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Biomedical subjects

F Bogetto

Publications and source records attributed to F Bogetto.

At least 37 records · Page 2Linked to original sources
PubMed1995

Type I and type II schizophrenia: relations between tonic electrodermal activity and clinical ratings before and after haloperidol treatment.

To test the hypothesis that schizophrenic patients with positive vs. negative symptoms show different tonic electrodermal patterns, 26 patients with Type I schizophrenia and 19 patients with Type II schizophrenia were evaluated before and after 2 weeks of haloperidol treatment (standard daily dose = 4.5 mg). Clinical assessments were made with the Brief Psychiatric Rating Scale, the Scale for the Assessment of Positive Symptoms, and the Scale for the Assessment of Negative Symptoms. Skin conductance level (SCL) and spontaneous fluctuations (SF) frequency were recorded for each patient. Before treatment, Type I patients showed higher SCL and SF compared with Type II patients; after treatment, a significative decrease of clinical and psychophysiological variables was found only in Type I patients.

Adolescent↗
PubMed1995

Predictors of drug treatment response in obsessive-compulsive disorder.

BACKGROUND: Although a large body of evidence indicates the efficacy of pharmacotherapy in the treatment of obsessive-compulsive disorder (OCD), a considerable percentage of these patients do not respond. Very few studies focus on factors related to treatment response of OCD. The purpose of this study was to investigate which clinical factors are related to drug treatment response in OCD. METHOD: We examined 53 OCD patients treated with either clomipramine or fluoxetine for a period of 6 months, dividing the sample into "responders" and "nonresponders" to treatment. At admission, patients were evaluated using a semistructured clinical interview, the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the Hamilton Rating Scale for Depression, and the Hamilton Rating Scale for Anxiety. We then compared acute-phase patient characteristics and response to drug treatment. Response was defined as a decrease of at least 40% in the Y-BOCS total score and a rating of "improved" or "very improved" on the Clinical Global Impressions scale within 16 weeks of treatment and maintained over three consecutive evaluations. RESULTS: By the sixth month of treatment, 31 patients (58.5%) responded to either clomipramine or fluoxetine. Nonresponders had lower age at onset and longer duration of the disorder; in addition, they showed higher frequency of compulsions, washing rituals, chronic course, concomitant schizotypal personality disorder, and previous hospitalizations. A worse response to drug treatment was predicted in a stepwise multiple regression by (1) concomitant schizotypal personality disorder, (2) presence of compulsions, and (3) longer illness length. CONCLUSION: Our findings suggest that there are distinct types of OCD with respect to drug treatment response. They provide indirect evidence of treatment specificity by identifying characteristics responsive to different modalities, which may be of value in the selection of patients for alternative treatments.

Adolescent↗
PubMed1994

[The general practitioner and psychiatric assistance. A study carried out in the Piedmont region].

The study examines the relation between the general practitioner, in the Piedmont Region, and the possibility of providing psychiatric assistance (direct prescription of psychopharmacological treatment, psychological interview for generally psychotherapeutic purposes, referral of patient to psychiatric specialist) within the context of out-patient activities. For this purpose a 24-question questionnaire was drawn up and sent to 303 G.P.'s Piedmont whose names were supplied by the Italian Society of General Medicine. One hundred and forty-four GPs returned the answered questionnaire; from an analysis of the replies it emerged that the problems (GP's personal anxiety, lack of specific training, problems of time, payment and diagnosis of psychiatric disorders) concerning the relation between the said GPs and the aforesaid psychiatric assistance have not changed over the past 15 years even in view of the high attendance rate of patients with psychic pathologies and a widespread readiness of the GPs to take personal responsibility for these patients.

Drug Prescriptions↗
PubMed1993

[Generalized anxiety disorder. Clinical and nosological remarks].

The authors review current understanding of generalized anxiety disorder, with particular regard to the clinical description made by the DSM-III-R. Discussion is focused on the validity of the diagnostic criteria of the disorder and on the debate on the nosological position of the illness. The review cites evidence regarding prevalence of the disorder and data on its comorbidity with the other anxiety disorders and with mood disorders. Evidence on intra-episodic, longitudinal and familial co-morbidities are assessed. Aspects of psychopathology of generalized anxiety disorders are also discussed.

Anxiety Disorders↗
PubMed1980

[Psychoneurosis and drug abuse].

In a short communication addressed particularly to medical doctors, the Authors make a statement about the concepts of psychoneurosis and psychosomatic disease, taking into consideration the hypothesis of a psychopharmacological treatment. The Authors consider the drug as a complementary tool in the relationship between the doctor and the patient, useful in making easier the overcoming of the conflicts and as a coadjuvant in a strategy of both psychopharmacology and psychotherapy.

Humans↗
PubMed1975

The relation between cerebral serotonin levels and conditioned behaviour in the rat following the administration of LSD-25 and UML.

Successive daily injections of LSD-25 and UML (1-methyl-d-lysergic acid butanolamide) caused progressive depression of brain 5-HT levels in the rat. On the fourth day, the decrease was significant with respect to the highly significant fall observed after a single administration, whereas it had been shown earlier that conditioned behaviour is no longer affected by LSD-25 after 3 days and that simultaneous administration of a single dose of LSD-25 and UML is equally ineffective in this respect. Its depression of 5-HT levels, however, has now been shown to be equal to that of LSD-25 alone at doses that influence conditioned behaviour. The findings indicate that changes in such behaviour are not dependent on brain 5-HT levels and that no link exists between such levels and the psychotomimetic effect of LSD-25 in man.

Animals↗