Biomedical subjects

F Bourcier

Publications and source records attributed to F Bourcier.

5 recordsLinked to original sources

PubMed2004

[Bilateral acute retinal necrosis syndrome associated with meningoencephalitis caused by herpes simplex virus 2. A case report].

INTRODUCTION: Acute retinal necrosis syndrome (ARN syndrome) is a rare viral disease with a poor prognosis in most cases. It is characterized by substantial ocular inflammation with progressive retinal necrosis, occlusive vasculitis and sometimes extraocular features. CASE REPORT: We report the case of a 62-year-old woman who was referred for a suspicion of a stroke. Ophthalmological examination revealed a profound bilateral visual loss due to extensive retinal necrosis. The patient was immediately treated with antiherpetic drugs. ARN syndrome with meningoencephalitis caused by herpes simplex virus type 2 was confirmed by PCR studies performed on aqueous humor and cerebrospinal fluid. Herpes simplex virus 2 (IgG+ , IgM-) was probably reactivated after intrathecal injection of steroids because of pain associated with narrowing of the lumbar vertebral canal. The patient was treated with intravenous Acyclovir for 3 weeks. After 4 months, both retinas were detached. DISCUSSION AND CONCLUSION: ARN syndrome caused by herpes simplex virus 2 most often occurs after reactivation of the latent virus in patients with a neurological medical history or congenital infection. Antiviral treatment must begin early to decrease risks of bilateralization and complications.

Acyclovir↗

PubMed2002

[Lisch nodules].

Explore the source record for details and available documents.

Hamartoma↗

PubMed2002

[Carbohydrate-deficient glycoprotein syndrome and progression in electrophysiological results].

PURPOSE: To document the progression of clinical and electrophysiological abnormalities in an infant with carbohydrate-deficient glycoprotein syndrome type Ia (CDGS Ia) over a period of 5 years. PATIENT AND METHODS: A 12-month-old male underwent clinical ophthalmic and electrophysiological examination at the age of 1, 2, and 6 years. Neurological examination, magnetic resonance imaging of the brain and a genetic study were also undertaken. RESULTS: Clinical examination revealed hypotonia and ataxia with a convergent squint, nystagmus, myopia with pontocerebellar hypoplasia on the MRI of the brain. The initial electroretinogram showed reduced amplitude of the scotopic and photopic b wave. At 3 years of age, biological and genetic evaluations confirmed the diagnosis of CDGS Ia. At 6 years of age, the electroretinogram was flat with a marked delay in psychomotor development. CONCLUSION: Carbohydrate-deficient glycoprotein syndrome type Ia is a recently described cause of progressive retinal degeneration and an electroretinogram should be taken in patients with psychomotor retardation of unknown etiology. In addition, strabismus associated with electrophysiological signs of anomaly should raise the possibility of CDGS Ia.

Congenital Disorders of Glycosylation↗

PubMed2002

[Activity and epidemiology in an ophthalmological emergency center].

PURPOSE: To investigate the numbers and characteristics of patients with ophthalmological emergencies presenting at a general hospital. METHODS: Retrospective analysis of ophthalmological emergencies over 11 years included comparison with demographic changes and, over the last 2 years, analysis of the patients treated (age, sex, and pathology, according to 23 preselected pathologies). Ophthalmological examinations were done by a senior ophthalmologist. RESULTS: The activity rose from 396 patients in 1989 to 2,793 in 2000. The prevalence of ophthalmological emergencies in the area was 5.1 per 1,000 residents. The ophthalmological emergency rate compared with all emergencies in a general hospital classified as an Emergency Department Hospital was 5%. The male to female ratio was 1.88, the excess being explained by the higher risk of injury in men (professional and domestic). Of these patients, 28% were under 18 years of age, 43% were between 18 and 40, and 29% were over 40 years old. Most patients were self-referred. Fifty-three percent of the patients were from the hospital's influence sector. Of all ophthalmic patients, 3%-5% were hospitalized, 65% for medical reasons and 35% for surgical and trauma reasons. We pre-listed 23 pathologies to screen our patients, which covered 95% of all the patients examined in the emergency department. These ophthalmological medical emergencies were classified as follows: 20% infections disease, 12.6% ocular inflammation, 0.8% neurophthalmology. Traumatology can be classified as follows: 6.4% ocular burns, 2% electrical arc injuries, 35.3% corneal lesion, 10% injuries of conjunctiva, sclera, corneosclera, lacrimal duct, and 1% perforation of the eyeball. CONCLUSION: There is a real need for ophthalmic emergency services in general hospitals. Benign pathologies not needing diagnosis and adapted treatment were not noted in our study. The cheapest and most efficient way to diagnose these ophthalmic emergencies appeared to be the ophthalmological emergency center with a senior ophthalmologist, according to the regional health organization.

Adult↗

PubMed1999

Primary trigeminal afferents to the vestibular nuclei in the rat: existence of a collateral projection to the vestibulo-cerebellum.

Projections from the mesencephalic trigeminal nucleus to the vestibular nuclei were analyzed using retrograde and anterograde tracing methods. The results show that neurons in the caudal part of the trigeminal mesencephalic nucleus project mainly to the medial, inferior and lateral vestibular nuclei and moderately to the peripheral part of the superior vestibular nucleus. Using the double-labeling technique we demonstrate that individual neurons of the mesencephalic nucleus send collaterals to the vestibular nuclei and the vestibulo-cerebellum. These results suggest that these anatomical connections are involved in mechanisms of eye-head coordination.

Animals↗