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Biomedical subjects

F Borchsenius

Publications and source records attributed to F Borchsenius.

7 recordsLinked to original sources
PubMed1992

[Bacteriological examination of bronchial aspirates obtained via fiberoptic bronchoscopy].

We present the bacteriological findings in 329 aspirates from fiberoptic bronchoscopy. Quantitative cultures were not performed. 92 of the patients had radiologically confirmed pneumonia, 58 possibly had infectious bronchitis or pneumonia which was not verified radiologically, 154 had other pulmonary diseases and 25 had no verified pulmonary disease. 13% of aspirates contained no bacterial isolates and 33% revealed growth of multiple bacteria, classified as "normal pharyngeal flora". Among the 54% with specified bacterial findings the most frequent bacteria were viridans streptococci, staphylococci, Haemophilus influenzae, and Streptococcus pneumoniae. The differences in bacterial flora between the patient groups were only minimal. Klebsiella and Escherichia coli were the only bacteria indicating presence of pneumonia. S pneumoniae were found more frequently among patients with no signs of infection. Bronchial aspirates obtained with a fiberbronchoscope may give false positive results and are of limited value in diagnosing pneumonia. However, the presence of gram negative intestinal rods may indicate bacterial respiratory infection in hospitalized patients. Improving sampling and culture techniques can possibly improve the value of bacteriological findings.

Bacterial Infections↗
PubMed1991

Systemic meningococcal disease: the diagnosis on admission to hospital.

The clinical and laboratory findings in 176 patients hospitalized with suspected systemic meningococcal disease (MCd) are presented. All except nine patients were prospectively included in the MenOPP study. One hundred and fifteen patients were most likely to have meningococcal disease, of these 71 were confirmed with growth of meningococci in blood and/or cerebrospinal fluid (CSF). The remaining sixty-one patients served as the control group. Both petechiae, reduced general condition, and reduced consciousness proved valuable in the diagnosis of MCd. Petechiae was the clinical sign best discriminating between MCd and the control group. Ecchymoses were specific for meningococcal disease. Among the laboratory tests C-reactive protein (CRP) and Thrombotest (TT) were the tests which most frequently were found to be abnormal in patients with meningococcal disease. A diagnostic score is computed by the aid of a multiple regression analysis. This score includes the variables skin hemorrhages, body pain, CSF cell count, TT, CRP and white blood cell count. For a patient hospitalized with suspected MCd a score of three or more supports the diagnosis and should indicate the need for rapid antibiotic therapy.

Anti-Bacterial Agents↗
PubMed1989

[Cyclophosphamide-induced pneumonitis].

Cyclophosphamide is an alkylating agent with a wide spectrum of activity against malignant tumours. Because of its pronounced immunosuppressive effect it is also frequently used in organ transplantations and in the treatment of certain autoimmune diseases. The drug has toxic side effects, however, some of which are ascribed to specific metabolites. This report describes a patient who developed cyclophosphamide associated cystitis and pneumonitis while being treated for Wegener's granulomatosis. Early recognition of the condition and discontinuation of therapy is essential for a favourable outcome.

Adult↗