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Biomedical subjects

F Binoux

Publications and source records attributed to F Binoux.

7 recordsLinked to original sources
PubMed1981

[Obsessional-type compulsive behavior caused by bilateral circumscribed pallidostriatal necrosis. Encephalopathy caused by a wasp sting].

A previously healthy young man developed encephalopathy after a wasp sting in 1968. Neurological complications included chorea, currently of a minor degree, replaced by buccofacial dyskinesias and compulsive movements. The most disabling consequences were of psychic nature, the patient presenting an unusually marked compulsive activity of an obsessional type. The whole psychic picture however was quite different from that of the usual neurosis, since there was neither anxiety nor doubt, but a mental vacuum contrasting with almost normal intellectual and affective capacities. It was as though there was a loss of the auto-activation system of psychic life, postulated by dynamic psychologists. C.A.T. demonstrated bilateral pallidostriatal necrosis. This suggests that the striatum plays a motor and psychic role. In the field of motor control, its hypoactivity appears to determine not only chorea but dyskinesias similar to tics and compulsive movements. In the psychic field, the striatum appears to play the very general role of an auto-activation system of intellectual and affective life, its deficiency leading to mental activity of a compulsive nature. Improvement in knowledge of striatal biology should clarify not only the basic mechanisms of chorea, but those of tics and obsessions.

Brain Diseases↗
PubMed1980

[Retardation in depressive states : elaboration of a quantitative rating scale (author's transl)].

Important progress has been made in the knowledge of depressive states but there remains great confusion in clinical classification. It seemed interesting to investigate more precisely the semeiology of retardation which had been less studied than Depressed Mood, as it appears to be independent from aetiological factors; retardation could in fact correspond to a common behavioral pattern of all depressive states and the target of antidepressant drugs. A scale for the quantitative rating of retardation was elaborated and was tested in its first two forms which respectively 35 and 38 depressed patients. The principal component analysis of the results seems to indicate that the concept of retardation corresponds to a univocal factor accounting for almost 50% of variance, although it rests on a wide variety of motor, verbal and intellectual items. Is is now sought to study the correlation of this behavioral pattern with the efficacy of antidepressant drugs.

Depression↗