lymphomatoid granulomatosis is the only form of pulmonary angiitis histologically characterized by a necrotizing angiocentric and angiodestructive lymphoid infiltrate, with an admixed T-cell reaction. We evaluated three patients with a single lung nodule not diagnosed by routine radiological and endoscopic assays. Our investigations showed a prevalence of T-cells in areas of diffuse infiltration, which were actively replacing reactive follicular areas of B-cells, similarly to T-cell lymphomas. Further pathologic assays suggested the histologic diagnosis of grade I lymphomatoid granulomatosis for all three evaluated specimens. After two years, patients treated with a combination of surgical resection and chemotherapy were disease free, supporting the efficacy of aggressive therapy in the management of this often mistreated group of lymphoid proliferations.
Antigens, CD↗