[Hyperhomocysteinemia: a new marker of vascular risk: affected vascular areas, its role in the pathogenesis of arteriosclerosis and thrombosis and treatment].
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Adult↗
Biomedical subjects
F Blanco Vaca
Publications and source records attributed to F Blanco Vaca.
[Tangier disease: study of the first case in Spain].
The clinical, biochemical and pathological studies of the first case of Tangier's disease that, to our knowledge, has been detected in Spain are reported. The patient had all the characteristic features of the disease: hypercholesterolemia with very pronounced reduction of plasmatic high density lipoproteins, splenomegaly, orange yellow tonsils and peripheral neuropathy. In addition, he had pneumonia and pancytopenia. Neurological examination and computed tomography suggested cerebral involvement, not previously reported in this condition. Biopsies demonstrated lipid accumulation in the reticuloendothelial cells of diverse localizations and in Schwann's cells.
Humans↗
[Molecular biology of familial hypercholesterolemia].
The causes and mechanisms of production of familial hypercholesterolemia at molecular level is reviewed. This is a monogenic hereditary disease that frequently affects the human being it is one of the supports in the existing relationship between hypercholesterolemia and acute heart infarction. Important advances in the diagnosis and treatment of this disease have been achieved with the profound knowledge of the biochemical alteration.
Cells↗
[Analysis of adenosine deaminase and its subfractions as a diagnostic parameter in tuberculous pleural effusion].
In this paper we present the results of a study about the diagnostic utility of Adenosine Deaminase (ADA) determination for diagnosing the tuberculous pleural effusion. We carried out this study in 71 patients who came to our Hospital and were diagnosed for pleural effusion. The ADA determination was made in sera and pleural effusion of all these patients. Also we determined how much of this ADA activity was linked to microsomes or not (soluble ADA), by ultracentrifugation as a separative method. Taking as a base the data obtained and using 43 U/l as cutoff point, the Diagnostic Sensitivity of ADA determined in pleural liquid calculated was 1. This means that all patients with tuberculous pleural effusions had ADA activities higher than 43 U/l in their pleural liquid. On the other hand, Diagnostic Specificity was of 0.83. This was due to the existence of 10 false positives: 2 malignancies, 3 empyemas, 1 postpneumonia, 1 secondary to thromboembolic pulmonary disease, 1 secondary to rheumatoid arthritis and 2 of unknown origin. Results obtained show the utility, with some limitations, of ADA determination in pleural liquid in order to diagnose tuberculous pleural effusions. Neither ADA determination in sera nor quantity of ADA linked to microsomes or solubles ADA in pleural liquid seem to have great clinical interest.
Adenosine Deaminase↗
[Adenosine deaminase: biochemical characteristics and clinical significance of an enzyme key to cellular immunity].
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Adenosine Deaminase↗
[Plasma urea and creatinine as diagnostic parameters of glomerular insufficiency. Reevaluation of its significance and the degree of correspondence between both parameters in different physiopathologic situations].
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Creatinine↗
[Lipoprotein metabolism].
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Chylomicrons↗