Biomedical subjects

F Bart

Publications and source records attributed to F Bart.

20 records · Page 2Linked to original sources

PubMed1986

[Mechanisms of allergic asthma].

The patho-physiology of allergic asthma is the result of several closely interrelated mechanisms. The hypersensitivity to mediation by IgE implies mast cell intervention and also by other non-mast cells possessing a receptor for Fc fragments of IgE. Their activation leads to the liberation of numerous mediators, some of which act directly on the bronchial smooth muscle fibres whilst others intervene by "pro-inflammatory effects". The other essential compound of asthma is non specific bronchial hyperreactivity. In reality the two phenomena are closely linked as is shown with changes in bronchial hyperreactivity after exposure or the inverse, by elimination of the allergen. The slow reaction linked to IgE by the cellular influx which it provokes in the airways amplifies the local inflammatory reaction and by this interacts with the autonomic nervous system.

Adrenal Cortex Hormones↗

PubMed1986

[An unusual cause of right-left shunt: anastomosis of the left superior vena cava with the left atrium].

We report the case of a 73 year old man presenting with severe hypoxaemia due to an anatomical right to left shunt from a persistent left superior vena cava (VCSG) anastomosing with the left auricle. This was fortuitously discovered while placing a left sub clavicular catheter; the diagnosis of the VCSG draining into the left auricle was confirmed by superior phlebography and CT scanning. The discovery of this shunt after a pulmonary embolus suggested to us that the rise in venous pressure secondary to the embolus led to both clinical symptoms and hypoxaemia from the shunt, which had until then been clinically silent. No surgical treatment was performed.

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