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Biomedical subjects

F Birinyi

Publications and source records attributed to F Birinyi.

7 recordsLinked to original sources
PubMed1986

The comparative effects of epinephrine versus phenylephrine on regional cerebral blood flow during cardiopulmonary resuscitation.

Epinephrine in larger doses than currently recommended during cardiopulmonary resuscitation (CPR) has been shown to improve cerebral blood flow (CBF) following a 10-min arrest in a swine model. The purpose of this pilot study was to measure CBF during CPR, comparing high-dose epinephrine to a pure alpha-1 agonist, phenylephrine. Ten swine each weighing greater than 15 kg, were instrumented for regional CBF measurements using tracer microspheres. CBF was measured during normal sinus rhythm (NSR). Following 10 min of ventricular fibrillation, CPR was begun and regional CBF was again measured. Following 3 min of CPR, the swine were randomized to receive either epinephrine (0.2 mg/kg), or phenylephrine (0.1 mg/kg), through a peripheral intravenous line. Regional CBF was again measured 1 min after drug administration. Regional CBF following drug administration was compared using an analysis of covariance. Adjusted CBFs are expressed in ml/min per 100 g for epinephrine and phenylephrine, respectively: left cerebral cortex (12.5 vs. 2.3, P = 0.002); right cerebral cortex (13.0 vs. 2.8, P = 0.003); cerebellum (32.9 vs. 4.1, P = 0.004); midbrain (35.7 vs. 2.6, P = 0.0004), pons (30.3 vs. 2.9, P = O.006); medulla (49.5 vs. 13.6, P = 0.02) and cervical spinal cord (49.6 vs. 14.1, P = 0.003).

Animals↗
PubMed1978

Distinctive protein profiles obtained from extracts of normal and atherosclerotic human aorta.

Specific areas of fourteen autopsied abdominal aortas were layer-dissected, histologically graded and solubilzed with SDS, dilute saline or SDS-urea and beta-mercaptoethanol. Comparisons were made between intima, media, lesions of progressive severity and an in-vivo thrombus. Apparent molecular weights were calculated from the Coomassie blue stained gels of these extracts extracts and each band's contribution estimated by integrative densitometry. Four minor high moleucular weight bands and six medium to low molecular weight bands were detected in the arterial extracts. Band intensity stain patterns of normal intima are easily distinguished from normal media. Extracts of minor lesions resemble normal media; higher grade lesions demonstrate increased amounts of characteristic initmal bands. The major medial band is also seen on gels of thrombus extracts. Both of the bands most characteristic of atherosclerotic lesions stain for carbohydrate. Isolation and characterization of these (glyco)proteins will provide material for binding studies. Quantitation of characteristic lesion proteins may provide insights into the proliferative phase of this disease.

Adult↗
PubMed1977

Effects of alpha-adrenergic blockade on coronary blood flow of dogs in hemorrhagic shock.

The present study was designed to test the hypothesis that the vasoconstrictive effects of alpha-adrenergic receptors are responsible, at least in part, for the lack of a maximal vasodilatation of coronary arteries during hemorrhagic shock. Open-chested, anesthetized, mongrel dogs were bled so as to reach an arterial pressure level of 44 mm Hg, and were monitored using an electromagnetic, non-cannulating flowmeter. During shock, two intracoronary injections were made, one of saline, the other of phenoxybenzamine (Dibenzyline). Control dogs had 2 injections of saline. Following phenoxybenzamine, coronary blood flow increased by 32%. These results indicate that although coronary blood flow may be mainly under local control, the sympathetic nervous system limits maximal coronary vasodilatation during hemorrhagic shock by virtue of activated alpha-adrenergic receptors.

Animals↗