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Biomedical subjects

F Beersiek

Publications and source records attributed to F Beersiek.

16 recordsLinked to original sources
PubMed1984

[Neurogenic myopathy of pelvic floor and sphincter musculature in idiopathic incontinence].

The underlying cause of so-called idiopathic incontinence is probably neurogenic myopathy. As compared with a control group, 16 patients with anorectal incontinence were found to have a type I fibre predominance in the external and sphincter, the puborectal and levator ani muscles. The mean diameter of type II fibres was greater in external sphincter and puborectal muscles of the control group. In contrast, the mean diameters of type I fibres in female subjects of the control group were significantly greater than that of type II fibres. In patients with incontinence, marked fibre hypertrophy of both histochemical fibre types was observed. This finding was most evident in puborectal and external anal sphincter muscles. In 12 of the 16 incontinent patients under study, histological and statistical findings indeed appeared to be due to neurogenic damage of the sphincter muscles. Birth trauma or stretch injury due to excessive straining on defecation represent causes of damage to the pudendal nerve which innervates the anal sphincters. Tensioning of the external sphincters to restore the anorectal angle as in the Parks' technique of post-anal repair appears to be a promising form of treatment of idiopathic incontinence.

Adult↗
PubMed1980

[Sphincter function after rectal resection with peranal anastomosis (author's transl)].

To test sphincter function after rectal resection with colon-anal anastomosis performed with Park's peranal technique, 17 patients were examined using the Kelly code and manometric studies. Compliance and anal resting pressure were reduced. Sphincter internal relaxation after rectal distension was also less compared to the norm. Continence was normal for 10 patients and 4 had satisfactory function.

Aged↗
PubMed1979

[Results of 200 renal transplantations (author's transl)].

Two hundred renal transplantations were performed on 187 patients between July, 1972 and June, 1978. On a follow-up of 6--78 months the survival rate after allogenic transplantation was 80% at one year and 64% at five years. Satisfactory renal function was present in 62% at one year and 31% at six years. Gastrointestinal complications were common and caused about 40% of all deaths. Severe infections were the second most common cause of death. Local complications required explantation in 4%, and caused death in 0.5% of cases. Change in the treatment regimen, using less massive immunosuppressive measures during acute rejection, lowered the death-rate without a higher loss of transplants. The death-rate was 16% at three months and 26% at one year in the first of the 200 transplantations, but 6% and 12%, respectively, in the last 50 consecutive transplantations. The survival rate of patients with transplants is thus comparable to that of patients receiving chronic haemodialysis.

Azathioprine↗
PubMed1979

[Angiopathy in a case of primary oxalosis combined with familial spherocytosis (author's transl)].

An 18-year-old female with primary oxalosis, seen first when she was in advanced renal failure, developed a severe necrotizing angiopathy which began after a rapid decrease in renal function requiring chronic dialysis. Because of the severe angiopathy the preliminary diagnosis of an acute autoimmune vasculitis had been made. The correct diagnosis was revealed by renal biopsy and a renal transplantation performed. Soon after severe oxalosis led to failure of the renal transplant and death. The patient had also had familial spherocytosis, inherited from her father, while the oxalosis had been inherited from her mother. It is suggested that early transplantation at the onset of renal failure, as long as the blood oxalate level is still tolerably low, may give better results than have so far been reported.

Adolescent↗
PubMed1979

Pathogenesis of ano-rectal incontinence. A histometric study of the anal sphincter musculature.

Type 1 fibre predominance was found in the external anal sphincter, puborectalis and levator ani muscles of 17 control subjects, and of 16 patients with ano-rectal incontinence. In the external anal sphincter and puborectalis muscles of the control subjects the mean diameter of Type 2 fibres was slightly greater than that of Type 1 fibres, but in the levator ani muscles of control female subjects the mean diameter of Type 1 fibres was much greater than that of Type 2 fibres. In the patients with anorectal incontinence there was marked hypertrophy of fibres of both histochemical types. This was most marked in the puborectalis and external anal sphincter muscles. In 12 of the 16 incontinent patients there were histological and statistical features consistent with a neurogenic disorder. These histometric studies provide a quantitative basis for physiological and pathological studies of these muscles in incontinence and other anorectal disorders.

Adenosine Triphosphatases↗
PubMed1978

[Thrombectomy for acute renal-vein thrombosis (author's transl)].

Three personal cases are presented to indicate the growing need for thrombectomy as a method of treatment of renal-vein thrombosis. In addition to known causes of renal-vein thrombosis (e.g. iatrogenic, post-traumatic) there is the so-called spontaneous renal-vein thrombosis especially in newborns. The possibility of renal-vein thrombosis must be considered in the presence of sudden, circumscribed pain in the flanks, haematuria and albuminuria, large kidney shadow radiologically, loss of renal function. Reported cases and the three personal ones suggest a trial of thrombectomy. It is not known how long the kidneys can tolerate venous occlusion. But the personal observations suggest that even occlusion lasting for serveral days may be reversible. In one patient with renal-vein thrombosis after unrecognised misplacement of a Mobin-Uddin filter into the right renal vein, surgical restoration of venous drainage after several weeks indicates that long-term observations are necessary to judge final results.

Acute Disease↗
PubMed1978

[Reappraisement of lymphangiography in Hodgkin's disease. Comparison with 109 primary staging laparatomies (author's transl)].

Accuracy of lymphangiography was estimated in 109 patients with Hodgkin's disease by comparing its results with those of primary staging laparotomy. Accurate lymphangiographic diagnosis was achieved in 90% of involved and 85% of non-involved para-aortic lymph nodes, respectively. 11 of 12 false-positive cases were due to over-interpretation of lymph nodes exhibiting no enlargement but showing filling defects. Involvement without enlargement of lymph nodes appears to be a rare, even in young patients. Although staging laparotomy is of advantage, particularly when other methods fail to give reliable results, lymphangiography is still a valuable method for staging of Hodgkin's disease.

Diagnostic Errors↗
PubMed1977

[Primary and secondary exploratory laparotomy and splenectomy in Hodgkin's disease (author's transl)].

Exploratory laparotomy with splenectomy was performed on 275 patients with hisologically confirmed Hodgkin's disease. In 188 patients the laparotomy was a primary one to determine more precisely the state of the disease. A secondary laparotomy was performed in 87 patients 1-12 years after diagnosis and radiotherapy. In 17.5% of patients the state had to be revised after laparotomy with splenectomy. In 38 the disease had further progressed, while in ten it had slighty regressed. In four cases clinical stage I proved to be stage III. Even prognostically more favourable forms may have progressed at first diagnosis. There was no correlation between B-symptoms and histological type, but there was between B-symptoms and spread of the disease. Calculated spleen weight provided no clue as to spleen involvement. There was no clear relationship between spleen involvement and histological subclassification. Risk-effect analysis indicate that laparotomy with splenectomy was useful because it makes optimal treatment possible.

Adult↗
PubMed1977

[Disorders of the cerebral function in patients in a dialysis-transplantation program].

36 patients of a dialysis-transplantation program with well functioning cadaver kidneys were investigated psychometrically for organic losses in intellectual function. 50% of the patients showed organicity an average of 16 months after transplantation. These organic deficits were found significantly more often when dialysis treatment had been complicated by marked medical problems. It is concluded that early transplantation of well dialyzed, medically fit patients will contribute to preventing persistent organic brain syndromes.

Adolescent↗
PubMed1977

[Renal transplantation: results and conditions for donor-nephrectomy (author's transl)].

The role of renal transplantation as a method of treatment of chronically uraemic patients is presented considering recent data. The number of chronically haemodialysed patients is 64,0000 in the world. About 20,000 kidneys have been transplanted. In spite of advantages of a combined treatment by dialysis and transplantation, the frequency of transplantation is very low in West Germany. Lack of donor-organs is one of the most striking factors in this situation. Cooperation between the different disciplines would solve these problems. The conditions for donor procurement are presented.

Brain Death↗
PubMed1976

[Spontaneous rupture of the oesophagus (author's transl)].

During the last 4 years three so-called spontaneous perforations of the oesophagus were treated, twice by surgical intervention 12 anys after the rupture. Two patients survived. The classical history of retching or vomiting and retrosternal splitting pain is indicative, wht medium, amidotrizoate sodium (Gastrografin), from the oesophagus. Prognosis depends decisively on the time of operation after the rupture. Direct suture of the rupture with plastic coverage of the defect by sewing on of the gastric fundus or by plication of the fundus have proved valuable.

Esophageal Diseases↗