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Biomedical subjects

F Brahme

Publications and source records attributed to F Brahme.

At least 19 recordsLinked to original sources
PubMed1986

Magnetic resonance imaging of hemorrhagic cerebral infarction.

A comparative study between magnetic resonance (MR) and computed tomography (CT) showed MR to be more sensitive than CT for detecting subacute and chronic hemorrhage into cerebral infarction. The hemorrhage appeared as either high signal on T1 weighted images or low signal on T2 weighted images, depending on the age of the hemorrhage. Cortical hemorrhagic infarction showed a characteristic gyral pattern. Methemoglobin and hemosiderin served as markers of previous hemorrhage into cerebral infarcts.

Adolescent↗
PubMed1979

Needle biopsy under computerized tomographic control: a method for tissue diagnosis in intracranial lesions.

Thirteen patients with intracranial lesions were submitted to a twist drill needle biopsy under computerized tomographic (CT) control, with sedation and local anesthesia. (The patients' ages ranged from 12 to 81 years.) The final diagnoses were glioblastoma in 7 patients and 1 case each of anaplastic astrocytoma, low grade astrocytoma, thrombosed arteriovenous malformation, cerebral infarct, 3rd ventricular epidermoid, and degenerative disease of the brain. Definitive diagnosis was obtained in all but 2 patients with this technique. Appropriate therapy was subsequently instituted in 11 patients without further operation. Transiently increased weakness of the previously affected limbs was the only untoward effect (4 patients). Intracranial hematoma after this procedure was seen in 1 patient in this series, as detected by the postprocedure CT scan, but there was no change in the clinical course. All patients were treated with dexamethasone for 24 to 48 hours before and for several days after the procedure to avoid decompensation of intracranial dynamics because of edema. The procedure, including appropriate level CT scans of the lesion area, was performed in approximately 1 hour in all patients. (Neurosurgery, 5: 671--674, 1979).

Adolescent↗
PubMed1977

Radiological findings in Yersinia ileitis.

Bacteriological and clinical studies of patients with acute retional ileitis indicate that numerous patients with this diagnosis have a benign ileitis of short duration, caused by Yersinia enterocolitica, whereas others develop chronic Crohn's disease. Yersinia ileitis has some clinical and radiological features in common with Crohn's disease, but the two conditions are basically separate. In Yersinia ileitis, three stages are apparent: (a) the nodular stage, lasting up to three weeks; (b) the edematous stage (4th-5th week); and (c) resolution, observed during the 5th-8th week. The radiological findings in 25 patients with Yersinia ileitis and their distinction from Crohn's disease are described.

Adolescent↗
PubMed1976

Perfluoro carbon bromides as contrast media in radiography of the central nervous system. A preliminary experimental report.

A preliminary investigation of the properties of perfluorooctyl bromide in the subarachnoid space revealed this compound to have suitable attenuation capacity and advantageous physical and biologic properties for demonstration of the brain and spinal cord. No acute or chronic neurotoxicity was encountered. Microscopy demonstrated evidence of chronic inflammatory changes subsequent to long term exposure to the compound. It was concluded that the medium was superior to iodophendylate in several respects and that it may provide an alternative to water-soluble contrast media. Perfluorohexyl bromide proved unsuitable for neuroradiologic use because of formation of excessive amounts of non-absorbable gas, leading to high subarachnoid pressure and severe neurologic deficits.

Animals↗
PubMed1976

Angiography in Crohn's disease revisited.

The diagnostic value of angiography was studied in 116 patients with Crohn's disease. Angiograms showed abnormalities in over 90% of the cases. Many angiographic features were nonspecific; only the "zoning sign" and the presence of paraintestinal mesenteric neovasculature were considered diagnostic. Crohn's colitis could be distinguished from ulcerative colitis in only 30% of the cases. Angiography, as a diagnostic adjunct to barium studies, will reveal the presence of lesions and their extent. This is particularly important in suspected postoperative recurrence of Crohn's disease. Angiography is a potential differential diagnostic aid in doubtful cases of inflammatory and malignant bowel disease.

Angiography↗
PubMed1976

Colonic changes of herpes zoster.

The lesions of herpes zoster of the colon were observed in three cases. Small polygonal mucosal blebs or small ulcerations involving a short segment of the colon and appearing in a reasonable time relationship with the cutaneous manifestations either in a corresponding or noncorresponding dermatome should enable diagnosis of this unusual condition. Recognition of this entity in the presence of these skin lesions should be obvious and therefore helpful in avoiding more aggressive and invasive diagnostic procedures.

Adult↗
PubMed1976

Roentgenology of the colon in Crohn's disease. Air contrast studies of the lesions and their development.

201 patients with Crohn's disease underwent air contrast examination of the colon. The Diagnosis was histologically confirmed in each case. Most of the pathological changes of Crohn's disease of the colon are manifested as alterations of the mucosal surface. These changes are excellently demonstrated by the air contrast technique. The roentgenologic findings in colonic Crohn's disease are being discussed as well as cecal deformities and rectal changes. Some conditions that may mimic colonic Crohn's disease are summarized. Finally the advantages and disadvantages with the air contrast technique are given.

Air↗
PubMed1975

Crohn's disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden.

A prospective epidemiological study of Crohn's disease in Malmö, Sweden, was carried out during the years 1958 to 1973. The mean annual incidence rate for the disease was 4.8 per 10(5) inhabitants at risk. The recorded incidence increased from 3.5 per 10(5) inhabitants during the initial 8-year period, to 6.0 per 10(5) inhabitants during the last 8 years of the study. The maximum annual incidence rate, 8.3 per 10(5) inhabitants in 1971, is the highest hitherto on record. A prevalence rate of 75.2 per 10(5) inhabitants on December 31, 1973 was recorded. The death rate was low: 0.15 per 10(5) inhabitants per year. The alidity of the observed high incidence rates and the rising secular trends are discussed.

Adolescent↗
PubMed1975

Dynamic aspects of colonic Crohn's disease.

Changing patterns of the lesions in colonic Crohn's disease were studied in 86 patients who underwent multiple consequetive roentgen examinations. Local progression of lesions was seen in 56 out of 86 patients; rapid local advancement from mild to severe lesions was not uncommon. Temporary regression of lesions was only seen in 7%; definitive permanent healing on conservative treatment was not observed. Preoperative extension of lesions was seen in 29%, with ultimate involvement of the rectum in 7% and development of anal fistulae in 17%. Clinical implications of the findings are briefly discussed.

Acute Disease↗
PubMed1970

A comparative radiographic and pathological study of intestinal vaso-architecture in Crohn's disease and in ulcerative colitis.

Vascular changes were seen in specimens with lesions of Crohn's disease as well as in ulcerative colitis. In Crohn's disease, the vasculature in the bowel wall was rearranged secondary to thickening of the intestinal coats. An anatomical relationship was often found between the ulcers and the point where arteries break through the muscularis propria. The vasculature was markedly increased in areas with deep ulcers and transmural inflammation, but in areas with only small ulcers and mild inflammatory reaction vascular changes were barely discernible or absent. Occlusive vascular changes were uncommon and not visible in the radiographs. In active ulcerative colitis hypervascularity was more marked than in Crohn's disease, but was confined to the mucosa and adjacent parts of the submucosa. In ;burnt-out' atrophy vascularity was not increased and only minor changes in the submucosal arteries were observed. The observations did not suggest that the vascular alterations are of primary importance for the formation of lesions in either disease.

Angiography↗
PubMed1970

Spread of lesions in Crohn's disease of the colon.

Spread of lesions in Crohn's disease of the colon was closely followed in 20 cases, representing almost one quarter of a group of surgically treated patients. Such spread occurred most commonly in an aboral direction and was usually accompanied by an exacerbation of symptoms, although spread occasionally occurred during apparently quiescent periods.

Acute Disease↗