Biomedical subjects

F Benthein

Publications and source records attributed to F Benthein.

4 recordsLinked to original sources

PubMed1990

[Malaria morbidity in Comoros].

After a short epidemiological description on the malaria situation in the Grande Comoro Island, the authors fix the threshold of the pyrogenic parasite density. The studies carried out in out-patients and a pediatric in patients department allowed the authors to assess the place of malaria in the pathology. Second motive for seeking medical advice for fever in children, malaria is the first cause of dead in hospitalized children between 1 and 4 years. The morbidity and mortality decreases rapidly from the age of five and the limit seems to be reached at the age of 10. Perennial transmission does not result in seasonal variation of the morbidity although the prevalence, in active detection, of malaria infection is significantly higher in the raining season than in the dry season.

Antimalarials↗

PubMed1989

[A survey of filariasis in the Comoro Islands, in Great Comoro and Mohéli].

The filariasis of W. bancrofti with nocturnal periodicity is, together with malaria, the principal endemic disease in the Comoros Islands. Well studied on Mayotte island, which remained a French Territorial Collectivity, its prevalence and distribution are less known in the Grand Comoros, Anjouan and Moheli islands which form the Federal Islamic Republic of the Comoros. The study of the nocturnal microfilariae in the Grand Comoros and Moheli in 1987 is the opportunity to assess the situation of the disease on this archipelago.

Adolescent↗

PubMed1989

[In vivo chemosensitivity of Plasmodium falciparum in the Islamic Federal Republic of the Comoros].

The RFI des Comores is classified by WHO as an area where P. falciparum resistance to chloroquine is rare or low. After reviewing the existing data, the authors are giving the results of an in vivo research in 1988-1989. 1.35 of the tests with 25 mg/kg were positive the 7th day, 3.38% of 207 tests with 20 mg/kg, 10.77% of 232 tests with 10 mg/kg, 21.56% of 51 tests on 5 mg/kg.

Adolescent↗

PubMed1986

[Drug resistance of Plasmodium falciparum in Congo. I. In vivo study with 10 and 25 mg/kg of chloroquine (235 tests)].

An evaluation of chloroquine resistance in P. falciparum was conducted in four different areas of the People's Republic of the Congo during the months of October and November 1985. Using the simplified seven day in vivo test protocol, 235 tests were completed in 92 children aged three months to five years seen at the Maternal Child Health Clinics (54 children were treated by a single dose at 10 mg/kg and 38 children were treated by the three day dose of 25 mg/kg) and 143 school children aged six to 12 years (70 treated by 10 mg/kg and 73 treated by 25 mg/kg). In three of the zones (Brazzaville, the forest mountains of the Mayombe and Chaillu), a high level of resistance was found in the percentage of children with asexual forms of P. falciparum parasites (1 000 leucocytes) in the blood smears. After 7 days, the percentage of positive results in children treated by 10 mg/kg was found to be 65.5% and 29.3% for children treated by 25 mg/kg. Failure rates, independent of parasite density, were less in school aged children. A significant number of observations seems to be Type II resistance. The situation is more favorable in the fourth area of Likouala, a region of flooded forests in the north of the country.

Child↗