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Biomedical subjects

F Ben Moussa

Publications and source records attributed to F Ben Moussa.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Infantile forms of primary hyperoxaluria type I: apropos of 4 cases].

BACKGROUND: Approximately 10% of the cases with primary hyperoxaluria type I present before age 1 and are usually classified as neonatal primary oxaluria. CASE REPORTS: Four unrelated infants, aged 3 to 9 months, were admitted for severe renal failure due to primary hyperoxaluria type I. Other affected members were known in two of these four families but the disease was not present at the same age in each family. Echogenicity of kidneys was increased in all the patients and calcium oxalate crystals were seen in the collecting system and within the renal parenchyma. Urolithiasis was not present. Treatment of renal failure, ie, peritoneal dialysis, was uneffective in one patient and was interrupted in two others because organ transplantation was impossible. CONCLUSIONS: The infantile forms of primary hyperoxaluria type I may be rapidly complicated by severe renal failure in the absence of urolithiasis.

Female↗
PubMed1995

[Adult uveitis: apropos of 1 case with acute idiopathic interstitial nephritis].

The association of acute interstitial nephritis and uveitis is rare. In 1975, Dobrin reported a new syndrome in two children presenting acute interstitial nephritis, anterior uveitis and marrow-lymph node granulomas. We report one case of this association in the adult. A 35-year-old man was admitted to the hospital for acute renal failure, arthralgia and anterior uveitis. The infectious and the immunological investigations were negative. The ocular examination shows bilateral anterior uveitis. The renal biopsy revealed acute tubulo-interstitial nephritis. He was treated by prednisone (0.5 mg/Kg/day). His clinical course was favorable. Seven years later, the renal function is normal and we not observed a relapse of his uveitis.

Acute Disease↗
PubMed1993

Hypertension in primary chronic glomerulonephritis analysis of 359 cases.

The incidence of hypertension was evaluated in 359 patients with primary chronic glomerulonephritis who underwent renal biopsy. It was compared to a control group of 7,468 subjects who were obtained from an epidemiologic study performed in the same area at the same period. The prevalence of hypertension was 42%. On the basis of multiple regression analysis, the level of blood pressure was shown to be positively correlated to four independent variables: age, body mass index, degree of renal insufficiency and presence of proliferative glomerulonephritis. It was concluded that, although renal insufficiency increases the incidence of hypertension, proliferative lesions play an important contributive role in the development of hypertension.

Adolescent↗
PubMed1993

Ten-year results utilizing chemotherapy as primary treatment in nonmetastatic, rapidly progressing breast cancer.

Eighty-three patients with rapidly progressing breast cancer (RPBC) were entered into a study of primary chemotherapy (cyclophosphamide, methotrexate, and 5-fluorouracil) and subsequent randomization to surgery or radiotherapy for control of local/regional disease. Eighty-three of these patients with redness, warmth, and edema compatible with clinical "inflammatory breast cancer" served as the focus for our analysis of factors associated with improved survival. The stage-specific disease-free intervals (DFI) of 36 and 21 months were substantially longer than in the earlier series (26 and 16 months) from the same institution. The evaluation of individual prognostic indicators revealed that the initial tumor size and the initial response to chemotherapy were the two independent factors most important in predicting the DFI. The continuing unmaintained 1-year remission in at least 12 patients supports the rationale for aggressive therapy in RPBC or "inflammatory breast cancer."

Adult↗
PubMed1990

[Membranoproliferative glomerulonephritis in 2 brothers].

In one sibship, two brothers had membrano-proliferative glomerulonephritis type I. The former died 3 years after the onset of the glomerulonephritis and the latter is still alive. The familial nature of the disease is an argument to strengthen the concept that genetic factors are involved in its origin.

Adolescent↗
PubMed1986

[Treatment of chronic renal failure in Tunisia].

Treatment of end-stage renal disease started in Tunisia in 1968 and has been used for 543 patients; 364 of them are still living. There are now 10 centers, 4 in public hospitals and 6 in private centers. Transplantation is still performed abroad. Among living patients, 312 (86%) are on hemodialysis, 11 (3%) are on CAPD and 41 (11.2%) are living with a transplanted kidney. The mean survival rate of patients is similar to the European mean and professional rehabilitation is good in most cases. New dialysis centers are planned to open and renal transplantation with related living donors will probably be performed soon.

Adult↗
PubMedDate not supplied

Impact of initial blood pressure on the mortality of diabetics undergoing renal replacement therapy.

The aim of this study was to determine the blood pressure (BP) profiles and their impact on mortality among a cohort of uremic diabetics treated by hemodialysis. The studied population includes all type II diabetics starting hemodialysis for end-stage renal disease between 1990 and 1996. There were 221 patients (144 men, 77 women) aged from 37 to 78 years, were all followed until death or December 2003 without any censored data. Survival analysis to identify predictors of death was performed using the actuarial method, Cox proportional model, including systolic, diastolic, mean, and pulse blood pressures (SBP, DBP, MBP, PP). One hundred seventy-eight patients (80.5%) were hypertensive at the start of dialysis. Hypertension preceded the diagnosis of diabetes in eight cases (4.5%); 154 patients (86.5%) received antihypertensive drugs and only 23 (14.9%) had well-controlled hypertension. Our population was subdivided into four groups according to their BP levels at the time of beginning of dialysis; G1 (19.5%): normal BP (SBP [90 to 140] and DBP [60 to 90]); G2 (30.3%): Hypertension stage 1 (SBP [140 to 160] and/or DBP [90 to 100]); G3 (32.1%): hypertension stage 2 (SBP [160 to 180] and/or DBP [100 to 110]); G4 (18.1%) hypertension stage 3 (SBP [180 to 220] and/or DBP [110 to 120]). Mean age and comorbidities were similar among the four groups. During a cumulative follow-up period of 872 patient-years, 191 patients died, representing a rate of 21.9 per 100 patient-years; 20.42% of these deaths occurred during the first 3 months of dialysis. Normotensive patients showed lower survival rates without any significant difference in comparison with those of other hypertensive groups. None of the initial BP parameters (SBP, DBP, PP, MBP, hypertension stages) seemed to influence early or global mortalities, which were rather related to the urgent onset of renal replacement therapy, to age, to serum albumin, and to the score of associated morbidities. We conclude that mortality of our hemodialyzed diabetics was not influenced by the blood pressure parameters recorded at the onset of dialysis.

Adult↗