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Biomedical subjects

F Bellini

Publications and source records attributed to F Bellini.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Malignant melanoma of the small intestine].

Three patients with intestinal metastases from a malignant melanoma are presented. The pathological and clinical findings are reviewed. The symptoms are variable , but usually include unexplained anemia, gastrointestinal bleeding, abdominal pain and intestinal obstruction. X-ray examination of gastrointestinal tract can reveal multiple metastatic lesions with so-called typical "Bull's eye" sign. Surgical excision is indicated and extended survival due to improved chemotherapy and immunotherapy is stressed.

Aged↗
PubMed1984

Total intravenous hyperalimentation (TIH) complications in childhood: a radiological survey.

Sixty consecutive patients, except for one 7-year-old patient, their ages varying from 1 day to 12 months received total intravenous hyperalimentation (TIH). It was possible to observe non-pathological catheter malpositions and, in 14 patients, other complications. The most serious complications observed included the following: thrombus and pericatheter thrombus calcification; superior vena cava thrombotic occlusion; hydrothorax; mediastinal effusion; generalized septic arthritis; venous transfixion with flooding of the soft tissues of the neck; vein wall lesions; collateral vertebral circulation; and a catheter tip blocked in vein. A brief comment is given on the use of this procedure and what may happen.

Arthritis, Infectious↗
PubMed1984

Wedge-shaped epiphyses of the knees in two siblings: a new recessive rare dysplasia?

A peculiar form of metaphyseal dysplasia, mainly of the lower limbs, occurred in two male siblings born to healthy, unrelated parents. The clinical and radiological features were short stature, psychomotor retardation, accelerated bone maturation, the limbs and especially the knees showing cup-shaped widening of the ends of the metaphyses and wedge-shaped widening of the epiphyses. This condition does not fit the description of any syndrome reported so far and may therefore be classified as a new recessive dysplasia.

Bone Diseases, Developmental↗
PubMed1983

[Behavior of serum immunoglobulins in boutonneuse fever].

The behaviour of serum immunoglobulins in 35 patients suffering from Mediterranean exanthematous has been studied. No particular quantitative or qualitative change lieve noted. Supported by the scanty and contrasting data in existing literature, it is maintained that aspecific immunological serum doses are of little use, but research is urged into specific antibodies by means of indirect immunofluorescence and the Elisa method.

Adult↗
PubMed1981

[Laparosplenectomy in Hodgkin's disease].

Assessment of a series of 102 cases of laparotomy with splenectomy in the diagnosis of Hodgkin's disease is undertaken in an explantation of the indications for its employment in relation to the progress of the disease and its histological type. An account is also offered of the salient features of each surgical stage, and the findings made during surgery by comparison with those obtained in other ways, i.e. preoperative appraisal based mainly on lymphography, hepatosplenic scintiscans, and functional exploration of the liver. Analysis of the results in the light of the histological data and their clinical and pathological relations enables four conclusions to be drawn: 1) isotopic investigations and functional tests carried out prior to surgery are insufficient, or at any rate poorly reliable; 2) absence of gross criteria for the sufficiently precise determination of splenic Hodgkin sites intraoperatively; 3) discrepancy between the lymph node histology and the lymphographic picture; 4) high incidence of primary subdiaphragmatic splenic involvement. The opinion is expressed that laparosplenectomy is a sound procedure for establishing the actual extent of Hodgkin's disease, and hence permitting more logical and more accurate further management. Emphasis is also laid on the fact that removal of the spleen may protect the liver from the possible spread of the disease via the porta, and make irradiation of the left hypochondriac region with its attendant dangers unnecessary.

Adult↗
PubMed1981

Bone changes in end-stage oxalosis.

Primary hyperoxaluria is a rare metabolic disease characterized by exaggerated production of oxalic acid. Clinically the disease is characterized by recurrent calcium nephrolithiasis, progressive renal failure, and early death in uremia. As the regular dialysis treatment may prolong survival, a new syndrome may develop. This is due to intense and continuous deposition of calcium oxalate crystals in soft and bone tissues. The radiologic aspects of oxalate deposition in four adult patients on chronic renal dialysis with histologic and clinical evidence of massive bone oxalosis are reported.

Adolescent↗
PubMed1980

Influence of lecithin:cholesterol acyltransferase on cholesterol metabolism in hepatoma cells and hepatocytes.

Cholesterol content and synthesis were measured in rabbit hepatocytes and rat hepatoma cells (Fu5AH) incubated in rabbit serum at concentrations ranging from 2.5% to 50%. Values were compared to controls grown in delipidized serum protein. Cellular cholesterol content varied inversely with the serum concentration, whereas cholesterol synthesis was elevated as serum concentration in the incubation medium was raised. The reduction in cellular cholesterol content and the elevation in synthesis observed with the cells incubated in high concentrations of fresh serum could be correlated with the extent of serum lipoprotein modification by lecithin:cholesterol acyltransferase. Unmodified serum in which LCAT had been inactivated depressed cholesterol synthesis and increased cellular cholesterol content at all concentrations. The presence of active LCAT was not required for the cellular responses, since serum which had been modified before LCAT inactivation also stimulated cholesterol synthesis and decreased content. Qualitatively similar results were obtained with human, rat and rabbit sera. Fractionation of serum demonstrated that the stimulatory activity of LCAT-modified serum was associated primarily with the high-density lipoprotein fraction. Comparative cholesterol flux studies using prelabeled hepatoma cells exposed to either normal or modified high-density lipoproteins demonstrated that cellular cholesterol efflux was somewhat depressed in the presence of the modified lipoprotein whereas cholesterol influx was markedly reduced. These data indicate that LCAT modification of serum lipoproteins alters the relative rates of cholesterol flux with the major effect being on cholesterol uptake. This results in a net loss of cholesterol from the cells accompanied by a stimulation of cholesterol synthesis.

Acetates↗
PubMed1977

Prognostic significance of radiological bone involvement in childhood acute lymphoblastic leukaemia.

In 98 children with acute lymphoblastic leukaemia, aged 1 to 12 years, the prognostic significance of radiological bone involvement was studied. The mean duration of remission and of survival was much shorter in cases with multiple bone involvement (3 or more bones) than in those where bone involvement was absent. In those cases presenting with 1 or 2 bone lesions no statement of prognostic significance can be made at this stage. A radiological skeletal survey should be made in all children presenting with leukaemia to identify those (about 15%) having multiple bone lesions and therefore a poor prognosis, in order that they can be given more intensive therapy.

Bone Neoplasms↗
PubMed1976

The radiological diagnosis of the fetal-face (= Robinow) syndrome (mesomelic dwarfism and small genitalia). Report of 3 cases.

Report of 3 cases with Robinow syndrome. Analysis of the X-ray findings, including the formerly reported cases. On radiological grounds, the diagnosis of the Robinow syndrome is possible by the combined observation of mesomelic shortening of the extremities, hemivertebra formation and fusion anomalies of spine and of the ribs. The "splitting" of terminal (bifid) phalanges and toes is a facultative, but highly diagnostic radiological sign. In 2 cases, the pattern profiles were of considerable similarity. The practical importance of the correct diagnosis in this syndrome is emphasized.

Adolescent↗
PubMed1975

Lecithin:cholesterol acyltransferase activity in hypercholesterolemic subjects and in hypercholesterolemic subjects treated with clofibrate.

The lecithin:cholesterol acyl transfer reaction in the plasma of hypercholesterolemic subjects and of hypercholesterolemic subjects treated with clofibrate was studied. An increased enzyme activity was found in the first group of patients, while lecithin:cholesterol acyl transfer activity tended to normalize in the second group. This increased enzyme activity might be a defense mechanism against the accumulation of cholesterol in the arterial wall.

Acyltransferases↗
PubMed1975

Relationship between fatty acids of adipose tissue and plasma cholesterol.

The fatty acid composition of adipose tissue from normal and hypercholesterolemic men and women was studied. We found a difference in the fatty acid composition between both sexes. A decrease in linoleic acid was found in hypercholesterolemic men, while there was an increase in palmitic and totally saturated acids in women. A decrease in total monounsaturated and in monounsaturated/saturated ratio was also found in women.

Adipose Tissue↗