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Biomedical subjects

F Bertomeu

Publications and source records attributed to F Bertomeu.

12 recordsLinked to original sources
PubMed1995

[Noninvasive ventilator support in patients with chronic obstructive pulmonary disease. A comparison of 2 methods].

The external high frequency oscillation around a negative baseline (EHFO-NB) is a new mode of non-invasive ventilatory support which could replace or complement nasal intermittent positive pressure ventilation (NIPPV) for treatment of patients with chronic obstructive pulmonary disease, both in the decompensation phases and as preventive measure in intercrisis periods. This was a prospective study in which tolerance and short term effects on acid-base balance and gas interchange of both NIPPV and EHFO-NB in twenty patients with severe chronic obstructive pulmonary disease were compared. With both methods similar decrease in PaCO2 and increases in pH were observed, with decrease and increase in respiratory frequency when using NIPPV and EHFO-NB, respectively; the latter in association with the high oscillation frequencies used. While an improvement of SaO2 and no changes in PaO2 and intrapulmonary shunt were observed on NIPPV, a decrease was observed in the SaO2 and an increase in the shunt on EHFO-NB. Comfort of patients, improvement of perceived sensation of dyspnea, and the absence of complications were similar with both methods. While on NIPPV, 75 per cent of patients required a short period of training and continuous supervision.

Aged↗
PubMed1980

[Value of the measurement of gases in the diagnosis of pleural effusion (author's transl)].

Determination of pH and measurement of pCO2 and pO2 have been systematically included in the study of 183 patients with pleural effusion. According to selective etiologic criteria the effusions were divided into four categories: those of cardiac origin (42), non-specific infectious (14), tuberculous (22) and neoplastic (20). A pH inferior to 6.30 seemed to be characteristic of non-tuberculous pleural effusion, and in these circumstances an associated pCO2 greater than 135 mm Hg and pO2 less than 21 mm Hg were noticed. Results in tuberculous and neoplastic cases were similar, pO2 being the only differential datum (pO2 less than 49 mm Hg and pO2 greater than 52 mm Hg, respectively). Overall results are compared to those obtained in the subgroup of pleural effusions of cardiac origin. Determination of pH, pO2 and pCO2 in pleural effusions may help to identified the etiology of this condition, specially when associated to analysis of other parameters of the aspirated fluid.

Carbon Dioxide↗
PubMedDate not supplied

Non-pigmenting cutaneous-mucosal fixed drug eruption due to piroxicam.

BACKGROUND: Piroxicam is a widely used anti-inflammatory drug. Most adverse reactions affect gastrointestinal system, liver and skin. Fixed drug eruption although very unusual, has also been described, but with cutaneous involvement exclusively. We present the case of a 49-year-old man who suffered three episodes of fixed drug eruption with cutaneous-mucosal involvement, even simulating an autoimmune disease, whenever he was treated with oral piroxicam. METHODS AND RESULTS: He was patch tested on normal skin with the GEIDC standard series and an NSAIDs series. He was patch tested on normal skin and on fixed eruption with piroxicam, meloxicam and tenoxicam (all of them 1 % pet). Oral challenge test was not performed due to the severity and reproducibility in previous reactions. Results showed a positive patch test to piroxicam (1 % pet) on fixed eruption, with negative results to the rest. CONCLUSIONS: Adverse drug reactions may present a wide variability of clinical symptoms. In these situations an accurate clinical history is necessary. To our knowledge this is the 1st report of non-pigmenting fixed drug eruption with cutaneous-mucosal involvement due to piroxicam. Cross-reactivity between oxicams could not be demonstrated by patch test on fixed eruption.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

An unusual adverse drug reaction?

INTRODUCTION: Adult Still Disease (ASD) is a rare (incidence 1-1,6/1,000,000 in Europe) seronegative polyarthropathy diagnosed with clinical criteria, excluding other etiologies. Minocycline, a semisynthetic derivative of tetracycline, has been associated with many adverse effects. We present the case of a 18-years-old man with a high suspicion of an adverse drug reaction (ADR), that was finally diagnosed of ASD. MATERIAL AND METHODS: In order to exclude other diseases, laboratory test, radiology and allergological studies were performed. The results of the allergological studies excluded the possibility of an ADR. The rest of the results determined the diagnosis of ASD. CONCLUSION: It's necessary to emphasize the importance of an accurate differential diagnosis in cases like this, because many diseases may mimic an ADR, and may be underdiagnosed (or misdiagnosed).

Adolescent↗