PubMed Health⌕ Search

Biomedical subjects

F Barillà

Publications and source records attributed to F Barillà.

28 records · Page 2Linked to original sources
PubMed1993

[Predictive value of various echocardiographic parameters of systolic and diastolic function in the development of congestive heart failure after infarction].

To evaluate the predictive value of systolic and diastolic left ventricular (LV) function parameters, in the development of congestive heart failure (CHF) after acute myocardial infarction (AMI), 48 patients (mean age 56.2 +/- 10.4 years) were studied with two-dimensional and Doppler echocardiography (2D echo) in the acute phase (36 +/- 12 hours) and after 6 months of follow-up. The following parameters have been evaluated: LV wall motion score-index; peak velocity of early diastolic filling (E); peak velocity of filling during atrial systole (A); the ratio A/E; percent of LV filling contributed by atrial systole (A%). During follow-up 10 patients (Group B; 21%) developed symptoms and/or signs of CHF, while 38 patients (Group A; 79%) did not. In the patients who developed CHF 2D echo showed a depressed contractile function (mean value of wall motion score-index 3.08 +/- 0.45 versus 3.53 +/- 0.32 of Group A; p < 0.001) and a marked impairment of filling during atrial systole: A/E = 1.89 +/- 0.80 versus 1.07 +/- 0.35 (p < 0.001); A% = 52.2 +/- 9.9 versus 39.1 +/- 8.4 (p < 0.001). The multivariate analysis showed that the ratio A/E, A% and the wall motion score-index are the only variables that may predict the development of CHF. This capacity has been confirmed also considering the cut-point as conditional variables (A/E > 1.4; A% > 45%; score-index < 3.1). Our results demonstrate that a combined evaluation by 2D echo of systolic and diastolic LV function parameters allowed a better stratification of patients at risk of developing CHF after an AMI.

Adult↗
PubMed1991

[Angiocardiographic evaluation of the left ventricular function in adult and pediatric subjects with interatrial defect of the ostium secundum type].

In order to assess left ventricular function in adults and children with ostium secundum atrial septal defect (ASD), 42 patients were examined by hemodynamic and angiocardiographic techniques. Patients were divided into three groups: Group I, 18 patients (mean age 42 years) with ASD; Group II, 14 patients (mean age 9 years) with ASD; Group III, 10 patients without cardiopathies who represented the control group. The following parameters of ventricular function were assessed: left ventricular end diastolic volume, global and regional left ventricular ejection fraction, left ventricular telediastolic pressure, mean pulmonary artery pressure, the ratio between pulmonary flow and systemic flow (QP/QS). Group I patients showed higher values of left ventricular end diastolic pressure and mean pulmonary artery pressure (16 +/- 0.6 mmHg; 33 +/- 1.5 mmHg) in relation to those of Group II (5.1 +/- 0.4 mmHg; 14 +/- 1.4 mmHg) and Group III (8.1 +/- 0.5 mmHg; 18 +/- 1.6 mmHg). In both cases the difference was statistically significant (p less than 0.001). A significant difference (p less than 0.05) was also noted in the incidence of mitral valve prolapse between patients in Group I and II. There was no significant difference (p = NS) however, between overall ejection fraction values in the three groups of patients; a lower regional ejection fraction (postero-basal segment) was recorded in Group I patients with mitral valve prolapse in comparison to patients in the other two groups (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

Acute effects of nifedipine versus isosorbide dinitrate on exercise tolerance in patients with isolated coronary artery occlusion and collaterals.

The acute effects of slow-release nifedipine and isosorbide dinitrate on exercise tolerance were compared in nine patients with isolated total coronary artery occlusion showing retrograde filling via collaterals. All patients had a reproducible positive exercise stress test off medication before the study. Each patient was randomized to 10 mg slow-release nifedipine and 5 mg isosorbide dinitrate in a single-blind, cross-over study. The exercise stress test was performed 30 minutes after drug administration. After nifedipine, three patients had a negative exercise stress test, whereas the test was negative after isosorbide dinitrate only in one patient. A significantly higher exercise tolerance was detected at peak exercise after nifedipine than after isosorbide dinitrate, as shown by a longer exercise time (380 +/- 44 vs. 295 +/- 41 seconds, p less than 0.001), a more increased maximum work load (355 +/- 89 vs. 255 +/- 55 W x min, p less than 0.02), and a higher rate-pressure product (30,300 +/- 2,500 vs. 26,100 +/- 2,700, p less than 0.01). In conclusion, these results seem to suggest that nifedipine may have a vasomotor effect on collaterals, since it elevated the threshold of ischemia more than isosorbide dinitrate did in patients with isolated coronary artery occlusion, showing retrograde filling via collaterals.

Angina Pectoris↗
PubMed1990

[The role of emotional stress in pathogenesis of gastrointestinal diseases and the importance of psychopharmacologic combinations in their treatment].

In view of the importance of the emotional stress in some gastrointestinal diseases pathogenesis among which anxiety and/or depression appear to play an appreciable role, the Authors have analysed a number of sensitive colon and duodenal ulcers whose psychopharmacologic treatment has resulted crucial in the resolution of these diseases.

Animals↗
PubMed1990

[Importance of the genetic aspect in hypertrophic cardiomyopathy].

Hypertrophic cardiomyopathy is a disease characterised by massive ventricular hypertrophy, reduced diastolic function and excessive ventricular contraction. It involves sections of both ventricles, but in particular the left ventricle. Although it was initially thought that this pathology might depend on a modified systolic function, it is now widely held that the main alteration is of a diastolic type. The paper focuses on the importance of the genetic component in this cardiopathy, and stresses that the majority of patients affected by this disease and examined by the Authors had positive family histories, in line with previously published reports. In the majority of cases the pathology is transmitted in a dominant autosomic manner, although there are also sporadic episodes of non-hereditary transmission due to genetic mutation.

Cardiomyopathy, Hypertrophic↗
PubMed1989

[Effects of slow-release isosorbide-5-mononitrate on ergometric parameters and cardiac output in stable effort angina pectoris: a double-blind randomized placebo study].

The effects of a single oral dose of 60 mg of sustained release (R) isosorbide-5-mononitrate (ISM) administered in 9 male patients (mean age: 53 +/- 7 years) with stable exercise-induced angina pectoris were studied in a randomized, double blind, cross-over study. The effectiveness of the drug was evaluated by concomitant ergometer exercise stress test and cardiac output determination (bioimpedance method, Bomed Med-Ltd) performed 1 hour before and 1, 4, 10 and 24 hours after acute administration of placebo (P) and ISM-R. After P, all patients showed a positive exercise test, whereas 3 patients during ISM-R treatment had a negative exercise stress test 1 and 4 hours after ISM-R administration. Compared with P, ISM-R produced a statistically significant improvement of exercise stress test parameters at peak exercise (maximum work load, heart rate, systolic and diastolic blood pressures and double product) up to 10 hours after drug administration. On the other hand, cardiac output did not significantly differ at any time after ISM-R compared with both control conditions and P treatment. Moreover, no side effect was detected in any patient during the study. In conclusion, a single oral dose of 60 mg of sustained-release ISM-R seems to be an effective drug in the treatment of effort angina, its effectiveness lasting more than 10 hours without side effects.

Adult↗
PubMedDate not supplied

[Variations of plasma renin in hemodialysis].

We evaluated the variations of serum renin concentrations during hemodialysis in 17 patients (5 hypertensive and 12 normotensive). In addition we have studied the relationships between serum renin levels, right heart atrium diameters, arterial pressure, and body weight. At the end of the hemodialytic process we observed in both groups of patients an increase in the serum renin concentrations, as well as changes in the above parameters.

Aged↗
PubMedDate not supplied

Detection of coronary artery stenoses using breath-hold magnetic resonance coronary angiography. Comparison with conventional x-ray angiography.

PURPOSE: To detect coronary artery stenoses, we compare breath-hold magnetic resonance coronary angiography (MRCA) to conventional coronary angiography (CA). MATERIALS AND METHODS: Sixty-five patients with suspected coronary artery disease underwent MRCA and CA within one week. MRCA examination was performed by using the two-dimensional (2D) breath-hold technique with a fast spoil gradient-echo sequence/spiral. Each imaging sequence was obtained within one breath-hold in expiration (14 seconds of apnoea). The assessment of coronary artery stenoses on magnetic resonance (MR) angiograms was independently performed by two blinded readers and compared to conventional CA images. RESULTS: Three hundred and ninety segments were evaluated by the two imaging techniques. MRCA correctly detected 76 of 88 (86%) stenoses, and recognized 242 of 302 (80%) not affected segments. The Pearson correlation coefficient between MRCA and CA in assessing coronary narrowings was very high: r = 0.85. Despite this the mean difference was 4.5 with a standard error of estimate of 0.21, indicating that MRCA slightly overestimates the degree of stenoses. CONCLUSIONS: Our study showed that 2D breath-hold MRCA is an accurate technique in displaying and quantifying the most significant stenoses in the proximal and middle segments of the coronary arteries.

Adult↗
PubMedDate not supplied

Correlation between angiographic success and functional improvement assessed by exercise test following percutaneous transluminal coronary angioplasty.

Sixty-one consecutive patients with stable effort angina and single vessel disease underwent successful (reduction of coronary stenoses by greater than or equal to 20%) percutaneous transluminal coronary angioplasty (PTCA). Anatomical results were analysed on the basis of functional evaluation obtained by exercise test (ET) 1 week before (pre-PTCA) and within 1 month after (post-PTCA) PTCA. Total exercise duration and maximal double product significantly increased after PTCA (4.5 +/- 1 min vs 6.9 +/- 1.5 min, p less than 0.001 and 14.1 +/- 3.6 x 1000 mmHg x bpm vs 18 +/- 4.2 x 1000 mmHg x bpm, p less than 0.001). Pre-PTCA ET was positive in 43 patients (70%) and post-PTCA ET in 15 (24%). In patients with post-PTCA positive ET, mean stenosis diameter reduction was significantly lower than that obtained in patients with negative post-PTCA ET (29.6 +/- 8.9% vs 61.1 +/- 18.8%, p less than 0.001). In conclusion, PTCA improved exercise tolerance in the majority of patients with myocardial ischemia, however the definition of anatomical success used in this study appears to be poorly correlated with functional improvement as assessed by ET.

Angioplasty, Balloon, Coronary↗